ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 30/355 134/7206 1.21542892995e-12 ko04060 Cytokine-cytokine receptor interaction 33/355 191/7206 1.58608416873e-10 ko04610 Complement and coagulation cascades 18/355 79/7206 3.31959581417e-08 ko05164 Influenza A 27/355 167/7206 3.45104080767e-08 ko04621 NOD-like receptor signaling pathway 26/355 157/7206 3.76766902352e-08 ko05321 Inflammatory bowel disease (IBD) 15/355 56/7206 4.6646026448e-08 ko05150 Staphylococcus aureus infection 12/355 36/7206 7.277741821e-08 ko04217 Necroptosis 26/355 178/7206 4.98038537675e-07 ko05140 Leishmaniasis 16/355 75/7206 5.12102617878e-07 ko05152 Tuberculosis 25/355 187/7206 4.35752460541e-06 ko05162 Measles 19/355 120/7206 5.36089400294e-06 ko04672 Intestinal immune network for IgA production 10/355 37/7206 7.83189951691e-06 ko04650 Natural killer cell mediated cytotoxicity 16/355 97/7206 1.75787067216e-05 ko05133 Pertussis 15/355 87/7206 1.86509584591e-05 ko04620 Toll-like receptor signaling pathway 16/355 100/7206 2.60549193145e-05 ko05168 Herpes simplex infection 23/355 182/7206 2.68826271174e-05 ko04660 T cell receptor signaling pathway 18/355 124/7206 3.21911515259e-05 ko05161 Hepatitis B 22/355 173/7206 3.65179570081e-05 ko04611 Platelet activation 21/355 163/7206 4.51970916226e-05 ko04659 Th17 cell differentiation 16/355 106/7206 5.44650663634e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/355 191/7206 5.82021989675e-05 ko05340 Primary immunodeficiency 8/355 30/7206 7.21890124809e-05 ko04630 Jak-STAT signaling pathway 18/355 132/7206 7.50070094685e-05 ko05323 Rheumatoid arthritis 14/355 89/7206 0.000100621430192 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/355 135/7206 0.000100959842665 ko05145 Toxoplasmosis 17/355 126/7206 0.000135448007957 ko05160 Hepatitis C 19/355 153/7206 0.00017054751359 ko04622 RIG-I-like receptor signaling pathway 11/355 62/7206 0.000187303443131 ko04658 Th1 and Th2 cell differentiation 14/355 96/7206 0.000230564704476 ko04612 Antigen processing and presentation 12/355 77/7206 0.000342907293807 ko04670 Leukocyte transendothelial migration 18/355 151/7206 0.00041953762113 ko04623 Cytosolic DNA-sensing pathway 8/355 41/7206 0.000732757210872 ko04064 NF-kappa B signaling pathway 13/355 96/7206 0.000793912354526 ko04666 Fc gamma R-mediated phagocytosis 15/355 122/7206 0.000906164187966 ko05418 Fluid shear stress and atherosclerosis 19/355 173/7206 0.00096361156717 ko04145 Phagosome 18/355 162/7206 0.00122955625398 ko05144 Malaria 8/355 45/7206 0.00139184107675 ko05131 Shigellosis 11/355 82/7206 0.00213705652189 ko05212 Pancreatic cancer 11/355 83/7206 0.00235773965314 ko00120 Primary bile acid biosynthesis 5/355 20/7206 0.00236737722874 ko04062 Chemokine signaling pathway 20/355 201/7206 0.00244429735969 ko05320 Autoimmune thyroid disease 6/355 29/7206 0.00248022925274 ko05132 Salmonella infection 12/355 98/7206 0.0029935111001 ko05034 Alcoholism 3/355 238/7206 0.00356028138923 ko04662 B cell receptor signaling pathway 11/355 88/7206 0.00375459897871 ko05330 Allograft rejection 5/355 24/7206 0.00551884545184 ko05166 HTLV-I infection 25/355 292/7206 0.00788838907416 ko04668 TNF signaling pathway 13/355 120/7206 0.00815809801056 ko05310 Asthma 4/355 17/7206 0.00826841817719 ko05332 Graft-versus-host disease 4/355 18/7206 0.0102253375774 ko04072 Phospholipase D signaling pathway 18/355 197/7206 0.010938013282 ko00592 alpha-Linolenic acid metabolism 4/355 19/7206 0.0124589699547 ko04640 Hematopoietic cell lineage 8/355 64/7206 0.0127047261735 ko05142 Chagas disease (American trypanosomiasis) 13/355 130/7206 0.0127535202406 ko04664 Fc epsilon RI signaling pathway 9/355 77/7206 0.0128999778512 ko00590 Arachidonic acid metabolism 7/355 52/7206 0.0131103120388 ko03013 RNA transport 2/355 166/7206 0.0175101391262 ko05416 Viral myocarditis 7/355 55/7206 0.0175450290716 ko01200 Carbon metabolism 1/355 128/7206 0.0214707976859 ko00281 Geraniol degradation 2/355 5/7206 0.0219186080429 ko04724 Glutamatergic synapse 2/355 152/7206 0.0349107251946 ko04728 Dopaminergic synapse 3/355 185/7206 0.0363878433368 ko04015 Rap1 signaling pathway 21/355 278/7206 0.0467867186538 ko05010 Alzheimer's disease 4/355 202/7206 0.0470737353201 ko00966 Glucosinolate biosynthesis 1/355 1/7206 0.0492645018042 ko00140 Steroid hormone biosynthesis 5/355 41/7206 0.0493532794117