ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	190/1146	423/7206	1.38106512211e-48
ko04724	Glutamatergic synapse	90/1146	152/7206	9.44508433338e-35
ko05033	Nicotine addiction	48/1146	56/7206	7.81165460285e-31
ko05032	Morphine addiction	66/1146	110/7206	3.54489411408e-26
ko04713	Circadian entrainment	74/1146	136/7206	1.72220168539e-25
ko04721	Synaptic vesicle cycle	53/1146	80/7206	3.24642319906e-24
ko04727	GABAergic synapse	62/1146	110/7206	1.27922117899e-22
ko04728	Dopaminergic synapse	84/1146	185/7206	7.36578732421e-22
ko04725	Cholinergic synapse	76/1146	160/7206	2.41427315947e-21
ko04723	Retrograde endocannabinoid signaling	76/1146	175/7206	1.80223208649e-18
ko04024	cAMP signaling pathway	103/1146	279/7206	2.83001291364e-18
ko04742	Taste transduction	39/1146	61/7206	2.53627776855e-17
ko04911	Insulin secretion	56/1146	117/7206	3.27904669655e-16
ko04921	Oxytocin signaling pathway	78/1146	209/7206	2.34417048111e-14
ko04020	Calcium signaling pathway	91/1146	265/7206	5.7399072534e-14
ko04726	Serotonergic synapse	58/1146	137/7206	8.85545580428e-14
ko04744	Phototransduction	25/1146	36/7206	8.77412967138e-13
ko05031	Amphetamine addiction	43/1146	91/7206	1.6806184172e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1146	205/7206	2.23718960634e-12
ko04720	Long-term potentiation	45/1146	99/7206	2.80957520564e-12
ko04740	Olfactory transduction	38/1146	80/7206	2.7573855617e-11
ko03040	Spliceosome	1/1146	145/7206	5.17411595903e-10
ko04360	Axon guidance	73/1146	233/7206	2.53729879479e-09
ko05030	Cocaine addiction	33/1146	73/7206	2.79238722696e-09
ko04970	Salivary secretion	39/1146	95/7206	3.17278036965e-09
ko04925	Aldosterone synthesis and secretion	40/1146	105/7206	3.63858636028e-08
ko05168	Herpes simplex infection	6/1146	182/7206	8.44662478886e-08
ko04060	Cytokine-cytokine receptor interaction	7/1146	191/7206	1.03764327811e-07
ko04971	Gastric acid secretion	37/1146	98/7206	1.49041863266e-07
ko04022	cGMP-PKG signaling pathway	63/1146	216/7206	6.04682280906e-07
ko03013	RNA transport	6/1146	166/7206	8.03957786777e-07
ko05203	Viral carcinogenesis	17/1146	277/7206	8.72632577212e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1146	74/7206	1.06906004302e-06
ko05164	Influenza A	7/1146	167/7206	2.83276225508e-06
ko04010	MAPK signaling pathway	83/1146	321/7206	3.30428446551e-06
ko04260	Cardiac muscle contraction	34/1146	98/7206	4.21506954577e-06
ko04966	Collecting duct acid secretion	14/1146	26/7206	8.95354415607e-06
ko04120	Ubiquitin mediated proteolysis	5/1146	138/7206	8.95496927986e-06
ko04141	Protein processing in endoplasmic reticulum	10/1146	184/7206	1.48439618747e-05
ko04924	Renin secretion	30/1146	86/7206	1.68193107748e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1146	79/7206	1.68913956201e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1146	79/7206	3.28156642543e-05
ko04621	NOD-like receptor signaling pathway	8/1146	157/7206	3.68147033843e-05
ko04540	Gap junction	39/1146	128/7206	4.02756947458e-05
ko04514	Cell adhesion molecules (CAMs)	39/1146	130/7206	4.7559940198e-05
ko05110	Vibrio cholerae infection	23/1146	63/7206	6.98722167392e-05
ko05162	Measles	5/1146	120/7206	7.81953133144e-05
ko05205	Proteoglycans in cancer	21/1146	271/7206	8.61467876054e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1146	59/7206	8.72992470412e-05
ko04745	Phototransduction - fly	16/1146	38/7206	0.000102976440455
ko05322	Systemic lupus erythematosus	8/1146	151/7206	0.000104630601611
ko04972	Pancreatic secretion	34/1146	111/7206	0.000106957292859
ko05414	Dilated cardiomyopathy	34/1146	112/7206	0.000117173653324
ko04730	Long-term depression	26/1146	78/7206	0.000124139781569
ko05169	Epstein-Barr virus infection	15/1146	206/7206	0.000307834218988
ko05140	Leishmaniasis	2/1146	75/7206	0.000388787919354
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1146	14/7206	0.000487562525263
ko04072	Phospholipase D signaling pathway	50/1146	197/7206	0.000497987996991
ko04110	Cell cycle	9/1146	145/7206	0.000525811541263
ko04976	Bile secretion	25/1146	80/7206	0.000552889924813
ko04070	Phosphatidylinositol signaling system	32/1146	112/7206	0.000602487783955
ko04064	NF-kappa B signaling pathway	4/1146	96/7206	0.000603626101725
ko04915	Estrogen signaling pathway	36/1146	131/7206	0.000642301175022
ko04750	Inflammatory mediator regulation of TRP channels	34/1146	122/7206	0.000659534013986
ko04014	Ras signaling pathway	65/1146	279/7206	0.00106365491639
ko04371	Apelin signaling pathway	45/1146	177/7206	0.00113198561204
ko04146	Peroxisome	4/1146	89/7206	0.00121904994268
ko00480	Glutathione metabolism	1/1146	55/7206	0.00132915641977
ko00590	Arachidonic acid metabolism	1/1146	52/7206	0.00200129208865
ko04640	Hematopoietic cell lineage	2/1146	64/7206	0.00284702587989
ko05161	Hepatitis B	14/1146	173/7206	0.00306561676653
ko04964	Proximal tubule bicarbonate reclamation	11/1146	29/7206	0.003392006091
ko00240	Pyrimidine metabolism	7/1146	110/7206	0.00361354520451
ko00260	Glycine, serine and threonine metabolism	1/1146	48/7206	0.00458381351842
ko05034	Alcoholism	54/1146	238/7206	0.00507952139671
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1146	100/7206	0.00529259985762
ko03022	Basal transcription factors	1/1146	44/7206	0.00678461625941
ko05144	Malaria	1/1146	45/7206	0.00679711366281
ko00071	Fatty acid degradation	1/1146	45/7206	0.00679711366281
ko01524	Platinum drug resistance	4/1146	76/7206	0.00696877903105
ko04612	Antigen processing and presentation	4/1146	77/7206	0.00703111735158
ko03420	Nucleotide excision repair	1/1146	46/7206	0.0070448556415
ko04657	IL-17 signaling pathway	5/1146	87/7206	0.00720427550454
ko04916	Melanogenesis	35/1146	142/7206	0.00720440208573
ko05321	Inflammatory bowel disease (IBD)	2/1146	56/7206	0.00882191773083
ko00310	Lysine degradation	4/1146	73/7206	0.00979950551967
ko03018	RNA degradation	5/1146	84/7206	0.0099130634325
ko04923	Regulation of lipolysis in adipocytes	21/1146	77/7206	0.0110749857573
ko04912	GnRH signaling pathway	30/1146	122/7206	0.0119832661792
ko04620	Toll-like receptor signaling pathway	7/1146	100/7206	0.0124497488334
ko05145	Toxoplasmosis	10/1146	126/7206	0.0132604368902
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1146	182/7206	0.0133334352975
ko00330	Arginine and proline metabolism	3/1146	61/7206	0.0133844803853
ko04622	RIG-I-like receptor signaling pathway	3/1146	62/7206	0.0134855234836
ko04214	Apoptosis - fly	4/1146	72/7206	0.0139341866641
ko05418	Fluid shear stress and atherosclerosis	16/1146	173/7206	0.0150084565318
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1146	40/7206	0.0152599500215
ko04630	Jak-STAT signaling pathway	11/1146	132/7206	0.0156326724069
ko04626	Plant-pathogen interaction	7/1146	18/7206	0.0160245126578
ko04658	Th1 and Th2 cell differentiation	7/1146	96/7206	0.0166149505248
ko04918	Thyroid hormone synthesis	22/1146	86/7206	0.0175304537004
ko05133	Pertussis	6/1146	87/7206	0.0177129953543
ko00380	Tryptophan metabolism	2/1146	50/7206	0.0181096655161
ko03320	PPAR signaling pathway	4/1146	69/7206	0.0192936240624
ko00982	Drug metabolism - cytochrome P450	1/1146	37/7206	0.0225872276729
ko03410	Base excision repair	1/1146	38/7206	0.0232114346488
ko04930	Type II diabetes mellitus	15/1146	54/7206	0.0237063775083
ko04015	Rap1 signaling pathway	58/1146	278/7206	0.0238914781564
ko04270	Vascular smooth muscle contraction	35/1146	154/7206	0.0252613188772
ko00620	Pyruvate metabolism	2/1146	46/7206	0.0258121628842
ko00270	Cysteine and methionine metabolism	2/1146	47/7206	0.0259721323349
ko04962	Vasopressin-regulated water reabsorption	16/1146	58/7206	0.0281320897958
ko04210	Apoptosis	18/1146	180/7206	0.0295941099594
ko04140	Autophagy - animal	16/1146	164/7206	0.0301656940953
ko05131	Shigellosis	6/1146	82/7206	0.032416968899
ko04115	p53 signaling pathway	5/1146	74/7206	0.0358127766622
ko00600	Sphingolipid metabolism	4/1146	63/7206	0.0367169784288
ko05206	MicroRNAs in cancer	18/1146	177/7206	0.0367836873028
ko00280	Valine, leucine and isoleucine degradation	3/1146	54/7206	0.0380408407573
ko05222	Small cell lung cancer	7/1146	89/7206	0.0398394432232
ko05166	HTLV-I infection	34/1146	292/7206	0.0411723292572
ko04350	TGF-beta signaling pathway	9/1146	103/7206	0.0421774551183
ko04670	Leukocyte transendothelial migration	15/1146	151/7206	0.0426593989614
ko04668	TNF signaling pathway	11/1146	120/7206	0.0433303169506
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1146	92/7206	0.0434246791892
ko05215	Prostate cancer	10/1146	111/7206	0.048826159739
ko04136	Autophagy - other	1/1146	31/7206	0.049798846589
ko01200	Carbon metabolism	12/1146	128/7206	0.0498074802003