ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	166/1005	423/7206	7.11217797958e-41
ko05033	Nicotine addiction	45/1005	56/7206	4.24464782271e-29
ko04724	Glutamatergic synapse	78/1005	152/7206	1.68270214011e-28
ko05032	Morphine addiction	62/1005	110/7206	8.67815592279e-26
ko04727	GABAergic synapse	58/1005	110/7206	3.27348958244e-22
ko04713	Circadian entrainment	65/1005	136/7206	1.04151602769e-21
ko04728	Dopaminergic synapse	78/1005	185/7206	1.45775273222e-21
ko04725	Cholinergic synapse	68/1005	160/7206	3.76733670372e-19
ko04723	Retrograde endocannabinoid signaling	71/1005	175/7206	1.37259621383e-18
ko04721	Synaptic vesicle cycle	44/1005	80/7206	4.54467478721e-18
ko04744	Phototransduction	26/1005	36/7206	2.68110585502e-15
ko04911	Insulin secretion	51/1005	117/7206	3.38502922405e-15
ko04024	cAMP signaling pathway	87/1005	279/7206	3.8455918682e-14
ko04726	Serotonergic synapse	54/1005	137/7206	8.68339821484e-14
ko04742	Taste transduction	32/1005	61/7206	9.99344161165e-13
ko04921	Oxytocin signaling pathway	68/1005	209/7206	3.24919818243e-12
ko04020	Calcium signaling pathway	79/1005	265/7206	1.10843740903e-11
ko05031	Amphetamine addiction	37/1005	91/7206	2.60766219143e-10
ko04261	Adrenergic signaling in cardiomyocytes	61/1005	205/7206	2.3490561225e-09
ko04720	Long-term potentiation	37/1005	99/7206	4.27497779951e-09
ko03040	Spliceosome	1/1005	145/7206	1.4906639379e-08
ko04970	Salivary secretion	35/1005	95/7206	1.73141611435e-08
ko04971	Gastric acid secretion	34/1005	98/7206	1.52824757478e-07
ko05030	Cocaine addiction	28/1005	73/7206	1.74987334373e-07
ko04360	Axon guidance	62/1005	233/7206	2.15699808931e-07
ko04925	Aldosterone synthesis and secretion	34/1005	105/7206	1.10210057532e-06
ko04740	Olfactory transduction	28/1005	80/7206	1.55760483009e-06
ko05203	Viral carcinogenesis	14/1005	277/7206	2.0568869472e-06
ko04514	Cell adhesion molecules (CAMs)	39/1005	130/7206	2.11181189607e-06
ko05164	Influenza A	5/1005	167/7206	2.40821239642e-06
ko05322	Systemic lupus erythematosus	4/1005	151/7206	3.99050586622e-06
ko04070	Phosphatidylinositol signaling system	34/1005	112/7206	5.84603139574e-06
ko04730	Long-term depression	26/1005	78/7206	1.01743730401e-05
ko04621	NOD-like receptor signaling pathway	5/1005	157/7206	1.09539892688e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1005	74/7206	1.15095246389e-05
ko04972	Pancreatic secretion	33/1005	111/7206	1.22410908737e-05
ko03013	RNA transport	6/1005	166/7206	1.25643063793e-05
ko04120	Ubiquitin mediated proteolysis	4/1005	138/7206	1.76298081432e-05
ko04745	Phototransduction - fly	16/1005	38/7206	1.97587787823e-05
ko05168	Herpes simplex infection	8/1005	182/7206	3.11864094912e-05
ko04060	Cytokine-cytokine receptor interaction	9/1005	191/7206	4.62559873508e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1005	79/7206	0.000126232758881
ko04022	cGMP-PKG signaling pathway	50/1005	216/7206	0.000200295949685
ko04010	MAPK signaling pathway	68/1005	321/7206	0.000269852788392
ko04141	Protein processing in endoplasmic reticulum	10/1005	184/7206	0.000321917195962
ko04966	Collecting duct acid secretion	11/1005	26/7206	0.000381057618977
ko04540	Gap junction	32/1005	128/7206	0.00071217145907
ko04014	Ras signaling pathway	59/1005	279/7206	0.000763777191643
ko05161	Hepatitis B	10/1005	173/7206	0.000792156311042
ko04750	Inflammatory mediator regulation of TRP channels	31/1005	122/7206	0.000809837725002
ko04260	Cardiac muscle contraction	26/1005	98/7206	0.000988135749586
ko04964	Proximal tubule bicarbonate reclamation	11/1005	29/7206	0.00114505034028
ko04612	Antigen processing and presentation	2/1005	77/7206	0.0014095537706
ko04924	Renin secretion	23/1005	86/7206	0.00147927234672
ko05169	Epstein-Barr virus infection	14/1005	206/7206	0.00149438135814
ko04610	Complement and coagulation cascades	2/1005	79/7206	0.00149898491374
ko03008	Ribosome biogenesis in eukaryotes	2/1005	79/7206	0.00149898491374
ko05162	Measles	6/1005	120/7206	0.00212913365477
ko04072	Phospholipase D signaling pathway	43/1005	197/7206	0.00231726037304
ko04064	NF-kappa B signaling pathway	4/1005	96/7206	0.00273588842793
ko04915	Estrogen signaling pathway	31/1005	131/7206	0.00304940992194
ko04976	Bile secretion	21/1005	80/7206	0.00307304404629
ko05205	Proteoglycans in cancer	22/1005	271/7206	0.00404551526095
ko05110	Vibrio cholerae infection	17/1005	63/7206	0.00545102967202
ko05166	HTLV-I infection	25/1005	292/7206	0.00561669116066
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1005	59/7206	0.00704998700017
ko04626	Plant-pathogen interaction	7/1005	18/7206	0.00786729039937
ko04146	Peroxisome	4/1005	89/7206	0.00791117215276
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1005	14/7206	0.00800826191309
ko05414	Dilated cardiomyopathy	26/1005	112/7206	0.00824518723603
ko04640	Hematopoietic cell lineage	2/1005	64/7206	0.00966405879871
ko05140	Leishmaniasis	3/1005	75/7206	0.0106362676283
ko04110	Cell cycle	10/1005	145/7206	0.0106472852071
ko00260	Glycine, serine and threonine metabolism	1/1005	48/7206	0.0109754516631
ko05219	Bladder cancer	1/1005	48/7206	0.0109754516631
ko04710	Circadian rhythm	12/1005	43/7206	0.0137537807839
ko00330	Arginine and proline metabolism	2/1005	61/7206	0.0139372822559
ko04630	Jak-STAT signaling pathway	9/1005	132/7206	0.0153241191865
ko05016	Huntington's disease	18/1005	215/7206	0.0160060268432
ko00071	Fatty acid degradation	1/1005	45/7206	0.0162686447943
ko03420	Nucleotide excision repair	1/1005	46/7206	0.0165994711172
ko04510	Focal adhesion	21/1005	240/7206	0.0174467583413
ko00240	Pyrimidine metabolism	7/1005	110/7206	0.017800575971
ko04371	Apelin signaling pathway	36/1005	177/7206	0.0203273720745
ko03320	PPAR signaling pathway	3/1005	69/7206	0.0211964388337
ko05231	Choline metabolism in cancer	28/1005	134/7206	0.0233031059497
ko04960	Aldosterone-regulated sodium reabsorption	11/1005	41/7206	0.023664311476
ko04658	Th1 and Th2 cell differentiation	6/1005	96/7206	0.0254974006543
ko03022	Basal transcription factors	1/1005	44/7206	0.0255257098851
ko05410	Hypertrophic cardiomyopathy (HCM)	22/1005	100/7206	0.0278499799161
ko00280	Valine, leucine and isoleucine degradation	2/1005	54/7206	0.0278709103623
ko04115	p53 signaling pathway	4/1005	74/7206	0.0281765670442
ko04217	Necroptosis	15/1005	178/7206	0.0284553629283
ko00480	Glutathione metabolism	2/1005	55/7206	0.0287425554642
ko00562	Inositol phosphate metabolism	20/1005	89/7206	0.0294224227657
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1005	40/7206	0.0361689849203
ko05200	Pathways in cancer	53/1005	492/7206	0.0364246484139
ko05131	Shigellosis	5/1005	82/7206	0.0366460931203
ko05215	Prostate cancer	8/1005	111/7206	0.0378037905073
ko04214	Apoptosis - fly	4/1005	72/7206	0.0388536772551
ko00310	Lysine degradation	4/1005	73/7206	0.0394541603268
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1005	182/7206	0.0396212736076
ko04973	Carbohydrate digestion and absorption	11/1005	42/7206	0.0397025174812
ko04330	Notch signaling pathway	3/1005	62/7206	0.0405023429595
ko04622	RIG-I-like receptor signaling pathway	3/1005	62/7206	0.0405023429595
ko00590	Arachidonic acid metabolism	2/1005	52/7206	0.0410736235978
ko04668	TNF signaling pathway	9/1005	120/7206	0.0448873621187
ko04930	Type II diabetes mellitus	13/1005	54/7206	0.0453800521148
ko05222	Small cell lung cancer	6/1005	89/7206	0.0455615320102
ko04923	Regulation of lipolysis in adipocytes	17/1005	77/7206	0.0462930439503
ko04210	Apoptosis	16/1005	180/7206	0.0493306212229