ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1261	423/7206	6.02713088794e-55
ko04724	Glutamatergic synapse	91/1261	152/7206	3.00753721004e-32
ko04713	Circadian entrainment	85/1261	136/7206	3.79204548799e-32
ko05033	Nicotine addiction	50/1261	56/7206	6.8576203509e-32
ko05032	Morphine addiction	74/1261	110/7206	3.15393601107e-31
ko04727	GABAergic synapse	70/1261	110/7206	2.46218234688e-27
ko04725	Cholinergic synapse	80/1261	160/7206	1.76361631393e-21
ko04728	Dopaminergic synapse	86/1261	185/7206	2.4655515166e-20
ko04020	Calcium signaling pathway	109/1261	265/7206	2.69262696217e-20
ko04721	Synaptic vesicle cycle	50/1261	80/7206	2.39803963875e-19
ko04723	Retrograde endocannabinoid signaling	81/1261	175/7206	4.57079778409e-19
ko04024	cAMP signaling pathway	110/1261	279/7206	8.74261775857e-19
ko04911	Insulin secretion	59/1261	117/7206	2.31420445002e-16
ko04742	Taste transduction	38/1261	61/7206	6.18282351757e-15
ko04726	Serotonergic synapse	63/1261	137/7206	6.45691246685e-15
ko04921	Oxytocin signaling pathway	82/1261	209/7206	4.07474780378e-14
ko04744	Phototransduction	27/1261	36/7206	5.33149007224e-14
ko04970	Salivary secretion	47/1261	95/7206	6.74646160702e-13
ko04740	Olfactory transduction	42/1261	80/7206	8.85194811512e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1261	205/7206	1.83090905489e-12
ko05031	Amphetamine addiction	43/1261	91/7206	4.52662569238e-11
ko04720	Long-term potentiation	45/1261	99/7206	8.24339299927e-11
ko03040	Spliceosome	2/1261	145/7206	6.01033061269e-10
ko04022	cGMP-PKG signaling pathway	75/1261	216/7206	7.88406079483e-10
ko04925	Aldosterone synthesis and secretion	43/1261	105/7206	1.26516356085e-08
ko05322	Systemic lupus erythematosus	4/1261	151/7206	1.46580184736e-08
ko05203	Viral carcinogenesis	17/1261	277/7206	2.64527295932e-08
ko04971	Gastric acid secretion	39/1261	98/7206	1.41015803446e-07
ko03013	RNA transport	7/1261	166/7206	2.52202682726e-07
ko05030	Cocaine addiction	31/1261	73/7206	4.81423520385e-07
ko04360	Axon guidance	71/1261	233/7206	1.02386630936e-06
ko04730	Long-term depression	31/1261	78/7206	2.96550321818e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1261	74/7206	2.99323791941e-06
ko04540	Gap junction	44/1261	128/7206	3.13331646985e-06
ko04072	Phospholipase D signaling pathway	60/1261	197/7206	6.07002837929e-06
ko04924	Renin secretion	32/1261	86/7206	1.08366909333e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1261	122/7206	1.72720847577e-05
ko04745	Phototransduction - fly	18/1261	38/7206	2.04362148616e-05
ko04010	MAPK signaling pathway	86/1261	321/7206	2.25615990579e-05
ko04070	Phosphatidylinositol signaling system	38/1261	112/7206	2.39020758084e-05
ko04966	Collecting duct acid secretion	14/1261	26/7206	2.79008766241e-05
ko04371	Apelin signaling pathway	53/1261	177/7206	3.43853041804e-05
ko04710	Circadian rhythm	19/1261	43/7206	4.10078946938e-05
ko04711	Circadian rhythm - fly	9/1261	13/7206	5.44887751492e-05
ko04060	Cytokine-cytokine receptor interaction	14/1261	191/7206	6.37011378602e-05
ko05168	Herpes simplex infection	13/1261	182/7206	6.52967219691e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1261	79/7206	7.04845457196e-05
ko05414	Dilated cardiomyopathy	37/1261	112/7206	7.37016967828e-05
ko04110	Cell cycle	9/1261	145/7206	9.18259258869e-05
ko04514	Cell adhesion molecules (CAMs)	41/1261	130/7206	9.32037915297e-05
ko04972	Pancreatic secretion	36/1261	111/7206	0.000120976604936
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1261	79/7206	0.000131100889876
ko04976	Bile secretion	28/1261	80/7206	0.000152333514789
ko04141	Protein processing in endoplasmic reticulum	14/1261	184/7206	0.000161064633693
ko04621	NOD-like receptor signaling pathway	11/1261	157/7206	0.000175370669309
ko05164	Influenza A	12/1261	167/7206	0.000175549140046
ko04260	Cardiac muscle contraction	32/1261	98/7206	0.000238133299913
ko04120	Ubiquitin mediated proteolysis	9/1261	138/7206	0.00024869877598
ko05110	Vibrio cholerae infection	23/1261	63/7206	0.000311104556308
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1261	59/7206	0.00037885085397
ko04014	Ras signaling pathway	72/1261	279/7206	0.000380492509028
ko05169	Epstein-Barr virus infection	18/1261	206/7206	0.000382534378536
ko00520	Amino sugar and nucleotide sugar metabolism	1/1261	55/7206	0.000523477942704
ko05140	Leishmaniasis	3/1261	75/7206	0.000656012008663
ko04923	Regulation of lipolysis in adipocytes	26/1261	77/7206	0.00069849245304
ko05205	Proteoglycans in cancer	28/1261	271/7206	0.00106346687168
ko04064	NF-kappa B signaling pathway	6/1261	96/7206	0.00174311135
ko04612	Antigen processing and presentation	4/1261	77/7206	0.00226027353368
ko05162	Measles	9/1261	120/7206	0.0022674252109
ko04915	Estrogen signaling pathway	37/1261	131/7206	0.00230913230756
ko04270	Vascular smooth muscle contraction	42/1261	154/7206	0.00247428343722
ko04657	IL-17 signaling pathway	5/1261	87/7206	0.00247622763827
ko00071	Fatty acid degradation	1/1261	45/7206	0.0027582150719
ko03420	Nucleotide excision repair	1/1261	46/7206	0.00279218972055
ko00240	Pyrimidine metabolism	8/1261	110/7206	0.00328613236943
ko05166	HTLV-I infection	33/1261	292/7206	0.00354295888928
ko05321	Inflammatory bowel disease (IBD)	2/1261	56/7206	0.00387319398527
ko03022	Basal transcription factors	1/1261	44/7206	0.00428328290899
ko00310	Lysine degradation	4/1261	73/7206	0.00467834717799
ko04146	Peroxisome	6/1261	89/7206	0.00468866228288
ko05131	Shigellosis	5/1261	82/7206	0.00486339768145
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1261	100/7206	0.0048643693395
ko00590	Arachidonic acid metabolism	2/1261	52/7206	0.00537879077287
ko05161	Hepatitis B	17/1261	173/7206	0.00599595028003
ko04622	RIG-I-like receptor signaling pathway	3/1261	62/7206	0.00630304638905
ko04658	Th1 and Th2 cell differentiation	7/1261	96/7206	0.00632098073165
ko05133	Pertussis	6/1261	87/7206	0.0065029053332
ko04610	Complement and coagulation cascades	5/1261	79/7206	0.00667698044442
ko04626	Plant-pathogen interaction	8/1261	18/7206	0.00717112742871
ko03018	RNA degradation	6/1261	84/7206	0.00892075095719
ko03410	Base excision repair	1/1261	38/7206	0.00945516337118
ko04930	Type II diabetes mellitus	17/1261	54/7206	0.0109110101849
ko04912	GnRH signaling pathway	32/1261	122/7206	0.0155515176987
ko04217	Necroptosis	19/1261	178/7206	0.0160163012092
ko05144	Malaria	2/1261	45/7206	0.0168905516564
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1261	182/7206	0.0175234814937
ko00280	Valine, leucine and isoleucine degradation	3/1261	54/7206	0.018071457124
ko04922	Glucagon signaling pathway	33/1261	128/7206	0.018224685182
ko05231	Choline metabolism in cancer	34/1261	134/7206	0.021064943368
ko00860	Porphyrin and chlorophyll metabolism	1/1261	34/7206	0.021512013554
ko05016	Huntington's disease	25/1261	215/7206	0.0222903058597
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1261	14/7206	0.0238375311449
ko04015	Rap1 signaling pathway	63/1261	278/7206	0.0240602496563
ko05217	Basal cell carcinoma	5/1261	68/7206	0.024144842234
ko04964	Proximal tubule bicarbonate reclamation	10/1261	29/7206	0.024782614477
ko00330	Arginine and proline metabolism	4/1261	61/7206	0.0259377667121
ko04115	p53 signaling pathway	6/1261	74/7206	0.0307548398518
ko04213	Longevity regulating pathway - multiple species	23/1261	86/7206	0.0311210011664
ko04918	Thyroid hormone synthesis	23/1261	86/7206	0.0311210011664
ko05215	Prostate cancer	11/1261	111/7206	0.0321496772899
ko05145	Toxoplasmosis	13/1261	126/7206	0.0326701428441
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1261	40/7206	0.0355002796356
ko00260	Glycine, serine and threonine metabolism	3/1261	48/7206	0.03600070993
ko05219	Bladder cancer	3/1261	48/7206	0.03600070993
ko00140	Steroid hormone biosynthesis	2/1261	41/7206	0.0363722134207
ko00380	Tryptophan metabolism	3/1261	50/7206	0.0372829047381
ko04142	Lysosome	17/1261	151/7206	0.0398042188539
ko04214	Apoptosis - fly	6/1261	72/7206	0.0415722271872
ko04620	Toll-like receptor signaling pathway	10/1261	100/7206	0.046658250824
ko04071	Sphingolipid signaling pathway	38/1261	162/7206	0.0470483603879
ko00480	Glutathione metabolism	4/1261	55/7206	0.0485220049424