ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 40/372 191/7206 9.50837038071e-15 ko05340 Primary immunodeficiency 15/372 30/7206 2.85221321143e-12 ko05162 Measles 26/372 120/7206 2.53189655571e-10 ko05164 Influenza A 30/372 167/7206 1.31485426452e-09 ko04650 Natural killer cell mediated cytotoxicity 22/372 97/7206 2.53023118509e-09 ko05140 Leishmaniasis 19/372 75/7206 4.43587789289e-09 ko04621 NOD-like receptor signaling pathway 27/372 157/7206 2.39925150157e-08 ko05168 Herpes simplex infection 29/372 182/7206 4.18947272619e-08 ko04380 Osteoclast differentiation 24/372 134/7206 6.6173759789e-08 ko05321 Inflammatory bowel disease (IBD) 15/372 56/7206 8.67900983424e-08 ko05145 Toxoplasmosis 23/372 126/7206 8.69648414753e-08 ko05320 Autoimmune thyroid disease 11/372 29/7206 8.94363272256e-08 ko05330 Allograft rejection 10/372 24/7206 1.22086157525e-07 ko04612 Antigen processing and presentation 17/372 77/7206 2.58813946058e-07 ko05152 Tuberculosis 28/372 187/7206 2.78273554807e-07 ko04659 Th17 cell differentiation 20/372 106/7206 3.52160051114e-07 ko04620 Toll-like receptor signaling pathway 19/372 100/7206 6.2043260851e-07 ko05150 Staphylococcus aureus infection 11/372 36/7206 1.11889190072e-06 ko05332 Graft-versus-host disease 8/372 18/7206 1.29813705104e-06 ko04217 Necroptosis 25/372 178/7206 4.07826524508e-06 ko04630 Jak-STAT signaling pathway 20/372 132/7206 1.21865324835e-05 ko05144 Malaria 11/372 45/7206 1.24121901417e-05 ko04660 T cell receptor signaling pathway 19/372 124/7206 1.70931710968e-05 ko04640 Hematopoietic cell lineage 13/372 64/7206 1.7826517356e-05 ko04658 Th1 and Th2 cell differentiation 16/372 96/7206 2.74269724112e-05 ko04064 NF-kappa B signaling pathway 16/372 96/7206 2.74269724112e-05 ko05034 Alcoholism 1/372 238/7206 7.19333013452e-05 ko04672 Intestinal immune network for IgA production 9/372 37/7206 8.09836892336e-05 ko05133 Pertussis 14/372 87/7206 0.000128675802948 ko04940 Type I diabetes mellitus 8/372 32/7206 0.000164798790871 ko04610 Complement and coagulation cascades 13/372 79/7206 0.000177042567827 ko04137 Mitophagy - animal 13/372 82/7206 0.000260000615121 ko04622 RIG-I-like receptor signaling pathway 11/372 62/7206 0.000281688361891 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/372 191/7206 0.000351895060511 ko03050 Proteasome 10/372 54/7206 0.000370586761726 ko00120 Primary bile acid biosynthesis 6/372 20/7206 0.000379726632768 ko04360 Axon guidance 2/372 233/7206 0.000730564027294 ko04145 Phagosome 19/372 162/7206 0.000811505519981 ko04062 Chemokine signaling pathway 22/372 201/7206 0.000893710362261 ko04310 Wnt signaling pathway 1/372 181/7206 0.0010602887853 ko04728 Dopaminergic synapse 1/372 185/7206 0.00107538720549 ko05310 Asthma 5/372 17/7206 0.00131828754828 ko04662 B cell receptor signaling pathway 12/372 88/7206 0.0017565971577 ko03013 RNA transport 1/372 166/7206 0.00226263409346 ko05142 Chagas disease (American trypanosomiasis) 15/372 130/7206 0.00369607154826 ko04514 Cell adhesion molecules (CAMs) 15/372 130/7206 0.00369607154826 ko05132 Salmonella infection 12/372 98/7206 0.00437269591621 ko05161 Hepatitis B 18/372 173/7206 0.00442499358774 ko04623 Cytosolic DNA-sensing pathway 7/372 41/7206 0.0045298547521 ko00590 Arachidonic acid metabolism 8/372 52/7206 0.00478197298527 ko04146 Peroxisome 11/372 89/7206 0.0058194260676 ko05323 Rheumatoid arthritis 11/372 89/7206 0.0058194260676 ko04390 Hippo signaling pathway 2/372 188/7206 0.00644140348736 ko03040 Spliceosome 1/372 145/7206 0.00701243893033 ko04110 Cell cycle 1/372 145/7206 0.00701243893033 ko04723 Retrograde endocannabinoid signaling 2/372 175/7206 0.00873083727409 ko04611 Platelet activation 16/372 163/7206 0.0113907676633 ko00592 alpha-Linolenic acid metabolism 4/372 19/7206 0.0146082245679 ko03010 Ribosome 1/372 129/7206 0.014709513466 ko00051 Fructose and mannose metabolism 6/372 42/7206 0.0197383266485 ko05416 Viral myocarditis 7/372 55/7206 0.0220958296273 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/372 5/7206 0.023955011855 ko04666 Fc gamma R-mediated phagocytosis 12/372 122/7206 0.0345831058475 ko05010 Alzheimer's disease 4/372 202/7206 0.0348906452065 ko04910 Insulin signaling pathway 3/372 172/7206 0.0354423941151 ko05224 Breast cancer 3/372 174/7206 0.0356568883384 ko05206 MicroRNAs in cancer 3/372 177/7206 0.0364179425397 ko04024 cAMP signaling pathway 7/372 279/7206 0.0379769545325 ko05160 Hepatitis C 14/372 153/7206 0.0387106688904 ko00511 Other glycan degradation 4/372 26/7206 0.042481141838 ko04925 Aldosterone synthesis and secretion 1/372 105/7206 0.0440900062302 ko04727 GABAergic synapse 1/372 110/7206 0.0459263893659 ko04972 Pancreatic secretion 1/372 111/7206 0.0466168262508 ko04713 Circadian entrainment 2/372 136/7206 0.0483441533019 ko04550 Signaling pathways regulating pluripotency of stem cells 3/372 165/7206 0.0486533891092