ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1159	423/7206	9.94886049553e-44
ko04724	Glutamatergic synapse	82/1159	152/7206	1.88085825428e-27
ko05033	Nicotine addiction	42/1159	56/7206	1.42154921567e-22
ko04713	Circadian entrainment	67/1159	136/7206	9.39131607144e-20
ko05032	Morphine addiction	58/1159	110/7206	4.4409846659e-19
ko04020	Calcium signaling pathway	100/1159	265/7206	2.92716717155e-18
ko04728	Dopaminergic synapse	77/1159	185/7206	4.16284624939e-17
ko04727	GABAergic synapse	54/1159	110/7206	4.60416548091e-16
ko04725	Cholinergic synapse	67/1159	160/7206	3.44232474907e-15
ko04721	Synaptic vesicle cycle	43/1159	80/7206	7.33697758703e-15
ko04911	Insulin secretion	53/1159	117/7206	5.98415176801e-14
ko04726	Serotonergic synapse	58/1159	137/7206	1.46685784809e-13
ko04024	cAMP signaling pathway	94/1159	279/7206	1.88817470885e-13
ko04921	Oxytocin signaling pathway	76/1159	209/7206	4.32393155592e-13
ko04723	Retrograde endocannabinoid signaling	67/1159	175/7206	6.35587306448e-13
ko04742	Taste transduction	32/1159	61/7206	5.07746915549e-11
ko05031	Amphetamine addiction	39/1159	91/7206	9.87129280892e-10
ko04970	Salivary secretion	39/1159	95/7206	4.41856207471e-09
ko03010	Ribosome	1/1159	129/7206	6.89551361846e-09
ko05322	Systemic lupus erythematosus	3/1159	151/7206	1.73527247028e-08
ko04720	Long-term potentiation	39/1159	99/7206	1.76179580581e-08
ko03040	Spliceosome	3/1159	145/7206	6.17823166658e-08
ko04744	Phototransduction	20/1159	36/7206	6.26813970876e-08
ko04971	Gastric acid secretion	38/1159	98/7206	7.47437843532e-08
ko04925	Aldosterone synthesis and secretion	39/1159	105/7206	1.24591111748e-07
ko04261	Adrenergic signaling in cardiomyocytes	62/1159	205/7206	3.22642896804e-07
ko04022	cGMP-PKG signaling pathway	64/1159	216/7206	4.05926555456e-07
ko04120	Ubiquitin mediated proteolysis	4/1159	138/7206	9.63023669328e-07
ko05168	Herpes simplex infection	8/1159	182/7206	1.07958456456e-06
ko05164	Influenza A	7/1159	167/7206	1.92544206548e-06
ko03013	RNA transport	7/1159	166/7206	2.83382793534e-06
ko05030	Cocaine addiction	28/1159	73/7206	3.40073841623e-06
ko04730	Long-term depression	28/1159	78/7206	1.60040172572e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1159	74/7206	1.71758471544e-05
ko04070	Phosphatidylinositol signaling system	36/1159	112/7206	2.18651175691e-05
ko04621	NOD-like receptor signaling pathway	8/1159	157/7206	3.69141535334e-05
ko04972	Pancreatic secretion	35/1159	111/7206	4.07240214259e-05
ko04110	Cell cycle	7/1159	145/7206	4.86447632524e-05
ko04360	Axon guidance	61/1159	233/7206	5.86336398117e-05
ko05203	Viral carcinogenesis	22/1159	277/7206	7.78797179819e-05
ko04740	Olfactory transduction	27/1159	80/7206	8.61016320214e-05
ko04976	Bile secretion	27/1159	80/7206	8.61016320214e-05
ko04745	Phototransduction - fly	16/1159	38/7206	0.000118262331929
ko04141	Protein processing in endoplasmic reticulum	12/1159	184/7206	0.000142958630276
ko04514	Cell adhesion molecules (CAMs)	38/1159	130/7206	0.000148135351099
ko04010	MAPK signaling pathway	77/1159	321/7206	0.000176623553697
ko04710	Circadian rhythm	17/1159	43/7206	0.000184960280197
ko04964	Proximal tubule bicarbonate reclamation	13/1159	29/7206	0.000242833855631
ko03008	Ribosome biogenesis in eukaryotes	2/1159	79/7206	0.000277197521653
ko04750	Inflammatory mediator regulation of TRP channels	35/1159	122/7206	0.000413397122423
ko04060	Cytokine-cytokine receptor interaction	14/1159	191/7206	0.000427299344712
ko05161	Hepatitis B	12/1159	173/7206	0.000481242733929
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1159	79/7206	0.000537299293362
ko04540	Gap junction	36/1159	128/7206	0.000566570431308
ko04371	Apelin signaling pathway	46/1159	177/7206	0.0005854819776
ko04630	Jak-STAT signaling pathway	8/1159	132/7206	0.000721240644552
ko04072	Phospholipase D signaling pathway	50/1159	197/7206	0.000747568880382
ko04924	Renin secretion	26/1159	86/7206	0.00094442325526
ko04922	Glucagon signaling pathway	35/1159	128/7206	0.000972736638866
ko05162	Measles	7/1159	120/7206	0.000994520229517
ko04966	Collecting duct acid secretion	11/1159	26/7206	0.00131867544946
ko00520	Amino sugar and nucleotide sugar metabolism	1/1159	55/7206	0.00132938002571
ko04270	Vascular smooth muscle contraction	40/1159	154/7206	0.00171896069738
ko04930	Type II diabetes mellitus	18/1159	54/7206	0.00219276512962
ko05140	Leishmaniasis	3/1159	75/7206	0.00224674172842
ko05169	Epstein-Barr virus infection	18/1159	206/7206	0.00270227162028
ko04217	Necroptosis	15/1159	178/7206	0.00362877186988
ko05414	Dilated cardiomyopathy	30/1159	112/7206	0.00391985663765
ko04626	Plant-pathogen interaction	8/1159	18/7206	0.00421032130622
ko03420	Nucleotide excision repair	1/1159	46/7206	0.00449384991319
ko05145	Toxoplasmosis	9/1159	126/7206	0.00451837058437
ko04014	Ras signaling pathway	62/1159	279/7206	0.00597542402763
ko03022	Basal transcription factors	1/1159	44/7206	0.00670636735297
ko05144	Malaria	1/1159	45/7206	0.00683497358103
ko04612	Antigen processing and presentation	4/1159	77/7206	0.0071426562355
ko04064	NF-kappa B signaling pathway	6/1159	96/7206	0.00716176964487
ko04915	Estrogen signaling pathway	33/1159	131/7206	0.0077368644993
ko04260	Cardiac muscle contraction	26/1159	98/7206	0.00789457054551
ko00280	Valine, leucine and isoleucine degradation	2/1159	54/7206	0.00841217623553
ko05166	HTLV-I infection	31/1159	292/7206	0.00903447326011
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1159	59/7206	0.0119331584446
ko00590	Arachidonic acid metabolism	2/1159	52/7206	0.0123810849975
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1159	100/7206	0.0126882010798
ko05222	Small cell lung cancer	6/1159	89/7206	0.0129607401469
ko04622	RIG-I-like receptor signaling pathway	3/1159	62/7206	0.0136314466408
ko04916	Melanogenesis	34/1159	142/7206	0.0147875220298
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1159	14/7206	0.0160234754053
ko04960	Aldosterone-regulated sodium reabsorption	13/1159	41/7206	0.0162287280467
ko05219	Bladder cancer	2/1159	48/7206	0.017762178493
ko04657	IL-17 signaling pathway	6/1159	87/7206	0.0177893720518
ko05133	Pertussis	6/1159	87/7206	0.0177893720518
ko01524	Platinum drug resistance	5/1159	76/7206	0.0184986314992
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1159	182/7206	0.0186848512241
ko05205	Proteoglycans in cancer	30/1159	271/7206	0.0225209478209
ko00630	Glyoxylate and dicarboxylate metabolism	1/1159	38/7206	0.0235479426641
ko03410	Base excision repair	1/1159	38/7206	0.0235479426641
ko05110	Vibrio cholerae infection	17/1159	63/7206	0.024311978016
ko04115	p53 signaling pathway	5/1159	74/7206	0.0253051684764
ko05321	Inflammatory bowel disease (IBD)	3/1159	56/7206	0.0268600742191
ko04620	Toll-like receptor signaling pathway	8/1159	100/7206	0.0272579936321
ko04962	Vasopressin-regulated water reabsorption	16/1159	58/7206	0.0288506488507
ko04146	Peroxisome	7/1159	89/7206	0.029606861204
ko05016	Huntington's disease	23/1159	215/7206	0.0297600679237
ko05131	Shigellosis	6/1159	82/7206	0.0327291629086
ko00860	Porphyrin and chlorophyll metabolism	1/1159	34/7206	0.0334186894058
ko04214	Apoptosis - fly	5/1159	72/7206	0.0347215403606
ko00310	Lysine degradation	5/1159	73/7206	0.035451631538
ko04658	Th1 and Th2 cell differentiation	8/1159	96/7206	0.0356222479046
ko05215	Prostate cancer	10/1159	111/7206	0.0375679134
ko00071	Fatty acid degradation	2/1159	45/7206	0.0385169901063
ko04918	Thyroid hormone synthesis	21/1159	86/7206	0.0389541048292
ko04210	Apoptosis	19/1159	180/7206	0.0398340382633
ko00562	Inositol phosphate metabolism	22/1159	89/7206	0.0404139156903
ko05200	Pathways in cancer	63/1159	492/7206	0.0417668531511
ko04670	Leukocyte transendothelial migration	15/1159	151/7206	0.0429620894798
ko05130	Pathogenic Escherichia coli infection	6/1159	77/7206	0.0431216873135
ko04610	Complement and coagulation cascades	6/1159	79/7206	0.0436409309354
ko04668	TNF signaling pathway	11/1159	120/7206	0.0437572879323
ko04711	Circadian rhythm - fly	5/1159	13/7206	0.0445523709855
ko00240	Pyrimidine metabolism	10/1159	110/7206	0.0487132228063