ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 15/131 152/7206 8.48577622916e-08 ko04020 Calcium signaling pathway 18/131 265/7206 1.20034192173e-06 ko05030 Cocaine addiction 9/131 73/7206 5.98013799931e-06 ko04072 Phospholipase D signaling pathway 14/131 197/7206 1.20760513592e-05 ko04727 GABAergic synapse 10/131 110/7206 2.80658134148e-05 ko05032 Morphine addiction 10/131 110/7206 2.80658134148e-05 ko04728 Dopaminergic synapse 13/131 185/7206 2.83800145654e-05 ko04725 Cholinergic synapse 12/131 160/7206 3.07652002723e-05 ko04713 Circadian entrainment 11/131 136/7206 3.32601001244e-05 ko05031 Amphetamine addiction 9/131 91/7206 3.66431985021e-05 ko04911 Insulin secretion 10/131 117/7206 4.79343544128e-05 ko05033 Nicotine addiction 7/131 56/7206 6.17590932796e-05 ko04720 Long-term potentiation 9/131 99/7206 7.16026964177e-05 ko04261 Adrenergic signaling in cardiomyocytes 13/131 205/7206 8.26306241504e-05 ko04742 Taste transduction 7/131 61/7206 0.000107741836344 ko04925 Aldosterone synthesis and secretion 9/131 105/7206 0.000113399517869 ko04915 Estrogen signaling pathway 10/131 131/7206 0.000125002148112 ko04024 cAMP signaling pathway 15/131 279/7206 0.000150907049568 ko05231 Choline metabolism in cancer 10/131 134/7206 0.000150922607604 ko04211 Longevity regulating pathway 9/131 123/7206 0.000377158004222 ko04070 Phosphatidylinositol signaling system 8/131 112/7206 0.000939033330503 ko00515 Mannose type O-glycan biosynthesis 4/131 25/7206 0.00098120252539 ko04360 Axon guidance 12/131 233/7206 0.00103856332668 ko04723 Retrograde endocannabinoid signaling 10/131 175/7206 0.00126092465422 ko04912 GnRH signaling pathway 8/131 122/7206 0.00163451868591 ko04022 cGMP-PKG signaling pathway 11/131 216/7206 0.00184189083206 ko04080 Neuroactive ligand-receptor interaction 17/131 423/7206 0.00194178681736 ko04011 MAPK signaling pathway - yeast 5/131 53/7206 0.00262395684176 ko04923 Regulation of lipolysis in adipocytes 6/131 77/7206 0.00265532603903 ko04914 Progesterone-mediated oocyte maturation 7/131 104/7206 0.0027510644802 ko04740 Olfactory transduction 6/131 80/7206 0.00321988193963 ko05414 Dilated cardiomyopathy 7/131 112/7206 0.00416319136991 ko04139 Mitophagy - yeast 4/131 37/7206 0.00432983068037 ko04015 Rap1 signaling pathway 12/131 278/7206 0.00453210018753 ko04213 Longevity regulating pathway - multiple species 6/131 86/7206 0.00461191288305 ko04666 Fc gamma R-mediated phagocytosis 7/131 122/7206 0.00663151339515 ko01522 Endocrine resistance 7/131 124/7206 0.00723378286781 ko04970 Salivary secretion 6/131 95/7206 0.00746979762029 ko04540 Gap junction 7/131 128/7206 0.00855898168109 ko04971 Gastric acid secretion 6/131 98/7206 0.00865777579348 ko05014 Amyotrophic lateral sclerosis (ALS) 5/131 74/7206 0.010888183467 ko00510 N-Glycan biosynthesis 4/131 50/7206 0.0125996835267 ko04921 Oxytocin signaling pathway 9/131 209/7206 0.0136566514125 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 3/131 28/7206 0.013803898413 ko04371 Apelin signaling pathway 8/131 177/7206 0.0150940502509 ko00514 Other types of O-glycan biosynthesis 3/131 30/7206 0.0166639387419 ko04320 Dorso-ventral axis formation 3/131 31/7206 0.0182089907351 ko04918 Thyroid hormone synthesis 5/131 86/7206 0.0198305172297 ko05166 HTLV-I infection 11/131 292/7206 0.0211755787878 ko04270 Vascular smooth muscle contraction 7/131 154/7206 0.0218606669229 ko00562 Inositol phosphate metabolism 5/131 89/7206 0.0226464684251 ko04750 Inflammatory mediator regulation of TRP channels 6/131 122/7206 0.0234214156182 ko04913 Ovarian steroidogenesis 4/131 63/7206 0.0272341700522 ko04611 Platelet activation 7/131 163/7206 0.0287099676504 ko00564 Glycerophospholipid metabolism 5/131 99/7206 0.0338577490722 ko00513 Various types of N-glycan biosynthesis 3/131 42/7206 0.0402894526738 ko04973 Carbohydrate digestion and absorption 3/131 42/7206 0.0402894526738 ko04114 Oocyte meiosis 6/131 139/7206 0.0406696677774 ko04916 Melanogenesis 6/131 142/7206 0.0443728927499 ko04012 ErbB signaling pathway 5/131 109/7206 0.0480169690703 ko04010 MAPK signaling pathway 11/131 321/7206 0.0488945470263