ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 41/312 191/7206 2.9095609155e-18 ko05340 Primary immunodeficiency 14/312 30/7206 4.74331506379e-12 ko04380 Osteoclast differentiation 27/312 134/7206 1.13475037728e-11 ko05152 Tuberculosis 32/312 187/7206 1.32255442372e-11 ko05164 Influenza A 30/312 167/7206 1.68594659083e-11 ko05162 Measles 25/312 120/7206 3.15630717446e-11 ko04650 Natural killer cell mediated cytotoxicity 22/312 97/7206 8.70143321538e-11 ko05145 Toxoplasmosis 25/312 126/7206 9.68133800738e-11 ko05168 Herpes simplex infection 30/312 182/7206 1.57422271475e-10 ko05140 Leishmaniasis 19/312 75/7206 2.27272665871e-10 ko04612 Antigen processing and presentation 19/312 77/7206 3.71707978989e-10 ko04621 NOD-like receptor signaling pathway 27/312 157/7206 5.12049901889e-10 ko05320 Autoimmune thyroid disease 12/312 29/7206 9.42061412135e-10 ko05330 Allograft rejection 11/312 24/7206 1.26958234408e-09 ko04217 Necroptosis 28/312 178/7206 2.00618917009e-09 ko04659 Th17 cell differentiation 21/312 106/7206 3.33091988823e-09 ko05321 Inflammatory bowel disease (IBD) 15/312 56/7206 8.18623422723e-09 ko05332 Graft-versus-host disease 9/312 18/7206 1.64341338106e-08 ko04064 NF-kappa B signaling pathway 19/312 96/7206 1.93914951103e-08 ko04145 Phagosome 24/312 162/7206 9.82180988857e-08 ko04062 Chemokine signaling pathway 27/312 201/7206 1.22727327273e-07 ko04630 Jak-STAT signaling pathway 21/312 132/7206 1.85668955001e-07 ko04620 Toll-like receptor signaling pathway 18/312 100/7206 2.12494004283e-07 ko04672 Intestinal immune network for IgA production 11/312 37/7206 2.6199777003e-07 ko04658 Th1 and Th2 cell differentiation 17/312 96/7206 5.933538324e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/312 191/7206 2.15730578545e-06 ko04640 Hematopoietic cell lineage 13/312 64/7206 2.61445356466e-06 ko05310 Asthma 7/312 17/7206 3.56652457175e-06 ko04940 Type I diabetes mellitus 9/312 32/7206 5.53443945421e-06 ko05150 Staphylococcus aureus infection 9/312 36/7206 1.59351250665e-05 ko04660 T cell receptor signaling pathway 17/312 124/7206 2.17856857448e-05 ko04622 RIG-I-like receptor signaling pathway 11/312 62/7206 5.90086997701e-05 ko04662 B cell receptor signaling pathway 13/312 88/7206 9.35436398592e-05 ko05161 Hepatitis B 19/312 173/7206 0.000161972948294 ko04623 Cytosolic DNA-sensing pathway 8/312 41/7206 0.000308662064002 ko05160 Hepatitis C 17/312 153/7206 0.000310698670101 ko05133 Pertussis 12/312 87/7206 0.000335579163837 ko05323 Rheumatoid arthritis 12/312 89/7206 0.000415630102064 ko03050 Proteasome 9/312 54/7206 0.000452749536859 ko05034 Alcoholism 1/312 238/7206 0.000507665925554 ko05416 Viral myocarditis 9/312 55/7206 0.000521128406882 ko05142 Chagas disease (American trypanosomiasis) 14/312 130/7206 0.00141479510904 ko04137 Mitophagy - animal 10/312 82/7206 0.0026869505161 ko05144 Malaria 7/312 45/7206 0.00293015790139 ko04142 Lysosome 15/312 151/7206 0.00334878928269 ko04514 Cell adhesion molecules (CAMs) 13/312 130/7206 0.00399086717621 ko04310 Wnt signaling pathway 1/312 181/7206 0.00490161136251 ko04611 Platelet activation 15/312 163/7206 0.00523013949562 ko04390 Hippo signaling pathway 1/312 188/7206 0.00523799714146 ko04664 Fc epsilon RI signaling pathway 9/312 77/7206 0.00575129379349 ko04666 Fc gamma R-mediated phagocytosis 12/312 122/7206 0.00636579125362 ko00590 Arachidonic acid metabolism 7/312 52/7206 0.00667425053079 ko04080 Neuroactive ligand-receptor interaction 8/312 423/7206 0.00909266818251 ko00120 Primary bile acid biosynthesis 4/312 20/7206 0.00963460967004 ko05146 Amoebiasis 10/312 99/7206 0.0102655285331 ko05166 HTLV-I infection 22/312 292/7206 0.0114516606524 ko04360 Axon guidance 3/312 233/7206 0.0136300977998 ko04210 Apoptosis 15/312 180/7206 0.0140501511373 ko04670 Leukocyte transendothelial migration 13/312 151/7206 0.0147732170085 ko04724 Glutamatergic synapse 1/312 152/7206 0.014929337486 ko04668 TNF signaling pathway 11/312 120/7206 0.0192729871165 ko04610 Complement and coagulation cascades 8/312 79/7206 0.0203980117347 ko03040 Spliceosome 1/312 145/7206 0.0216501591101 ko05169 Epstein-Barr virus infection 16/312 206/7206 0.0220464325348 ko00511 Other glycan degradation 4/312 26/7206 0.0242648902804 ko05016 Huntington's disease 3/312 215/7206 0.0260649318252 ko04713 Circadian entrainment 1/312 136/7206 0.031238510735 ko04020 Calcium signaling pathway 5/312 265/7206 0.0446584887435 ko00190 Oxidative phosphorylation 1/312 127/7206 0.0449772856312 ko01200 Carbon metabolism 1/312 128/7206 0.0452347774287 ko04152 AMPK signaling pathway 2/312 161/7206 0.0487517405614