ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1205	423/7206	2.06906296404e-53
ko04724	Glutamatergic synapse	90/1205	152/7206	5.68687227398e-33
ko05033	Nicotine addiction	48/1205	56/7206	8.46452802034e-30
ko05032	Morphine addiction	68/1205	110/7206	1.05233839963e-26
ko04727	GABAergic synapse	66/1205	110/7206	7.01506518702e-25
ko04713	Circadian entrainment	74/1205	136/7206	4.38424127625e-24
ko04721	Synaptic vesicle cycle	52/1205	80/7206	3.76084091643e-22
ko04728	Dopaminergic synapse	86/1205	185/7206	1.07961922978e-21
ko04725	Cholinergic synapse	74/1205	160/7206	1.19695397962e-18
ko04024	cAMP signaling pathway	106/1205	279/7206	3.5423158547e-18
ko04723	Retrograde endocannabinoid signaling	77/1205	175/7206	8.70775898175e-18
ko04020	Calcium signaling pathway	100/1205	265/7206	5.58698269906e-17
ko04742	Taste transduction	38/1205	61/7206	1.32020605097e-15
ko04744	Phototransduction	27/1205	36/7206	1.67305996604e-14
ko04726	Serotonergic synapse	60/1205	137/7206	5.24986804125e-14
ko04921	Oxytocin signaling pathway	79/1205	209/7206	1.09759814021e-13
ko04911	Insulin secretion	53/1205	117/7206	3.06048811295e-13
ko05031	Amphetamine addiction	43/1205	91/7206	9.59860881166e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1205	205/7206	1.26982125982e-11
ko04720	Long-term potentiation	44/1205	99/7206	7.13251055334e-11
ko03040	Spliceosome	1/1205	145/7206	1.17091544508e-10
ko05203	Viral carcinogenesis	14/1205	277/7206	3.11688123298e-09
ko04970	Salivary secretion	40/1205	95/7206	3.69854810197e-09
ko05168	Herpes simplex infection	7/1205	182/7206	9.23503033754e-08
ko04022	cGMP-PKG signaling pathway	67/1205	216/7206	1.35516610281e-07
ko05030	Cocaine addiction	31/1205	73/7206	1.68499501531e-07
ko05322	Systemic lupus erythematosus	5/1205	151/7206	3.83299895471e-07
ko04925	Aldosterone synthesis and secretion	39/1205	105/7206	4.20701205242e-07
ko04060	Cytokine-cytokine receptor interaction	9/1205	191/7206	5.66025962497e-07
ko04360	Axon guidance	69/1205	233/7206	6.51817996393e-07
ko03013	RNA transport	7/1205	166/7206	8.54913732588e-07
ko04924	Renin secretion	33/1205	86/7206	1.26994116822e-06
ko04971	Gastric acid secretion	36/1205	98/7206	1.58167361142e-06
ko04740	Olfactory transduction	31/1205	80/7206	2.27539530017e-06
ko04070	Phosphatidylinositol signaling system	39/1205	112/7206	2.5203147118e-06
ko04966	Collecting duct acid secretion	15/1205	26/7206	2.52987521895e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1205	74/7206	4.28993180395e-06
ko05164	Influenza A	8/1205	167/7206	4.37714882761e-06
ko04010	MAPK signaling pathway	84/1205	321/7206	1.12936172971e-05
ko05169	Epstein-Barr virus infection	14/1205	206/7206	2.67304913071e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1205	79/7206	4.92098225106e-05
ko04621	NOD-like receptor signaling pathway	9/1205	157/7206	5.05625666322e-05
ko04141	Protein processing in endoplasmic reticulum	12/1205	184/7206	5.20283490623e-05
ko04972	Pancreatic secretion	35/1205	111/7206	9.62532940808e-05
ko04610	Complement and coagulation cascades	2/1205	79/7206	0.000110781638823
ko03008	Ribosome biogenesis in eukaryotes	2/1205	79/7206	0.000110781638823
ko05110	Vibrio cholerae infection	23/1205	63/7206	0.000126227838435
ko04072	Phospholipase D signaling pathway	54/1205	197/7206	0.000137351106318
ko05414	Dilated cardiomyopathy	35/1205	112/7206	0.000162319669978
ko04120	Ubiquitin mediated proteolysis	8/1205	138/7206	0.000187840251471
ko04514	Cell adhesion molecules (CAMs)	39/1205	130/7206	0.000188027155541
ko04745	Phototransduction - fly	16/1205	38/7206	0.000189803743658
ko04626	Plant-pathogen interaction	10/1205	18/7206	0.000197209291079
ko04976	Bile secretion	27/1205	80/7206	0.00020534504478
ko05205	Proteoglycans in cancer	24/1205	271/7206	0.000237069209577
ko05140	Leishmaniasis	2/1205	75/7206	0.000249449663235
ko04064	NF-kappa B signaling pathway	4/1205	96/7206	0.000271303459829
ko04730	Long-term depression	26/1205	78/7206	0.000323604356451
ko04964	Proximal tubule bicarbonate reclamation	13/1205	29/7206	0.000361772492606
ko04260	Cardiac muscle contraction	30/1205	98/7206	0.000559497473195
ko05161	Hepatitis B	13/1205	173/7206	0.00059137146252
ko04923	Regulation of lipolysis in adipocytes	25/1205	77/7206	0.00059359923114
ko04110	Cell cycle	10/1205	145/7206	0.000667139684359
ko04014	Ras signaling pathway	68/1205	279/7206	0.000999159228741
ko04612	Antigen processing and presentation	3/1205	77/7206	0.00102301857225
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1205	59/7206	0.00121823458215
ko05162	Measles	8/1205	120/7206	0.00182355960528
ko00240	Pyrimidine metabolism	7/1205	110/7206	0.00182906648415
ko04915	Estrogen signaling pathway	36/1205	131/7206	0.00190571599849
ko04750	Inflammatory mediator regulation of TRP channels	34/1205	122/7206	0.00197533728458
ko04146	Peroxisome	5/1205	89/7206	0.0024890237644
ko04540	Gap junction	35/1205	128/7206	0.00253273084519
ko04371	Apelin signaling pathway	45/1205	177/7206	0.00291905617243
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1205	14/7206	0.00415043958664
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1205	100/7206	0.0042312742787
ko05144	Malaria	1/1205	45/7206	0.00433378643529
ko00071	Fatty acid degradation	1/1205	45/7206	0.00433378643529
ko03420	Nucleotide excision repair	1/1205	46/7206	0.0044560931938
ko00480	Glutathione metabolism	2/1205	55/7206	0.00564567024914
ko05321	Inflammatory bowel disease (IBD)	2/1205	56/7206	0.00588814987406
ko04630	Jak-STAT signaling pathway	11/1205	132/7206	0.00663216592129
ko00310	Lysine degradation	4/1205	73/7206	0.00674436681758
ko05131	Shigellosis	5/1205	82/7206	0.00683790421613
ko03022	Basal transcription factors	1/1205	44/7206	0.00687337042412
ko00590	Arachidonic acid metabolism	2/1205	52/7206	0.00818247748414
ko04330	Notch signaling pathway	3/1205	62/7206	0.00925772286975
ko04622	RIG-I-like receptor signaling pathway	3/1205	62/7206	0.00925772286975
ko04510	Focal adhesion	26/1205	240/7206	0.0107244141291
ko04657	IL-17 signaling pathway	6/1205	87/7206	0.0129877492779
ko05133	Pertussis	6/1205	87/7206	0.0129877492779
ko00562	Inositol phosphate metabolism	24/1205	89/7206	0.0142220908913
ko04210	Apoptosis	18/1205	180/7206	0.014705795521
ko00630	Glyoxylate and dicarboxylate metabolism	1/1205	38/7206	0.0147645201723
ko05145	Toxoplasmosis	11/1205	126/7206	0.0152898352433
ko04922	Glucagon signaling pathway	32/1205	128/7206	0.0162030892107
ko05166	HTLV-I infection	34/1205	292/7206	0.0162127767544
ko00290	Valine, leucine and isoleucine biosynthesis	3/1205	4/7206	0.0163293061406
ko03018	RNA degradation	6/1205	84/7206	0.0174993494455
ko04115	p53 signaling pathway	5/1205	74/7206	0.0180805822481
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1205	182/7206	0.0203451937271
ko00500	Starch and sucrose metabolism	1/1205	35/7206	0.0219167054622
ko04214	Apoptosis - fly	5/1205	72/7206	0.0249995902125
ko04658	Th1 and Th2 cell differentiation	8/1205	96/7206	0.0266474352376
ko04640	Hematopoietic cell lineage	4/1205	64/7206	0.0267711046969
ko05215	Prostate cancer	10/1205	111/7206	0.0285159263278
ko04114	Oocyte meiosis	33/1205	139/7206	0.0291300756762
ko00330	Arginine and proline metabolism	4/1205	61/7206	0.0365699535905
ko05418	Fluid shear stress and atherosclerosis	19/1205	173/7206	0.039183797317
ko04918	Thyroid hormone synthesis	22/1205	86/7206	0.0401436248922
ko05132	Salmonella infection	9/1205	98/7206	0.0412478982248
ko04930	Type II diabetes mellitus	15/1205	54/7206	0.0415786276845
ko04620	Toll-like receptor signaling pathway	9/1205	100/7206	0.0416914428078
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1205	135/7206	0.047349470743
ko05340	Primary immunodeficiency	1/1205	30/7206	0.0486873608271
ko04912	GnRH signaling pathway	29/1205	122/7206	0.0490277204784
ko04270	Vascular smooth muscle contraction	35/1205	154/7206	0.0491388129005