ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 41/476 145/7206 3.09337391714e-16 ko04080 Neuroactive ligand-receptor interaction 1/476 423/7206 5.62301096943e-12 ko05217 Basal cell carcinoma 23/476 68/7206 2.10937923328e-11 ko04550 Signaling pathways regulating pluripotency of stem cells 36/476 165/7206 9.21721258846e-11 ko03030 DNA replication 16/476 38/7206 5.88264006591e-10 ko04110 Cell cycle 30/476 145/7206 1.33630010432e-08 ko04310 Wnt signaling pathway 32/476 181/7206 2.1870376746e-07 ko05224 Breast cancer 31/476 174/7206 2.84548683333e-07 ko03410 Base excision repair 13/476 38/7206 4.55006947348e-07 ko04390 Hippo signaling pathway 32/476 188/7206 5.34055813459e-07 ko04330 Notch signaling pathway 16/476 62/7206 1.63883481099e-06 ko04950 Maturity onset diabetes of the young 10/476 29/7206 9.19363778315e-06 ko05202 Transcriptional misregulation in cancer 29/476 188/7206 1.58849753678e-05 ko04111 Cell cycle - yeast 18/476 90/7206 1.83463685319e-05 ko04340 Hedgehog signaling pathway 13/476 58/7206 7.81422435837e-05 ko03015 mRNA surveillance pathway 17/476 93/7206 0.000103155460239 ko05205 Proteoglycans in cancer 35/476 271/7206 0.000138489465246 ko05418 Fluid shear stress and atherosclerosis 24/476 173/7206 0.000484474078977 ko04218 Cellular senescence 24/476 177/7206 0.000626415520053 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/476 182/7206 0.000693850263734 ko04724 Glutamatergic synapse 1/476 152/7206 0.000709881408404 ko04144 Endocytosis 9/476 342/7206 0.00112478716108 ko05200 Pathways in cancer 51/476 492/7206 0.00128002790489 ko05169 Epstein-Barr virus infection 26/476 206/7206 0.00143280520807 ko04013 MAPK signaling pathway - fly 17/476 115/7206 0.00171304096687 ko04060 Cytokine-cytokine receptor interaction 3/476 191/7206 0.00171761189591 ko05206 MicroRNAs in cancer 23/476 177/7206 0.00176842219447 ko04113 Meiosis - yeast 12/476 70/7206 0.00189372685171 ko03013 RNA transport 22/476 166/7206 0.00215511089276 ko04020 Calcium signaling pathway 6/476 265/7206 0.00219482664607 ko04120 Ubiquitin mediated proteolysis 19/476 138/7206 0.00251629493111 ko05012 Parkinson's disease 2/476 155/7206 0.00289674340282 ko05010 Alzheimer's disease 4/476 202/7206 0.00373727456819 ko04612 Antigen processing and presentation 12/476 77/7206 0.00429877098093 ko04723 Retrograde endocannabinoid signaling 3/476 175/7206 0.00488441283434 ko05166 HTLV-I infection 32/476 292/7206 0.00519960399503 ko05414 Dilated cardiomyopathy 1/476 112/7206 0.00668901940439 ko04360 Axon guidance 26/476 233/7206 0.0071213028839 ko05222 Small cell lung cancer 13/476 89/7206 0.00753098057643 ko04391 Hippo signaling pathway - fly 13/476 90/7206 0.00792117686416 ko04712 Circadian rhythm - plant 3/476 7/7206 0.00820284932306 ko04726 Serotonergic synapse 2/476 137/7206 0.00841627833856 ko04916 Melanogenesis 18/476 142/7206 0.00903091224726 ko04725 Cholinergic synapse 3/476 160/7206 0.00938887265799 ko04139 Mitophagy - yeast 7/476 37/7206 0.00955209528742 ko03420 Nucleotide excision repair 8/476 46/7206 0.00962439490191 ko03430 Mismatch repair 5/476 22/7206 0.0126846542334 ko04062 Chemokine signaling pathway 5/476 201/7206 0.0134981656494 ko04212 Longevity regulating pathway - worm 12/476 87/7206 0.0139447848134 ko04114 Oocyte meiosis 17/476 139/7206 0.0139544413133 ko04624 Toll and Imd signaling pathway 8/476 49/7206 0.0139951447574 ko05410 Hypertrophic cardiomyopathy (HCM) 1/476 100/7206 0.0141347289964 ko05168 Herpes simplex infection 21/476 182/7206 0.0141995796522 ko05130 Pathogenic Escherichia coli infection 11/476 77/7206 0.016793795573 ko04072 Phospholipase D signaling pathway 5/476 197/7206 0.0186011585798 ko04260 Cardiac muscle contraction 1/476 98/7206 0.021346475639 ko04011 MAPK signaling pathway - yeast 8/476 53/7206 0.0218660505919 ko03050 Proteasome 8/476 54/7206 0.0242418970155 ko04350 TGF-beta signaling pathway 13/476 103/7206 0.0245576608292 ko04662 B cell receptor signaling pathway 1/476 88/7206 0.0296581044791 ko04920 Adipocytokine signaling pathway 1/476 89/7206 0.0297784143468 ko04070 Phosphatidylinositol signaling system 2/476 112/7206 0.033528853212 ko04341 Hedgehog signaling pathway - fly 6/476 38/7206 0.0366124751526 ko04016 MAPK signaling pathway - plant 4/476 20/7206 0.0391111977233 ko05230 Central carbon metabolism in cancer 1/476 81/7206 0.0428140516667 ko04138 Autophagy - yeast 1/476 81/7206 0.0428140516667 ko01522 Endocrine resistance 14/476 124/7206 0.0431441113504 ko01200 Carbon metabolism 3/476 128/7206 0.047387995037 ko04630 Jak-STAT signaling pathway 3/476 132/7206 0.0486852852462