ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 23/455 112/7206 3.52197098901e-07 ko04744 Phototransduction 12/455 36/7206 1.08041668263e-06 ko04710 Circadian rhythm 13/455 43/7206 1.36069038425e-06 ko04721 Synaptic vesicle cycle 17/455 80/7206 7.43952548755e-06 ko04966 Collecting duct acid secretion 9/455 26/7206 1.75095934026e-05 ko04724 Glutamatergic synapse 24/455 152/7206 2.47846239576e-05 ko04650 Natural killer cell mediated cytotoxicity 17/455 97/7206 0.000101958312875 ko04921 Oxytocin signaling pathway 28/455 209/7206 0.00012870125046 ko05032 Morphine addiction 18/455 110/7206 0.000160322455188 ko00010 Glycolysis / Gluconeogenesis 14/455 74/7206 0.00017952119232 ko04713 Circadian entrainment 20/455 136/7206 0.000442649489794 ko04725 Cholinergic synapse 22/455 160/7206 0.000448034171191 ko05110 Vibrio cholerae infection 12/455 63/7206 0.000482781763332 ko05031 Amphetamine addiction 15/455 91/7206 0.000513796081146 ko00051 Fructose and mannose metabolism 9/455 42/7206 0.00101022754634 ko04726 Serotonergic synapse 19/455 137/7206 0.00104343973813 ko00564 Glycerophospholipid metabolism 15/455 99/7206 0.00126713059799 ko04720 Long-term potentiation 15/455 99/7206 0.00126713059799 ko04922 Glucagon signaling pathway 18/455 128/7206 0.00127959151685 ko03040 Spliceosome 1/455 145/7206 0.00150971554641 ko04110 Cell cycle 1/455 145/7206 0.00150971554641 ko04728 Dopaminergic synapse 23/455 185/7206 0.0017762424519 ko04745 Phototransduction - fly 8/455 38/7206 0.00215957015369 ko04911 Insulin secretion 16/455 117/7206 0.00310254632528 ko04925 Aldosterone synthesis and secretion 15/455 105/7206 0.00332015552435 ko05323 Rheumatoid arthritis 13/455 89/7206 0.00364132516123 ko04145 Phagosome 20/455 162/7206 0.00457073675119 ko00680 Methane metabolism 7/455 34/7206 0.00462638860648 ko03010 Ribosome 1/455 129/7206 0.00496391586057 ko00592 alpha-Linolenic acid metabolism 5/455 19/7206 0.00544824360038 ko04020 Calcium signaling pathway 28/455 265/7206 0.00647876779427 ko05224 Breast cancer 3/455 174/7206 0.00677813828168 ko04711 Circadian rhythm - fly 4/455 13/7206 0.00709698890296 ko03013 RNA transport 3/455 166/7206 0.00945491970534 ko04727 GABAergic synapse 14/455 110/7206 0.00974999604372 ko00562 Inositol phosphate metabolism 12/455 89/7206 0.0126071606927 ko00030 Pentose phosphate pathway 6/455 32/7206 0.0136345417001 ko04060 Cytokine-cytokine receptor interaction 21/455 191/7206 0.0144354088938 ko05120 Epithelial cell signaling in Helicobacter pylori infection 12/455 92/7206 0.0148906666584 ko04014 Ras signaling pathway 28/455 279/7206 0.0160879052881 ko01040 Biosynthesis of unsaturated fatty acids 5/455 25/7206 0.0182182331964 ko05200 Pathways in cancer 19/455 492/7206 0.0206436629598 ko04662 B cell receptor signaling pathway 11/455 88/7206 0.0250920010784 ko04380 Osteoclast differentiation 15/455 134/7206 0.0290339696751 ko03015 mRNA surveillance pathway 1/455 93/7206 0.0299650146142 ko04740 Olfactory transduction 10/455 80/7206 0.0334907163209 ko05230 Central carbon metabolism in cancer 10/455 81/7206 0.0353917492452 ko04138 Autophagy - yeast 10/455 81/7206 0.0353917492452 ko04666 Fc gamma R-mediated phagocytosis 14/455 122/7206 0.0355278905476 ko04960 Aldosterone-regulated sodium reabsorption 6/455 41/7206 0.0420651172741 ko04630 Jak-STAT signaling pathway 14/455 132/7206 0.0468704082376 ko04611 Platelet activation 17/455 163/7206 0.0478609445341