ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 27/215 152/7206 3.22132325039e-14 ko04713 Circadian entrainment 20/215 136/7206 2.70931584714e-09 ko04020 Calcium signaling pathway 27/215 265/7206 1.66010807939e-08 ko05030 Cocaine addiction 14/215 73/7206 2.26313695166e-08 ko04728 Dopaminergic synapse 22/215 185/7206 2.41683305948e-08 ko05031 Amphetamine addiction 15/215 91/7206 5.98310925108e-08 ko04080 Neuroactive ligand-receptor interaction 33/215 423/7206 2.70684697451e-07 ko04915 Estrogen signaling pathway 17/215 131/7206 2.88726612354e-07 ko05032 Morphine addiction 15/215 110/7206 7.7625622062e-07 ko04720 Long-term potentiation 14/215 99/7206 1.17028031118e-06 ko04925 Aldosterone synthesis and secretion 14/215 105/7206 2.41147403661e-06 ko04723 Retrograde endocannabinoid signaling 18/215 175/7206 4.09182886174e-06 ko04727 GABAergic synapse 14/215 110/7206 4.2314313999e-06 ko05033 Nicotine addiction 10/215 56/7206 4.85876495597e-06 ko04725 Cholinergic synapse 17/215 160/7206 4.92269320829e-06 ko04911 Insulin secretion 14/215 117/7206 8.80464625685e-06 ko04211 Longevity regulating pathway 14/215 123/7206 1.57704283523e-05 ko04022 cGMP-PKG signaling pathway 19/215 216/7206 2.15149554668e-05 ko04024 cAMP signaling pathway 22/215 279/7206 2.66721658242e-05 ko04912 GnRH signaling pathway 13/215 122/7206 6.41941090711e-05 ko04072 Phospholipase D signaling pathway 17/215 197/7206 7.53099369408e-05 ko04261 Adrenergic signaling in cardiomyocytes 17/215 205/7206 0.000123369470984 ko04360 Axon guidance 18/215 233/7206 0.000191984647738 ko04726 Serotonergic synapse 13/215 137/7206 0.000210582176007 ko04012 ErbB signaling pathway 11/215 109/7206 0.000380599530313 ko04540 Gap junction 12/215 128/7206 0.000412251966425 ko04742 Taste transduction 8/215 61/7206 0.000415973944308 ko04923 Regulation of lipolysis in adipocytes 9/215 77/7206 0.000439109274761 ko04010 MAPK signaling pathway 21/215 321/7206 0.000607970306573 ko05231 Choline metabolism in cancer 12/215 134/7206 0.000625734086391 ko04371 Apelin signaling pathway 14/215 177/7206 0.000789853677063 ko04062 Chemokine signaling pathway 15/215 201/7206 0.000944450976811 ko04213 Longevity regulating pathway - multiple species 9/215 86/7206 0.000992885418278 ko04918 Thyroid hormone synthesis 9/215 86/7206 0.000992885418278 ko04914 Progesterone-mediated oocyte maturation 10/215 104/7206 0.00102271973907 ko01521 EGFR tyrosine kinase inhibitor resistance 10/215 106/7206 0.00118518004654 ko04921 Oxytocin signaling pathway 15/215 209/7206 0.00140300622365 ko04970 Salivary secretion 9/215 95/7206 0.00201347213535 ko04270 Vascular smooth muscle contraction 12/215 154/7206 0.00210827063064 ko04730 Long-term depression 8/215 78/7206 0.00214746894743 ko05213 Endometrial cancer 7/215 62/7206 0.00232944007632 ko04971 Gastric acid secretion 9/215 98/7206 0.00249701965967 ko04916 Melanogenesis 11/215 142/7206 0.00335243598603 ko04611 Platelet activation 12/215 163/7206 0.0033797756388 ko04666 Fc gamma R-mediated phagocytosis 10/215 122/7206 0.00339251283964 ko04144 Endocytosis 20/215 342/7206 0.00471540600055 ko04015 Rap1 signaling pathway 17/215 278/7206 0.00566075297644 ko04972 Pancreatic secretion 9/215 111/7206 0.0057498912744 ko00515 Mannose type O-glycan biosynthesis 4/215 25/7206 0.00595602381782 ko04070 Phosphatidylinositol signaling system 9/215 112/7206 0.00609474998049 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/215 26/7206 0.00687722602471 ko04740 Olfactory transduction 7/215 80/7206 0.00959229058784 ko00512 Mucin type O-glycan biosynthesis 4/215 29/7206 0.0101914479859 ko01522 Endocrine resistance 9/215 124/7206 0.0115943602234 ko04320 Dorso-ventral axis formation 4/215 31/7206 0.0128910911189 ko05223 Non-small cell lung cancer 6/215 66/7206 0.0134844021963 ko04917 Prolactin signaling pathway 7/215 87/7206 0.0148258585467 ko05034 Alcoholism 14/215 238/7206 0.0171882321144 ko05414 Dilated cardiomyopathy 8/215 112/7206 0.0184527636372 ko05166 HTLV-I infection 16/215 292/7206 0.0200498351175 ko04011 MAPK signaling pathway - yeast 5/215 53/7206 0.020275144137 ko04930 Type II diabetes mellitus 5/215 54/7206 0.0218190742884 ko04014 Ras signaling pathway 15/215 279/7206 0.0283588474317 ko04750 Inflammatory mediator regulation of TRP channels 8/215 122/7206 0.0290935376008 ko05214 Glioma 6/215 79/7206 0.0300658692288 ko04660 T cell receptor signaling pathway 8/215 124/7206 0.0316436536217 ko04973 Carbohydrate digestion and absorption 4/215 42/7206 0.0356196360779 ko04910 Insulin signaling pathway 10/215 172/7206 0.0378634595708 ko04913 Ovarian steroidogenesis 5/215 63/7206 0.0391883779068 ko05224 Breast cancer 10/215 174/7206 0.0398564235881 ko05210 Colorectal cancer 6/215 86/7206 0.0429392604856 ko04924 Renin secretion 6/215 86/7206 0.0429392604856 ko00562 Inositol phosphate metabolism 6/215 89/7206 0.0493733417795