ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1123	423/7206	2.3291771012e-57
ko04724	Glutamatergic synapse	87/1123	152/7206	9.54232177816e-33
ko05033	Nicotine addiction	47/1123	56/7206	9.00755782302e-30
ko05032	Morphine addiction	67/1123	110/7206	1.2041092437e-27
ko04727	GABAergic synapse	65/1123	110/7206	8.85911920201e-26
ko04713	Circadian entrainment	71/1123	136/7206	1.3051452693e-23
ko04728	Dopaminergic synapse	84/1123	185/7206	1.8356251071e-22
ko04721	Synaptic vesicle cycle	48/1123	80/7206	1.00332653907e-19
ko04725	Cholinergic synapse	72/1123	160/7206	4.04257284297e-19
ko04723	Retrograde endocannabinoid signaling	76/1123	175/7206	5.30236390791e-19
ko04024	cAMP signaling pathway	101/1123	279/7206	7.17655661248e-18
ko04020	Calcium signaling pathway	96/1123	265/7206	5.43283186175e-17
ko04742	Taste transduction	38/1123	61/7206	1.1746272609e-16
ko04726	Serotonergic synapse	60/1123	137/7206	1.90904933948e-15
ko04911	Insulin secretion	53/1123	117/7206	1.56651348474e-14
ko04744	Phototransduction	25/1123	36/7206	5.46962430633e-13
ko04921	Oxytocin signaling pathway	74/1123	209/7206	9.00970026692e-13
ko05031	Amphetamine addiction	41/1123	91/7206	1.93571539486e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1123	205/7206	2.62137278089e-11
ko04360	Axon guidance	76/1123	233/7206	4.21433010948e-11
ko04720	Long-term potentiation	41/1123	99/7206	4.82280780435e-10
ko03040	Spliceosome	1/1123	145/7206	8.36303727814e-10
ko04970	Salivary secretion	38/1123	95/7206	6.72054081595e-09
ko05203	Viral carcinogenesis	13/1123	277/7206	1.43513397733e-08
ko04740	Olfactory transduction	32/1123	80/7206	1.05086024433e-07
ko05168	Herpes simplex infection	6/1123	182/7206	1.2531275503e-07
ko05030	Cocaine addiction	30/1123	73/7206	1.28785847004e-07
ko05322	Systemic lupus erythematosus	4/1123	151/7206	3.21059747084e-07
ko05164	Influenza A	6/1123	167/7206	1.23285377979e-06
ko04925	Aldosterone synthesis and secretion	36/1123	105/7206	1.85396505123e-06
ko04010	MAPK signaling pathway	82/1123	321/7206	2.71960031829e-06
ko04971	Gastric acid secretion	34/1123	98/7206	3.23111854478e-06
ko04022	cGMP-PKG signaling pathway	60/1123	216/7206	3.54368503174e-06
ko04060	Cytokine-cytokine receptor interaction	9/1123	191/7206	3.76883978469e-06
ko03013	RNA transport	7/1123	166/7206	6.19319788682e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1123	74/7206	1.16114954207e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1123	79/7206	1.21296236799e-05
ko04514	Cell adhesion molecules (CAMs)	40/1123	130/7206	1.24699755672e-05
ko04924	Renin secretion	29/1123	86/7206	2.97459580994e-05
ko04120	Ubiquitin mediated proteolysis	6/1123	138/7206	4.47659620615e-05
ko04260	Cardiac muscle contraction	31/1123	98/7206	5.91138762859e-05
ko04750	Inflammatory mediator regulation of TRP channels	36/1123	122/7206	7.72148911397e-05
ko04621	NOD-like receptor signaling pathway	8/1123	157/7206	7.73914551898e-05
ko04141	Protein processing in endoplasmic reticulum	11/1123	184/7206	7.91185458869e-05
ko04745	Phototransduction - fly	16/1123	38/7206	8.01829651968e-05
ko04540	Gap junction	37/1123	128/7206	0.000108908810499
ko04972	Pancreatic secretion	33/1123	111/7206	0.000164621551457
ko05169	Epstein-Barr virus infection	14/1123	206/7206	0.000184810150309
ko04014	Ras signaling pathway	67/1123	279/7206	0.000191188159473
ko04966	Collecting duct acid secretion	12/1123	26/7206	0.000222125287145
ko04730	Long-term depression	25/1123	78/7206	0.000230530139994
ko04610	Complement and coagulation cascades	2/1123	79/7206	0.000269189587133
ko03008	Ribosome biogenesis in eukaryotes	2/1123	79/7206	0.000269189587133
ko04612	Antigen processing and presentation	2/1123	77/7206	0.000397867140544
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1123	59/7206	0.000423531787502
ko05414	Dilated cardiomyopathy	32/1123	112/7206	0.000514531948902
ko04070	Phosphatidylinositol signaling system	32/1123	112/7206	0.000514531948902
ko05205	Proteoglycans in cancer	23/1123	271/7206	0.000600102303525
ko05161	Hepatitis B	12/1123	173/7206	0.000900282421416
ko05162	Measles	7/1123	120/7206	0.00141688851485
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1123	182/7206	0.00180451328627
ko04110	Cell cycle	10/1123	145/7206	0.00241323583002
ko04064	NF-kappa B signaling pathway	5/1123	96/7206	0.00265166413892
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1123	14/7206	0.00274079726008
ko05140	Leishmaniasis	3/1123	75/7206	0.00336359380993
ko04630	Jak-STAT signaling pathway	9/1123	132/7206	0.00339949666467
ko04072	Phospholipase D signaling pathway	46/1123	197/7206	0.00370022122466
ko05110	Vibrio cholerae infection	19/1123	63/7206	0.00432766647649
ko00240	Pyrimidine metabolism	7/1123	110/7206	0.00503071023891
ko05215	Prostate cancer	7/1123	111/7206	0.00511993738026
ko05144	Malaria	1/1123	45/7206	0.0068729620595
ko00071	Fatty acid degradation	1/1123	45/7206	0.0068729620595
ko00620	Pyruvate metabolism	1/1123	46/7206	0.00690940566349
ko03420	Nucleotide excision repair	1/1123	46/7206	0.00690940566349
ko04146	Peroxisome	5/1123	89/7206	0.00735260107646
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1123	100/7206	0.00759724956744
ko04371	Apelin signaling pathway	41/1123	177/7206	0.00829320481485
ko00480	Glutathione metabolism	2/1123	55/7206	0.00859133200543
ko03018	RNA degradation	5/1123	84/7206	0.0099414977474
ko01524	Platinum drug resistance	4/1123	76/7206	0.0100418413802
ko03022	Basal transcription factors	1/1123	44/7206	0.0105378512506
ko04976	Bile secretion	21/1123	80/7206	0.0124390627806
ko01200	Carbon metabolism	10/1123	128/7206	0.0132910068905
ko04330	Notch signaling pathway	3/1123	62/7206	0.0135674343204
ko04622	RIG-I-like receptor signaling pathway	3/1123	62/7206	0.0135674343204
ko05131	Shigellosis	5/1123	82/7206	0.0136929228664
ko04214	Apoptosis - fly	4/1123	72/7206	0.0138659818272
ko04640	Hematopoietic cell lineage	3/1123	64/7206	0.0139082463372
ko00310	Lysine degradation	4/1123	73/7206	0.013971556768
ko04626	Plant-pathogen interaction	7/1123	18/7206	0.0143868236474
ko04915	Estrogen signaling pathway	31/1123	131/7206	0.0144611815867
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1123	40/7206	0.0152966534165
ko00140	Steroid hormone biosynthesis	1/1123	41/7206	0.0155243833037
ko00983	Drug metabolism - other enzymes	1/1123	42/7206	0.016225758962
ko04620	Toll-like receptor signaling pathway	7/1123	100/7206	0.0172040282109
ko05145	Toxoplasmosis	10/1123	126/7206	0.0176917600772
ko00590	Arachidonic acid metabolism	2/1123	52/7206	0.0189947919672
ko05418	Fluid shear stress and atherosclerosis	16/1123	173/7206	0.0191350980689
ko00330	Arginine and proline metabolism	3/1123	61/7206	0.019540650793
ko04140	Autophagy - animal	15/1123	164/7206	0.0215916256952
ko04658	Th1 and Th2 cell differentiation	7/1123	96/7206	0.0225922175086
ko00982	Drug metabolism - cytochrome P450	1/1123	37/7206	0.0228136516501
ko00630	Glyoxylate and dicarboxylate metabolism	1/1123	38/7206	0.0229225519481
ko04657	IL-17 signaling pathway	6/1123	87/7206	0.024485792364
ko05133	Pertussis	6/1123	87/7206	0.024485792364
ko05219	Bladder cancer	2/1123	48/7206	0.0262630245578
ko04015	Rap1 signaling pathway	57/1123	278/7206	0.027885386431
ko04142	Lysosome	14/1123	151/7206	0.0306529561132
ko05220	Chronic myeloid leukemia	6/1123	85/7206	0.0335073692025
ko04964	Proximal tubule bicarbonate reclamation	9/1123	29/7206	0.0350499099638
ko04115	p53 signaling pathway	5/1123	74/7206	0.0351085155481
ko04210	Apoptosis	18/1123	180/7206	0.0369727752869
ko00280	Valine, leucine and isoleucine degradation	3/1123	54/7206	0.0380614103388
ko04923	Regulation of lipolysis in adipocytes	19/1123	77/7206	0.0381905771494
ko05222	Small cell lung cancer	7/1123	89/7206	0.0398811987859
ko04137	Mitophagy - animal	6/1123	82/7206	0.0446393299186