ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1111	423/7206	5.73683608874e-53
ko04724	Glutamatergic synapse	85/1111	152/7206	2.41527967453e-31
ko05033	Nicotine addiction	47/1111	56/7206	5.4725402131e-30
ko04713	Circadian entrainment	72/1111	136/7206	1.04296858121e-24
ko05032	Morphine addiction	63/1111	110/7206	3.05435267189e-24
ko04721	Synaptic vesicle cycle	52/1111	80/7206	7.65950835938e-24
ko04727	GABAergic synapse	61/1111	110/7206	1.70351431866e-22
ko04728	Dopaminergic synapse	80/1111	185/7206	4.15652545285e-20
ko04725	Cholinergic synapse	73/1111	160/7206	4.46740288749e-20
ko04723	Retrograde endocannabinoid signaling	72/1111	175/7206	9.19436505905e-17
ko04024	cAMP signaling pathway	97/1111	279/7206	3.30301717864e-16
ko04726	Serotonergic synapse	60/1111	137/7206	1.14263629514e-15
ko04742	Taste transduction	36/1111	61/7206	6.16747455328e-15
ko04020	Calcium signaling pathway	91/1111	265/7206	6.44977111046e-15
ko04911	Insulin secretion	51/1111	117/7206	2.09817166563e-13
ko04921	Oxytocin signaling pathway	73/1111	209/7206	1.56159120615e-12
ko04744	Phototransduction	24/1111	36/7206	5.01747133309e-12
ko04740	Olfactory transduction	38/1111	80/7206	1.05091790629e-11
ko04720	Long-term potentiation	42/1111	99/7206	8.31140653018e-11
ko05031	Amphetamine addiction	39/1111	91/7206	2.74322244123e-10
ko03040	Spliceosome	1/1111	145/7206	1.42330902641e-09
ko04261	Adrenergic signaling in cardiomyocytes	65/1111	205/7206	2.91971796478e-09
ko04970	Salivary secretion	38/1111	95/7206	4.94511216203e-09
ko05203	Viral carcinogenesis	14/1111	277/7206	6.11905483507e-08
ko05030	Cocaine addiction	30/1111	73/7206	1.00735265687e-07
ko04360	Axon guidance	66/1111	233/7206	4.14264637829e-07
ko05168	Herpes simplex infection	7/1111	182/7206	7.01869503012e-07
ko04060	Cytokine-cytokine receptor interaction	8/1111	191/7206	1.18881872094e-06
ko04925	Aldosterone synthesis and secretion	36/1111	105/7206	1.57768370682e-06
ko04971	Gastric acid secretion	34/1111	98/7206	1.76028140123e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1111	74/7206	1.97801159939e-06
ko05322	Systemic lupus erythematosus	5/1111	151/7206	2.04071568527e-06
ko04540	Gap junction	40/1111	128/7206	5.38115668931e-06
ko03013	RNA transport	7/1111	166/7206	6.10792645078e-06
ko04966	Collecting duct acid secretion	14/1111	26/7206	6.16187812677e-06
ko05164	Influenza A	7/1111	167/7206	6.1624848389e-06
ko04730	Long-term depression	28/1111	78/7206	8.52594463122e-06
ko04514	Cell adhesion molecules (CAMs)	40/1111	130/7206	1.12934531737e-05
ko04022	cGMP-PKG signaling pathway	58/1111	216/7206	1.28859892428e-05
ko04010	MAPK signaling pathway	77/1111	321/7206	3.61057291343e-05
ko04120	Ubiquitin mediated proteolysis	6/1111	138/7206	6.55541228561e-05
ko04745	Phototransduction - fly	16/1111	38/7206	7.01758949779e-05
ko04621	NOD-like receptor signaling pathway	8/1111	157/7206	7.56195541481e-05
ko05169	Epstein-Barr virus infection	13/1111	206/7206	7.76727598004e-05
ko04110	Cell cycle	7/1111	145/7206	0.000100908428668
ko04141	Protein processing in endoplasmic reticulum	11/1111	184/7206	0.00011044327539
ko05110	Vibrio cholerae infection	22/1111	63/7206	0.000126741827224
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1111	79/7206	0.000241015381571
ko04972	Pancreatic secretion	32/1111	111/7206	0.000279013688769
ko04260	Cardiac muscle contraction	29/1111	98/7206	0.000333859474428
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1111	59/7206	0.000377466149877
ko04612	Antigen processing and presentation	2/1111	77/7206	0.000404186448496
ko03008	Ribosome biogenesis in eukaryotes	2/1111	79/7206	0.000415539509175
ko04924	Renin secretion	26/1111	86/7206	0.000437552378193
ko04014	Ras signaling pathway	65/1111	279/7206	0.000483704219141
ko05162	Measles	6/1111	120/7206	0.000516394715848
ko05140	Leishmaniasis	2/1111	75/7206	0.000594365651049
ko05205	Proteoglycans in cancer	23/1111	271/7206	0.000779900315807
ko04064	NF-kappa B signaling pathway	4/1111	96/7206	0.000886925290906
ko04072	Phospholipase D signaling pathway	47/1111	197/7206	0.00178169416969
ko04146	Peroxisome	4/1111	89/7206	0.00178766952497
ko00480	Glutathione metabolism	1/1111	55/7206	0.00210381951843
ko04750	Inflammatory mediator regulation of TRP channels	32/1111	122/7206	0.00211909192194
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1111	182/7206	0.0024060658389
ko04610	Complement and coagulation cascades	3/1111	79/7206	0.0024116921852
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1111	14/7206	0.00257135956897
ko05161	Hepatitis B	13/1111	173/7206	0.00263790619399
ko00590	Arachidonic acid metabolism	1/1111	52/7206	0.00311959639002
ko04915	Estrogen signaling pathway	33/1111	131/7206	0.00316236343732
ko04626	Plant-pathogen interaction	8/1111	18/7206	0.00320723139899
ko05414	Dilated cardiomyopathy	29/1111	112/7206	0.0034902783983
ko04070	Phosphatidylinositol signaling system	29/1111	112/7206	0.0034902783983
ko05166	HTLV-I infection	28/1111	292/7206	0.00370864078533
ko04330	Notch signaling pathway	2/1111	62/7206	0.00408837003153
ko04976	Bile secretion	22/1111	80/7206	0.00472070753474
ko00310	Lysine degradation	3/1111	73/7206	0.00485119915979
ko05418	Fluid shear stress and atherosclerosis	14/1111	173/7206	0.00535211312699
ko04371	Apelin signaling pathway	41/1111	177/7206	0.00589490583193
ko03420	Nucleotide excision repair	1/1111	46/7206	0.00691550639626
ko04964	Proximal tubule bicarbonate reclamation	10/1111	29/7206	0.00887276215866
ko01524	Platinum drug resistance	4/1111	76/7206	0.0099975902641
ko04630	Jak-STAT signaling pathway	10/1111	132/7206	0.0101255497971
ko03022	Basal transcription factors	1/1111	44/7206	0.0104440020072
ko05144	Malaria	1/1111	45/7206	0.0108860892241
ko00071	Fatty acid degradation	1/1111	45/7206	0.0108860892241
ko00280	Valine, leucine and isoleucine degradation	2/1111	54/7206	0.0126481765215
ko04115	p53 signaling pathway	4/1111	74/7206	0.0141145800966
ko04668	TNF signaling pathway	9/1111	120/7206	0.014665899823
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1111	40/7206	0.0154358308271
ko00140	Steroid hormone biosynthesis	1/1111	41/7206	0.0154645288376
ko00240	Pyrimidine metabolism	8/1111	110/7206	0.0158382500578
ko05145	Toxoplasmosis	10/1111	126/7206	0.017440902936
ko00330	Arginine and proline metabolism	3/1111	61/7206	0.0194014424595
ko05131	Shigellosis	5/1111	82/7206	0.0195995552352
ko04622	RIG-I-like receptor signaling pathway	3/1111	62/7206	0.0198512640033
ko04214	Apoptosis - fly	4/1111	72/7206	0.0200351988505
ko04015	Rap1 signaling pathway	57/1111	278/7206	0.0218056471673
ko04658	Th1 and Th2 cell differentiation	7/1111	96/7206	0.0226374422191
ko00630	Glyoxylate and dicarboxylate metabolism	1/1111	38/7206	0.022927181126
ko04657	IL-17 signaling pathway	6/1111	87/7206	0.0243645081192
ko05133	Pertussis	6/1111	87/7206	0.0243645081192
ko00260	Glycine, serine and threonine metabolism	2/1111	48/7206	0.0262340011243
ko04350	TGF-beta signaling pathway	8/1111	103/7206	0.0275757191293
ko05034	Alcoholism	49/1111	238/7206	0.0283350459989
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1111	92/7206	0.0288209162384
ko04912	GnRH signaling pathway	28/1111	122/7206	0.0304294397955
ko03018	RNA degradation	6/1111	84/7206	0.0327577043983
ko00512	Mucin type O-glycan biosynthesis	9/1111	29/7206	0.0337645582506
ko00500	Starch and sucrose metabolism	1/1111	35/7206	0.0340078666047
ko00982	Drug metabolism - cytochrome P450	1/1111	37/7206	0.0358111520524
ko04620	Toll-like receptor signaling pathway	8/1111	100/7206	0.0362993346828
ko04923	Regulation of lipolysis in adipocytes	19/1111	77/7206	0.0371066703997
ko04640	Hematopoietic cell lineage	4/1111	64/7206	0.0371774840532
ko04930	Type II diabetes mellitus	14/1111	54/7206	0.0378201496205
ko05321	Inflammatory bowel disease (IBD)	3/1111	56/7206	0.0388006551183
ko04916	Melanogenesis	31/1111	142/7206	0.0448901991583
ko04978	Mineral absorption	11/1111	40/7206	0.0454712587426