ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1194	423/7206	1.40428634242e-55
ko04724	Glutamatergic synapse	89/1194	152/7206	2.08493759002e-32
ko05033	Nicotine addiction	49/1194	56/7206	1.69969943781e-31
ko04713	Circadian entrainment	77/1194	136/7206	8.23324912183e-27
ko04721	Synaptic vesicle cycle	55/1194	80/7206	2.06442860626e-25
ko04727	GABAergic synapse	66/1194	110/7206	4.07562197989e-25
ko05032	Morphine addiction	65/1194	110/7206	3.17730636513e-24
ko04728	Dopaminergic synapse	88/1194	185/7206	2.504011472e-23
ko04725	Cholinergic synapse	75/1194	160/7206	1.49385969087e-19
ko04742	Taste transduction	40/1194	61/7206	1.14551574687e-17
ko04024	cAMP signaling pathway	104/1194	279/7206	1.58766086213e-17
ko04911	Insulin secretion	59/1194	117/7206	1.61458793504e-17
ko04723	Retrograde endocannabinoid signaling	76/1194	175/7206	2.07802301439e-17
ko04020	Calcium signaling pathway	100/1194	265/7206	3.92514592888e-17
ko04744	Phototransduction	28/1194	36/7206	8.19032993401e-16
ko04740	Olfactory transduction	44/1194	80/7206	3.5158187925e-15
ko04726	Serotonergic synapse	60/1194	137/7206	3.42906875992e-14
ko04921	Oxytocin signaling pathway	79/1194	209/7206	7.67023869392e-14
ko04720	Long-term potentiation	47/1194	99/7206	5.84444058391e-13
ko05031	Amphetamine addiction	44/1194	91/7206	1.45643100507e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1194	205/7206	5.94088574344e-12
ko04970	Salivary secretion	43/1194	95/7206	4.1523351385e-11
ko03040	Spliceosome	1/1194	145/7206	2.00775160989e-10
ko05203	Viral carcinogenesis	13/1194	277/7206	9.82659981202e-10
ko04925	Aldosterone synthesis and secretion	42/1194	105/7206	1.19237001153e-08
ko05168	Herpes simplex infection	6/1194	182/7206	2.36769526032e-08
ko05030	Cocaine addiction	32/1194	73/7206	3.41526922758e-08
ko04971	Gastric acid secretion	39/1194	98/7206	4.65147105817e-08
ko04360	Axon guidance	70/1194	233/7206	2.13853751519e-07
ko04060	Cytokine-cytokine receptor interaction	9/1194	191/7206	5.63155827531e-07
ko03013	RNA transport	7/1194	166/7206	1.27619327825e-06
ko04540	Gap junction	43/1194	128/7206	1.79689764366e-06
ko04745	Phototransduction - fly	19/1194	38/7206	1.8851831948e-06
ko04966	Collecting duct acid secretion	15/1194	26/7206	2.24408963582e-06
ko04022	cGMP-PKG signaling pathway	63/1194	216/7206	2.55955813391e-06
ko04260	Cardiac muscle contraction	35/1194	98/7206	3.41879144678e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1194	74/7206	3.93475659973e-06
ko04120	Ubiquitin mediated proteolysis	5/1194	138/7206	4.01502022227e-06
ko05164	Influenza A	8/1194	167/7206	4.25662564664e-06
ko04141	Protein processing in endoplasmic reticulum	10/1194	184/7206	7.23169684624e-06
ko05322	Systemic lupus erythematosus	7/1194	151/7206	1.13022337153e-05
ko04010	MAPK signaling pathway	83/1194	321/7206	1.48971194295e-05
ko04621	NOD-like receptor signaling pathway	8/1194	157/7206	1.74069414827e-05
ko04610	Complement and coagulation cascades	1/1194	79/7206	2.10148659172e-05
ko04924	Renin secretion	30/1194	86/7206	2.88753037461e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1194	59/7206	3.0376170666e-05
ko05169	Epstein-Barr virus infection	14/1194	206/7206	3.69160235746e-05
ko04730	Long-term depression	28/1194	78/7206	3.75861694228e-05
ko05110	Vibrio cholerae infection	24/1194	63/7206	4.25979275244e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1194	79/7206	4.39519847928e-05
ko04976	Bile secretion	28/1194	80/7206	5.27944879585e-05
ko04972	Pancreatic secretion	35/1194	111/7206	8.50101144903e-05
ko05162	Measles	6/1194	120/7206	0.00016851055345
ko03008	Ribosome biogenesis in eukaryotes	2/1194	79/7206	0.000176709224213
ko05140	Leishmaniasis	2/1194	75/7206	0.000249064478927
ko04110	Cell cycle	9/1194	145/7206	0.0002647156625
ko04064	NF-kappa B signaling pathway	4/1194	96/7206	0.000272855499874
ko04514	Cell adhesion molecules (CAMs)	38/1194	130/7206	0.00029175617868
ko04964	Proximal tubule bicarbonate reclamation	13/1194	29/7206	0.0003294897921
ko04014	Ras signaling pathway	69/1194	279/7206	0.000383339357292
ko04072	Phospholipase D signaling pathway	52/1194	197/7206	0.000418470523367
ko05205	Proteoglycans in cancer	25/1194	271/7206	0.000595018990562
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1194	14/7206	0.000650441838667
ko00240	Pyrimidine metabolism	6/1194	110/7206	0.000672297552635
ko05414	Dilated cardiomyopathy	33/1194	112/7206	0.000719708430702
ko04070	Phosphatidylinositol signaling system	33/1194	112/7206	0.000719708430702
ko04750	Inflammatory mediator regulation of TRP channels	35/1194	122/7206	0.000777879720812
ko04146	Peroxisome	4/1194	89/7206	0.000816426818771
ko00520	Amino sugar and nucleotide sugar metabolism	1/1194	55/7206	0.000844238102145
ko00480	Glutathione metabolism	1/1194	55/7206	0.000844238102145
ko04612	Antigen processing and presentation	3/1194	77/7206	0.00101872543622
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1194	182/7206	0.00160597732402
ko03018	RNA degradation	4/1194	84/7206	0.00167528494825
ko05161	Hepatitis B	14/1194	173/7206	0.00174592275694
ko04640	Hematopoietic cell lineage	2/1194	64/7206	0.00186784280595
ko00590	Arachidonic acid metabolism	1/1194	52/7206	0.00205658752481
ko04214	Apoptosis - fly	3/1194	72/7206	0.00214280011073
ko00330	Arginine and proline metabolism	2/1194	61/7206	0.00268278521041
ko04371	Apelin signaling pathway	45/1194	177/7206	0.00278454583719
ko04915	Estrogen signaling pathway	35/1194	131/7206	0.00283943993481
ko00260	Glycine, serine and threonine metabolism	1/1194	48/7206	0.00290473330452
ko04657	IL-17 signaling pathway	5/1194	87/7206	0.00352499460288
ko05144	Malaria	1/1194	45/7206	0.00436718807834
ko00071	Fatty acid degradation	1/1194	45/7206	0.00436718807834
ko03420	Nucleotide excision repair	1/1194	46/7206	0.00441826647441
ko01524	Platinum drug resistance	4/1194	76/7206	0.00479451465707
ko04626	Plant-pathogen interaction	8/1194	18/7206	0.00508839460948
ko05321	Inflammatory bowel disease (IBD)	2/1194	56/7206	0.00578508571409
ko04668	TNF signaling pathway	9/1194	120/7206	0.00597347464739
ko04620	Toll-like receptor signaling pathway	7/1194	100/7206	0.00653117052745
ko03022	Basal transcription factors	1/1194	44/7206	0.00676994931639
ko05418	Fluid shear stress and atherosclerosis	16/1194	173/7206	0.00693443888341
ko05166	HTLV-I infection	32/1194	292/7206	0.00782312857933
ko04622	RIG-I-like receptor signaling pathway	3/1194	62/7206	0.00919312432398
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1194	40/7206	0.00984501979173
ko01200	Carbon metabolism	11/1194	128/7206	0.0115601355286
ko04916	Melanogenesis	35/1194	142/7206	0.0118970410986
ko04658	Th1 and Th2 cell differentiation	7/1194	96/7206	0.0121307016838
ko04912	GnRH signaling pathway	31/1194	122/7206	0.0133008186681
ko00630	Glyoxylate and dicarboxylate metabolism	1/1194	38/7206	0.0147621211043
ko05145	Toxoplasmosis	11/1194	126/7206	0.0151539374626
ko04350	TGF-beta signaling pathway	8/1194	103/7206	0.0153715074683
ko04978	Mineral absorption	13/1194	40/7206	0.0161605859548
ko04015	Rap1 signaling pathway	61/1194	278/7206	0.0168832492441
ko00270	Cysteine and methionine metabolism	2/1194	47/7206	0.0174202391096
ko04630	Jak-STAT signaling pathway	12/1194	132/7206	0.0177382261996
ko04115	p53 signaling pathway	5/1194	74/7206	0.0181591724073
ko00562	Inositol phosphate metabolism	23/1194	89/7206	0.0218197678384
ko00982	Drug metabolism - cytochrome P450	1/1194	37/7206	0.0233039734362
ko05131	Shigellosis	6/1194	82/7206	0.0237823657503
ko00310	Lysine degradation	5/1194	73/7206	0.0252947984769
ko04210	Apoptosis	19/1194	180/7206	0.0255248725345
ko00600	Sphingolipid metabolism	4/1194	63/7206	0.0259843569005
ko04270	Vascular smooth muscle contraction	36/1194	154/7206	0.0278197161534
ko05215	Prostate cancer	10/1194	111/7206	0.0285100576008
ko05133	Pertussis	7/1194	87/7206	0.0291280340822
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1194	100/7206	0.029352671204
ko04923	Regulation of lipolysis in adipocytes	20/1194	77/7206	0.030865977803
ko04140	Autophagy - animal	17/1194	164/7206	0.0329160851665
ko00640	Propanoate metabolism	1/1194	34/7206	0.0338563769531
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1194	92/7206	0.0340097627528
ko00983	Drug metabolism - other enzymes	2/1194	42/7206	0.0364426955823
ko04974	Protein digestion and absorption	24/1194	96/7206	0.0367288509317
ko04330	Notch signaling pathway	4/1194	62/7206	0.0372332502682
ko04930	Type II diabetes mellitus	15/1194	54/7206	0.0405278318956
ko04670	Leukocyte transendothelial migration	16/1194	151/7206	0.0462722104375
ko05214	Glioma	20/1194	79/7206	0.0463714353438