ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 47/504 191/7206 7.05951284397e-15 ko04380 Osteoclast differentiation 32/504 134/7206 3.90310823725e-10 ko04621 NOD-like receptor signaling pathway 35/504 157/7206 4.36939352693e-10 ko05164 Influenza A 34/504 167/7206 9.5038613892e-09 ko00120 Primary bile acid biosynthesis 11/504 20/7206 1.65849174141e-08 ko05321 Inflammatory bowel disease (IBD) 18/504 56/7206 2.07583506535e-08 ko04064 NF-kappa B signaling pathway 23/504 96/7206 1.13240843705e-07 ko05162 Measles 26/504 120/7206 1.49109776953e-07 ko05340 Primary immunodeficiency 12/504 30/7206 3.25108995047e-07 ko05140 Leishmaniasis 19/504 75/7206 5.75748232077e-07 ko04217 Necroptosis 31/504 178/7206 1.65605974e-06 ko04650 Natural killer cell mediated cytotoxicity 21/504 97/7206 2.40965701509e-06 ko05145 Toxoplasmosis 24/504 126/7206 5.13824618811e-06 ko04658 Th1 and Th2 cell differentiation 20/504 96/7206 7.78606380877e-06 ko04659 Th17 cell differentiation 21/504 106/7206 1.06074366142e-05 ko04620 Toll-like receptor signaling pathway 20/504 100/7206 1.48294666855e-05 ko04612 Antigen processing and presentation 17/504 77/7206 1.6749118269e-05 ko05168 Herpes simplex infection 29/504 182/7206 2.30100449406e-05 ko04668 TNF signaling pathway 22/504 120/7206 2.38323299438e-05 ko04672 Intestinal immune network for IgA production 11/504 37/7206 2.82326356801e-05 ko04390 Hippo signaling pathway 1/504 188/7206 3.05226564539e-05 ko05133 Pertussis 17/504 87/7206 8.77345111657e-05 ko04662 B cell receptor signaling pathway 17/504 88/7206 0.00010185452336 ko04660 T cell receptor signaling pathway 21/504 124/7206 0.000121016807535 ko05150 Staphylococcus aureus infection 10/504 36/7206 0.000123885889336 ko05330 Allograft rejection 8/504 24/7206 0.000146278862018 ko03013 RNA transport 1/504 166/7206 0.000147581793159 ko04630 Jak-STAT signaling pathway 22/504 132/7206 0.000170751493105 ko04622 RIG-I-like receptor signaling pathway 13/504 62/7206 0.000284333903776 ko04610 Complement and coagulation cascades 15/504 79/7206 0.000314681134219 ko05152 Tuberculosis 27/504 187/7206 0.000357169870118 ko04623 Cytosolic DNA-sensing pathway 10/504 41/7206 0.000397780270135 ko05161 Hepatitis B 25/504 173/7206 0.000426383767819 ko00051 Fructose and mannose metabolism 10/504 42/7206 0.000490028788188 ko05160 Hepatitis C 23/504 153/7206 0.000537525307175 ko05310 Asthma 6/504 17/7206 0.000722492409201 ko03040 Spliceosome 1/504 145/7206 0.000723493144157 ko00590 Arachidonic acid metabolism 11/504 52/7206 0.000764430755234 ko05332 Graft-versus-host disease 6/504 18/7206 0.00102038967155 ko04640 Hematopoietic cell lineage 12/504 64/7206 0.00138192528972 ko00592 alpha-Linolenic acid metabolism 6/504 19/7206 0.00140428578396 ko03010 Ribosome 1/504 129/7206 0.00144684477904 ko00140 Steroid hormone biosynthesis 9/504 41/7206 0.00173305427393 ko04710 Circadian rhythm 9/504 43/7206 0.00246189917606 ko04210 Apoptosis 24/504 180/7206 0.00257653092906 ko04657 IL-17 signaling pathway 14/504 87/7206 0.00264018283491 ko05320 Autoimmune thyroid disease 7/504 29/7206 0.00316651657108 ko05034 Alcoholism 6/504 238/7206 0.00401278392731 ko04062 Chemokine signaling pathway 25/504 201/7206 0.00452630073043 ko05142 Chagas disease (American trypanosomiasis) 18/504 130/7206 0.00471900646751 ko05323 Rheumatoid arthritis 14/504 89/7206 0.00478819883309 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/504 191/7206 0.00554934575769 ko00350 Tyrosine metabolism 7/504 33/7206 0.00679780588144 ko04310 Wnt signaling pathway 4/504 181/7206 0.00716409881433 ko04611 Platelet activation 21/504 163/7206 0.00723021218229 ko04068 FoxO signaling pathway 21/504 167/7206 0.00817815342965 ko04723 Retrograde endocannabinoid signaling 4/504 175/7206 0.0098615728537 ko04664 Fc epsilon RI signaling pathway 12/504 77/7206 0.010406468244 ko05144 Malaria 8/504 45/7206 0.0117063690083 ko04110 Cell cycle 3/504 145/7206 0.0129348741716 ko04137 Mitophagy - animal 12/504 82/7206 0.0136316537028 ko05134 Legionellosis 11/504 74/7206 0.0177073284812 ko04916 Melanogenesis 3/504 142/7206 0.0183537111057 ko03015 mRNA surveillance pathway 1/504 93/7206 0.021324309323 ko04940 Type I diabetes mellitus 6/504 32/7206 0.0216412357394 ko04727 GABAergic synapse 2/504 110/7206 0.0235857962713 ko05132 Salmonella infection 13/504 98/7206 0.0250223640466 ko04360 Axon guidance 8/504 233/7206 0.0261363618793 ko00360 Phenylalanine metabolism 4/504 17/7206 0.0271002502588 ko04145 Phagosome 19/504 162/7206 0.027191164698 ko00950 Isoquinoline alkaloid biosynthesis 3/504 10/7206 0.028179447731 ko05131 Shigellosis 11/504 82/7206 0.029267286447 ko05224 Breast cancer 5/504 174/7206 0.0332470834048 ko00982 Drug metabolism - cytochrome P450 6/504 37/7206 0.0414196765782 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/504 5/7206 0.0423715348783 ko04550 Signaling pathways regulating pluripotency of stem cells 5/504 165/7206 0.0433492755414 ko04350 TGF-beta signaling pathway 2/504 103/7206 0.0480314823262