ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 50/411 145/7206 6.84949595403e-27 ko04111 Cell cycle - yeast 33/411 90/7206 5.42147547157e-19 ko03030 DNA replication 18/411 38/7206 3.31179948168e-13 ko04113 Meiosis - yeast 22/411 70/7206 1.67957625368e-11 ko03410 Base excision repair 15/411 38/7206 7.88621253875e-10 ko03460 Fanconi anemia pathway 17/411 51/7206 1.26561199251e-09 ko05217 Basal cell carcinoma 19/411 68/7206 3.86481909777e-09 ko03440 Homologous recombination 14/411 41/7206 2.64343775028e-08 ko04330 Notch signaling pathway 17/411 62/7206 3.53662051857e-08 ko03040 Spliceosome 24/411 145/7206 1.88625476579e-06 ko04390 Hippo signaling pathway 28/411 188/7206 2.33295957469e-06 ko00240 Pyrimidine metabolism 20/411 110/7206 3.12358769011e-06 ko05224 Breast cancer 26/411 174/7206 5.07188719876e-06 ko05206 MicroRNAs in cancer 25/411 177/7206 2.10127901394e-05 ko05200 Pathways in cancer 51/411 492/7206 2.83764609811e-05 ko04020 Calcium signaling pathway 2/411 265/7206 3.59782380234e-05 ko03430 Mismatch repair 7/411 22/7206 0.000150502812708 ko04218 Cellular senescence 23/411 177/7206 0.000192127022208 ko04550 Signaling pathways regulating pluripotency of stem cells 22/411 165/7206 0.000211916582766 ko03013 RNA transport 22/411 166/7206 0.000223311137054 ko05166 HTLV-I infection 32/411 292/7206 0.00039952872405 ko05222 Small cell lung cancer 14/411 89/7206 0.000461768167086 ko04310 Wnt signaling pathway 22/411 181/7206 0.000846434624616 ko03420 Nucleotide excision repair 9/411 46/7206 0.000976312940827 ko05215 Prostate cancer 15/411 111/7206 0.0014930185531 ko04621 NOD-like receptor signaling pathway 1/411 157/7206 0.00152337177037 ko04391 Hippo signaling pathway - fly 13/411 90/7206 0.00164931876413 ko05012 Parkinson's disease 1/411 155/7206 0.00230421593413 ko00230 Purine metabolism 22/411 194/7206 0.00231379678053 ko04115 p53 signaling pathway 11/411 74/7206 0.00292876084952 ko05168 Herpes simplex infection 19/411 182/7206 0.00906676148073 ko04724 Glutamatergic synapse 2/411 152/7206 0.0122548133937 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/411 182/7206 0.0137296529688 ko04921 Oxytocin signaling pathway 4/411 209/7206 0.0141500816033 ko04340 Hedgehog signaling pathway 8/411 58/7206 0.0163257335244 ko04916 Melanogenesis 15/411 142/7206 0.0171832155272 ko04910 Insulin signaling pathway 3/411 172/7206 0.0185949308315 ko04072 Phospholipase D signaling pathway 4/411 197/7206 0.0187672398962 ko04723 Retrograde endocannabinoid signaling 3/411 175/7206 0.0190760549256 ko04062 Chemokine signaling pathway 4/411 201/7206 0.0191820669157 ko05010 Alzheimer's disease 4/411 202/7206 0.0193785689681 ko03015 mRNA surveillance pathway 11/411 93/7206 0.0203488592634 ko04727 GABAergic synapse 1/411 110/7206 0.0210336815383 ko05032 Morphine addiction 1/411 110/7206 0.0210336815383 ko05414 Dilated cardiomyopathy 1/411 112/7206 0.0213842639074 ko05203 Viral carcinogenesis 25/411 277/7206 0.0234227566172 ko04726 Serotonergic synapse 2/411 137/7206 0.0243287433261 ko00670 One carbon pool by folate 4/411 20/7206 0.0243918224271 ko04022 cGMP-PKG signaling pathway 5/411 216/7206 0.0247377042005 ko05212 Pancreatic cancer 10/411 83/7206 0.0264567683959 ko01522 Endocrine resistance 13/411 124/7206 0.0295562742973 ko04659 Th17 cell differentiation 1/411 106/7206 0.0312907569081 ko01200 Carbon metabolism 2/411 128/7206 0.0340860342295 ko05216 Thyroid cancer 5/411 34/7206 0.0418306414803 ko04970 Salivary secretion 1/411 95/7206 0.0436379080869 ko04974 Protein digestion and absorption 1/411 96/7206 0.0438049151376 ko04650 Natural killer cell mediated cytotoxicity 1/411 97/7206 0.0441043270646 ko03008 Ribosome biogenesis in eukaryotes 9/411 79/7206 0.0444109312354 ko00564 Glycerophospholipid metabolism 1/411 99/7206 0.0450983386148 ko05410 Hypertrophic cardiomyopathy (HCM) 1/411 100/7206 0.0457921010747 ko04217 Necroptosis 4/411 178/7206 0.0472783413336 ko04066 HIF-1 signaling pathway 2/411 123/7206 0.0478913006713 ko04350 TGF-beta signaling pathway 11/411 103/7206 0.048656585044 ko04142 Lysosome 3/411 151/7206 0.0486695526165