ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 33/364 152/7206 4.43103941869e-13 ko04911 Insulin secretion 24/364 117/7206 2.64138118585e-09 ko04020 Calcium signaling pathway 38/364 265/7206 3.44420545363e-09 ko04713 Circadian entrainment 25/364 136/7206 1.31049069576e-08 ko05032 Morphine addiction 22/364 110/7206 2.02271110854e-08 ko04925 Aldosterone synthesis and secretion 21/364 105/7206 4.27683013732e-08 ko04728 Dopaminergic synapse 28/364 185/7206 1.40248484123e-07 ko04720 Long-term potentiation 19/364 99/7206 3.76904202243e-07 ko05033 Nicotine addiction 14/364 56/7206 4.58048228624e-07 ko04727 GABAergic synapse 20/364 110/7206 4.64573539208e-07 ko04723 Retrograde endocannabinoid signaling 26/364 175/7206 5.76774835602e-07 ko04725 Cholinergic synapse 24/364 160/7206 1.33060346164e-06 ko04024 cAMP signaling pathway 34/364 279/7206 1.68011364731e-06 ko05031 Amphetamine addiction 17/364 91/7206 2.31347158327e-06 ko05030 Cocaine addiction 15/364 73/7206 2.647199132e-06 ko04070 Phosphatidylinositol signaling system 19/364 112/7206 2.69160240849e-06 ko04261 Adrenergic signaling in cardiomyocytes 27/364 205/7206 3.85791106711e-06 ko04742 Taste transduction 13/364 61/7206 8.10483637546e-06 ko04912 GnRH signaling pathway 19/364 122/7206 9.86921777491e-06 ko04072 Phospholipase D signaling pathway 25/364 197/7206 1.71253657536e-05 ko04080 Neuroactive ligand-receptor interaction 42/364 423/7206 1.79966792192e-05 ko04970 Salivary secretion 16/364 95/7206 1.83052852248e-05 ko04740 Olfactory transduction 14/364 80/7206 3.92866139756e-05 ko00515 Mannose type O-glycan biosynthesis 7/364 25/7206 0.000172544298479 ko04010 MAPK signaling pathway 32/364 321/7206 0.000202134085509 ko04022 cGMP-PKG signaling pathway 24/364 216/7206 0.000224730664917 ko04915 Estrogen signaling pathway 17/364 131/7206 0.000294773476877 ko04972 Pancreatic secretion 15/364 111/7206 0.000427857825058 ko00513 Various types of N-glycan biosynthesis 8/364 42/7206 0.0010210995865 ko04921 Oxytocin signaling pathway 22/364 209/7206 0.00102805480975 ko04971 Gastric acid secretion 13/364 98/7206 0.00121701174945 ko00562 Inositol phosphate metabolism 12/364 89/7206 0.00161250281529 ko04144 Endocytosis 30/364 342/7206 0.00322034698365 ko03013 RNA transport 1/364 166/7206 0.00337889239812 ko04320 Dorso-ventral axis formation 6/364 31/7206 0.00400479029412 ko05414 Dilated cardiomyopathy 13/364 112/7206 0.00406915538622 ko04211 Longevity regulating pathway 14/364 123/7206 0.00510800928012 ko04914 Progesterone-mediated oocyte maturation 12/364 104/7206 0.00595737595438 ko04540 Gap junction 14/364 128/7206 0.00625615906188 ko04721 Synaptic vesicle cycle 10/364 80/7206 0.00667951302152 ko04270 Vascular smooth muscle contraction 16/364 154/7206 0.00759147405988 ko05231 Choline metabolism in cancer 14/364 134/7206 0.00840835038367 ko04744 Phototransduction 6/364 36/7206 0.00856848883104 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5/364 26/7206 0.00873933399264 ko04722 Neurotrophin signaling pathway 16/364 160/7206 0.00894114829988 ko04360 Axon guidance 21/364 233/7206 0.0089755905733 ko04726 Serotonergic synapse 14/364 137/7206 0.0098438849682 ko04750 Inflammatory mediator regulation of TRP channels 13/364 122/7206 0.0100575963812 ko04918 Thyroid hormone synthesis 10/364 86/7206 0.0110020479613 ko04745 Phototransduction - fly 6/364 38/7206 0.0111596746206 ko04012 ErbB signaling pathway 12/364 109/7206 0.011987827349 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 5/364 28/7206 0.0120225959119 ko00510 N-Glycan biosynthesis 7/364 50/7206 0.0121113757193 ko00512 Mucin type O-glycan biosynthesis 5/364 29/7206 0.0139411434965 ko04923 Regulation of lipolysis in adipocytes 9/364 77/7206 0.0149998531005 ko04916 Melanogenesis 14/364 142/7206 0.017391874386 ko04145 Phagosome 2/364 162/7206 0.0174720604695 ko05214 Glioma 9/364 79/7206 0.0175293230505 ko04371 Apelin signaling pathway 16/364 177/7206 0.0220781537446 ko04621 NOD-like receptor signaling pathway 2/364 157/7206 0.024946392504 ko04141 Protein processing in endoplasmic reticulum 3/364 184/7206 0.0258198779133 ko05202 Transcriptional misregulation in cancer 3/364 188/7206 0.0262910803952 ko04114 Oocyte meiosis 13/364 139/7206 0.0289344529222 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/364 14/7206 0.0307097791317 ko04062 Chemokine signaling pathway 17/364 201/7206 0.0326601406726 ko00564 Glycerophospholipid metabolism 10/364 99/7206 0.0329469051818 ko04110 Cell cycle 2/364 145/7206 0.034481930233 ko04014 Ras signaling pathway 22/364 279/7206 0.0353457832623 ko05213 Endometrial cancer 7/364 62/7206 0.0357283050119 ko05110 Vibrio cholerae infection 7/364 63/7206 0.0385256245791 ko04514 Cell adhesion molecules (CAMs) 12/364 130/7206 0.0399045509755 ko04924 Renin secretion 9/364 86/7206 0.040118731283 ko04659 Th17 cell differentiation 1/364 106/7206 0.0441443521341 ko00240 Pyrimidine metabolism 1/364 110/7206 0.044809124097 ko05034 Alcoholism 19/364 238/7206 0.0481969728005 ko05020 Prion diseases 5/364 40/7206 0.0493083687856 ko05203 Viral carcinogenesis 7/364 277/7206 0.0494962563483