ko pathway ratio_in_study ratio_in_pop p_value ko04723 Retrograde endocannabinoid signaling 18/166 175/7206 8.75479038295e-08 ko04724 Glutamatergic synapse 16/166 152/7206 3.46595391826e-07 ko04911 Insulin secretion 13/166 117/7206 2.49252200503e-06 ko04020 Calcium signaling pathway 20/166 265/7206 2.5223823733e-06 ko04725 Cholinergic synapse 15/166 160/7206 3.58839087357e-06 ko04261 Adrenergic signaling in cardiomyocytes 17/166 205/7206 4.26905554316e-06 ko04727 GABAergic synapse 12/166 110/7206 7.46573158273e-06 ko05032 Morphine addiction 12/166 110/7206 7.46573158273e-06 ko04072 Phospholipase D signaling pathway 16/166 197/7206 1.08326410049e-05 ko05033 Nicotine addiction 8/166 56/7206 3.71233406906e-05 ko04713 Circadian entrainment 12/166 136/7206 6.4121540447e-05 ko04024 cAMP signaling pathway 18/166 279/7206 6.86815423604e-05 ko04720 Long-term potentiation 10/166 99/7206 8.5501707887e-05 ko04728 Dopaminergic synapse 14/166 185/7206 8.56483039515e-05 ko04921 Oxytocin signaling pathway 15/166 209/7206 8.71941523915e-05 ko04022 cGMP-PKG signaling pathway 15/166 216/7206 0.000126394553091 ko04925 Aldosterone synthesis and secretion 10/166 105/7206 0.00014060872063 ko04080 Neuroactive ligand-receptor interaction 21/166 423/7206 0.000705901907174 ko05231 Choline metabolism in cancer 10/166 134/7206 0.00100263301523 ko04070 Phosphatidylinositol signaling system 9/166 112/7206 0.00106099657353 ko04970 Salivary secretion 8/166 95/7206 0.00148526282775 ko04912 GnRH signaling pathway 9/166 122/7206 0.00193654677186 ko04721 Synaptic vesicle cycle 7/166 80/7206 0.00234830065504 ko00513 Various types of N-glycan biosynthesis 5/166 42/7206 0.00260794802437 ko04514 Cell adhesion molecules (CAMs) 9/166 130/7206 0.00298989922825 ko04915 Estrogen signaling pathway 9/166 131/7206 0.00314839878717 ko04972 Pancreatic secretion 8/166 111/7206 0.00395683552327 ko05414 Dilated cardiomyopathy 8/166 112/7206 0.00417959236552 ko00562 Inositol phosphate metabolism 7/166 89/7206 0.00428714774274 ko04750 Inflammatory mediator regulation of TRP channels 8/166 122/7206 0.00697746328031 ko04666 Fc gamma R-mediated phagocytosis 8/166 122/7206 0.00697746328031 ko04971 Gastric acid secretion 7/166 98/7206 0.00724875040584 ko04371 Apelin signaling pathway 10/166 177/7206 0.00758505193963 ko04270 Vascular smooth muscle contraction 9/166 154/7206 0.00900272478342 ko04540 Gap junction 8/166 128/7206 0.00922889572704 ko04740 Olfactory transduction 6/166 80/7206 0.0100678413778 ko04745 Phototransduction - fly 4/166 38/7206 0.0108962885152 ko04722 Neurotrophin signaling pathway 9/166 160/7206 0.0114058243637 ko04071 Sphingolipid signaling pathway 9/166 162/7206 0.0123050715991 ko04144 Endocytosis 15/166 342/7206 0.0148099163973 ko04010 MAPK signaling pathway 14/166 321/7206 0.0201010167637 ko05203 Viral carcinogenesis 1/166 277/7206 0.0221301193743 ko00512 Mucin type O-glycan biosynthesis 3/166 29/7206 0.0282909517487 ko05142 Chagas disease (American trypanosomiasis) 7/166 130/7206 0.0301758280475 ko04923 Regulation of lipolysis in adipocytes 5/166 77/7206 0.031921420784 ko04914 Progesterone-mediated oocyte maturation 6/166 104/7206 0.0325105418005 ko04011 MAPK signaling pathway - yeast 4/166 53/7206 0.033187139418 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5/166 79/7206 0.0351179907604 ko05230 Central carbon metabolism in cancer 5/166 81/7206 0.0385061890233 ko04012 ErbB signaling pathway 6/166 109/7206 0.0395542422313 ko00604 Glycosphingolipid biosynthesis - ganglio series 2/166 14/7206 0.0400331447291 ko04114 Oocyte meiosis 7/166 139/7206 0.0411466788385 ko04916 Melanogenesis 7/166 142/7206 0.0453142310825 ko04213 Longevity regulating pathway - multiple species 5/166 86/7206 0.0478271001343 ko04924 Renin secretion 5/166 86/7206 0.0478271001343