ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 133/852 423/7206 6.35288024143e-29 ko04724 Glutamatergic synapse 67/852 152/7206 5.03855047969e-24 ko05033 Nicotine addiction 37/852 56/7206 1.11416197977e-21 ko05032 Morphine addiction 53/852 110/7206 2.00158124727e-21 ko04727 GABAergic synapse 51/852 110/7206 1.00934997809e-19 ko04713 Circadian entrainment 56/852 136/7206 1.51543781494e-18 ko04728 Dopaminergic synapse 67/852 185/7206 2.07341904531e-18 ko04723 Retrograde endocannabinoid signaling 61/852 175/7206 6.14329947804e-16 ko04024 cAMP signaling pathway 82/852 279/7206 8.14769168846e-16 ko04721 Synaptic vesicle cycle 36/852 80/7206 8.83946981548e-14 ko04725 Cholinergic synapse 54/852 160/7206 1.42094692403e-13 ko04744 Phototransduction 22/852 36/7206 2.30919277336e-12 ko04921 Oxytocin signaling pathway 60/852 209/7206 1.9224449304e-11 ko04911 Insulin secretion 40/852 117/7206 1.42222969127e-10 ko04726 Serotonergic synapse 44/852 137/7206 1.75507918283e-10 ko04020 Calcium signaling pathway 66/852 265/7206 1.50168291904e-09 ko04261 Adrenergic signaling in cardiomyocytes 55/852 205/7206 2.05919116046e-09 ko04742 Taste transduction 24/852 61/7206 3.25897894802e-08 ko04720 Long-term potentiation 32/852 99/7206 4.69473812644e-08 ko05031 Amphetamine addiction 30/852 91/7206 7.50524044076e-08 ko04070 Phosphatidylinositol signaling system 34/852 112/7206 1.0209940106e-07 ko05203 Viral carcinogenesis 10/852 277/7206 1.5063562618e-06 ko04010 MAPK signaling pathway 67/852 321/7206 2.10281069097e-06 ko03040 Spliceosome 2/852 145/7206 3.33611040923e-06 ko05030 Cocaine addiction 23/852 73/7206 5.97011097908e-06 ko04970 Salivary secretion 27/852 95/7206 8.43979693623e-06 ko04514 Cell adhesion molecules (CAMs) 32/852 130/7206 4.50771874177e-05 ko04072 Phospholipase D signaling pathway 43/852 197/7206 4.70061981996e-05 ko04730 Long-term depression 22/852 78/7206 6.48127985749e-05 ko03013 RNA transport 5/852 166/7206 7.67897909121e-05 ko04925 Aldosterone synthesis and secretion 27/852 105/7206 8.55504516247e-05 ko05322 Systemic lupus erythematosus 4/852 151/7206 9.70389658579e-05 ko04022 cGMP-PKG signaling pathway 45/852 216/7206 0.00014859394905 ko04260 Cardiac muscle contraction 25/852 98/7206 0.000186534483264 ko00562 Inositol phosphate metabolism 23/852 89/7206 0.000205089255124 ko04972 Pancreatic secretion 27/852 111/7206 0.000266334318396 ko04060 Cytokine-cytokine receptor interaction 8/852 191/7206 0.000366992866009 ko04360 Axon guidance 46/852 233/7206 0.000398837041223 ko05168 Herpes simplex infection 8/852 182/7206 0.000679534401955 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/852 79/7206 0.000704650759654 ko05014 Amyotrophic lateral sclerosis (ALS) 19/852 74/7206 0.000826014722265 ko05164 Influenza A 7/852 167/7206 0.000931429326397 ko04610 Complement and coagulation cascades 1/852 79/7206 0.00119237440581 ko03008 Ribosome biogenesis in eukaryotes 1/852 79/7206 0.00119237440581 ko04014 Ras signaling pathway 51/852 279/7206 0.00123404456333 ko04740 Olfactory transduction 20/852 80/7206 0.00125848866853 ko04915 Estrogen signaling pathway 28/852 131/7206 0.00150528036734 ko04966 Collecting duct acid secretion 9/852 26/7206 0.0020844684087 ko04621 NOD-like receptor signaling pathway 7/852 157/7206 0.00241833906422 ko04710 Circadian rhythm 12/852 43/7206 0.00324261147288 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/852 14/7206 0.00348016287237 ko04745 Phototransduction - fly 11/852 38/7206 0.00348457087717 ko04964 Proximal tubule bicarbonate reclamation 9/852 29/7206 0.00482188637262 ko05169 Epstein-Barr virus infection 12/852 206/7206 0.00581691062172 ko04110 Cell cycle 7/852 145/7206 0.00593553399292 ko04971 Gastric acid secretion 21/852 98/7206 0.00650862720212 ko04960 Aldosterone-regulated sodium reabsorption 11/852 41/7206 0.00657327463249 ko05414 Dilated cardiomyopathy 23/852 112/7206 0.00727081382546 ko05410 Hypertrophic cardiomyopathy (HCM) 21/852 100/7206 0.00742369373392 ko04146 Peroxisome 3/852 89/7206 0.00783664263944 ko05110 Vibrio cholerae infection 15/852 63/7206 0.00893865646142 ko04141 Protein processing in endoplasmic reticulum 11/852 184/7206 0.0105449620443 ko05205 Proteoglycans in cancer 19/852 271/7206 0.012226735189 ko04973 Carbohydrate digestion and absorption 11/852 42/7206 0.0129656208305 ko04711 Circadian rhythm - fly 5/852 13/7206 0.0130169397704 ko04071 Sphingolipid signaling pathway 30/852 162/7206 0.0130527357227 ko04626 Plant-pathogen interaction 6/852 18/7206 0.014216757098 ko05162 Measles 6/852 120/7206 0.0150666468112 ko05131 Shigellosis 3/852 82/7206 0.0155220750207 ko04064 NF-kappa B signaling pathway 4/852 96/7206 0.0159617910858 ko04924 Renin secretion 18/852 86/7206 0.0168530372623 ko00590 Arachidonic acid metabolism 1/852 52/7206 0.017530929075 ko05231 Choline metabolism in cancer 25/852 134/7206 0.0205629075757 ko04120 Ubiquitin mediated proteolysis 8/852 138/7206 0.0232991643494 ko04371 Apelin signaling pathway 31/852 177/7206 0.0242996968045 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/852 15/7206 0.0248590860313 ko00513 Various types of N-glycan biosynthesis 10/852 42/7206 0.0268172501832 ko05140 Leishmaniasis 3/852 75/7206 0.0303243440078 ko04930 Type II diabetes mellitus 12/852 54/7206 0.0305712055294 ko04612 Antigen processing and presentation 3/852 77/7206 0.0310103947532 ko04217 Necroptosis 12/852 178/7206 0.0336503389787 ko05010 Alzheimer's disease 34/852 202/7206 0.034779099872 ko05230 Central carbon metabolism in cancer 16/852 81/7206 0.0359546706403 ko00240 Pyrimidine metabolism 6/852 110/7206 0.0362478267203 ko04922 Glucagon signaling pathway 23/852 128/7206 0.0373415988505 ko04540 Gap junction 23/852 128/7206 0.0373415988505 ko03420 Nucleotide excision repair 1/852 46/7206 0.0377156658705 ko05204 Chemical carcinogenesis 1/852 48/7206 0.0393032706581 ko05161 Hepatitis B 12/852 173/7206 0.0425370330391 ko04750 Inflammatory mediator regulation of TRP channels 22/852 122/7206 0.0458990202266 ko04919 Thyroid hormone signaling pathway 25/852 143/7206 0.0481654417377