ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 15/154 56/7206 3.41035107902e-13 ko04724 Glutamatergic synapse 18/154 152/7206 2.82575695732e-09 ko04721 Synaptic vesicle cycle 11/154 80/7206 8.75256895957e-07 ko04080 Neuroactive ligand-receptor interaction 25/154 423/7206 2.80585349568e-06 ko04723 Retrograde endocannabinoid signaling 14/154 175/7206 2.00958518254e-05 ko04727 GABAergic synapse 11/154 110/7206 2.05331169504e-05 ko04024 cAMP signaling pathway 17/154 279/7206 8.74342061415e-05 ko04514 Cell adhesion molecules (CAMs) 11/154 130/7206 9.6995049664e-05 ko05032 Morphine addiction 10/154 110/7206 0.00011141744463 ko05030 Cocaine addiction 8/154 73/7206 0.000150285090362 ko04728 Dopaminergic synapse 13/154 185/7206 0.000152560871866 ko05014 Amyotrophic lateral sclerosis (ALS) 8/154 74/7206 0.000165489578781 ko04742 Taste transduction 7/154 61/7206 0.000294455648711 ko04713 Circadian entrainment 10/154 136/7206 0.000628512701697 ko05031 Amphetamine addiction 8/154 91/7206 0.000687086409895 ko04720 Long-term potentiation 8/154 99/7206 0.00119878131916 ko04020 Calcium signaling pathway 13/154 265/7206 0.00428096117118 ko04010 MAPK signaling pathway 14/154 321/7206 0.00937586200788 ko04921 Oxytocin signaling pathway 10/154 209/7206 0.013858477936 ko04144 Endocytosis 14/154 342/7206 0.0189334269333 ko04930 Type II diabetes mellitus 4/154 54/7206 0.0277684706518 ko05205 Proteoglycans in cancer 1/154 271/7206 0.031322180276 ko05203 Viral carcinogenesis 1/154 277/7206 0.0315728695595 ko00604 Glycosphingolipid biosynthesis - ganglio series 2/154 14/7206 0.0348973881183 ko04911 Insulin secretion 6/154 117/7206 0.0389141476208 ko02024 Quorum sensing 2/154 15/7206 0.0397114566221 ko04920 Adipocytokine signaling pathway 5/154 89/7206 0.0413625539595 ko04261 Adrenergic signaling in cardiomyocytes 9/154 205/7206 0.042430039527