ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/998	423/7206	6.42163598962e-49
ko05033	Nicotine addiction	46/998	56/7206	1.1403828092e-30
ko04724	Glutamatergic synapse	79/998	152/7206	1.44935003353e-29
ko05032	Morphine addiction	61/998	110/7206	4.89308851698e-25
ko04727	GABAergic synapse	60/998	110/7206	3.94013150185e-24
ko04713	Circadian entrainment	66/998	136/7206	1.14575773575e-22
ko04723	Retrograde endocannabinoid signaling	71/998	175/7206	9.21414221337e-19
ko04728	Dopaminergic synapse	73/998	185/7206	1.90670645295e-18
ko04721	Synaptic vesicle cycle	43/998	80/7206	2.67307491062e-17
ko04725	Cholinergic synapse	64/998	160/7206	1.19010705035e-16
ko04742	Taste transduction	34/998	61/7206	1.42362907436e-14
ko04024	cAMP signaling pathway	87/998	279/7206	2.85680971591e-14
ko04744	Phototransduction	25/998	36/7206	3.42453003974e-14
ko04726	Serotonergic synapse	53/998	137/7206	2.71662262735e-13
ko04911	Insulin secretion	46/998	117/7206	5.39186494131e-12
ko04921	Oxytocin signaling pathway	67/998	209/7206	6.82304314769e-12
ko04740	Olfactory transduction	34/998	80/7206	2.78541605653e-10
ko04020	Calcium signaling pathway	75/998	265/7206	3.13212566078e-10
ko05031	Amphetamine addiction	36/998	91/7206	9.26718714343e-10
ko04261	Adrenergic signaling in cardiomyocytes	61/998	205/7206	1.86674701908e-09
ko05203	Viral carcinogenesis	10/998	277/7206	1.27639804539e-08
ko04720	Long-term potentiation	36/998	99/7206	1.33843761015e-08
ko04970	Salivary secretion	35/998	95/7206	1.44081595021e-08
ko03040	Spliceosome	1/998	145/7206	1.44362630808e-08
ko05030	Cocaine addiction	29/998	73/7206	3.61521173346e-08
ko05168	Herpes simplex infection	5/998	182/7206	5.66454997742e-07
ko05164	Influenza A	4/998	167/7206	6.00172801055e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/998	74/7206	8.12246656038e-07
ko04925	Aldosterone synthesis and secretion	33/998	105/7206	2.67987965909e-06
ko05322	Systemic lupus erythematosus	4/998	151/7206	3.96122667887e-06
ko04060	Cytokine-cytokine receptor interaction	8/998	191/7206	1.62184268195e-05
ko03013	RNA transport	6/998	166/7206	1.85773355086e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/998	79/7206	1.87761382319e-05
ko04260	Cardiac muscle contraction	30/998	98/7206	1.98673195071e-05
ko04971	Gastric acid secretion	30/998	98/7206	1.98673195071e-05
ko04120	Ubiquitin mediated proteolysis	4/998	138/7206	2.71936671323e-05
ko04514	Cell adhesion molecules (CAMs)	36/998	130/7206	2.80924782133e-05
ko05169	Epstein-Barr virus infection	10/998	206/7206	3.458140163e-05
ko04972	Pancreatic secretion	32/998	111/7206	3.66863527584e-05
ko04730	Long-term depression	25/998	78/7206	3.67922176505e-05
ko05162	Measles	3/998	120/7206	4.3155880087e-05
ko04010	MAPK signaling pathway	71/998	321/7206	4.41120560278e-05
ko04964	Proximal tubule bicarbonate reclamation	13/998	29/7206	5.02448747766e-05
ko04621	NOD-like receptor signaling pathway	7/998	157/7206	0.000158528262962
ko04610	Complement and coagulation cascades	1/998	79/7206	0.000206381428904
ko05205	Proteoglycans in cancer	18/998	271/7206	0.000213846328611
ko04540	Gap junction	33/998	128/7206	0.00025927733941
ko04141	Protein processing in endoplasmic reticulum	10/998	184/7206	0.000318666010128
ko04745	Phototransduction - fly	14/998	38/7206	0.000329599645618
ko04966	Collecting duct acid secretion	11/998	26/7206	0.000358068028365
ko04022	cGMP-PKG signaling pathway	49/998	216/7206	0.000407891086885
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/998	182/7206	0.00043952477238
ko04214	Apoptosis - fly	1/998	72/7206	0.000448648824644
ko04110	Cell cycle	7/998	145/7206	0.000594733711401
ko04924	Renin secretion	24/998	86/7206	0.000725323880542
ko05166	HTLV-I infection	22/998	292/7206	0.00094722846868
ko03008	Ribosome biogenesis in eukaryotes	2/998	79/7206	0.00146933199042
ko04146	Peroxisome	3/998	89/7206	0.00173484077422
ko05140	Leishmaniasis	2/998	75/7206	0.00208331683414
ko04064	NF-kappa B signaling pathway	4/998	96/7206	0.00275273096132
ko04976	Bile secretion	21/998	80/7206	0.00290780666055
ko04072	Phospholipase D signaling pathway	42/998	197/7206	0.00329821025565
ko05414	Dilated cardiomyopathy	27/998	112/7206	0.00335865505784
ko04070	Phosphatidylinositol signaling system	27/998	112/7206	0.00335865505784
ko04360	Axon guidance	48/998	233/7206	0.00370332156167
ko05016	Huntington's disease	16/998	215/7206	0.00474643092913
ko00280	Valine, leucine and isoleucine degradation	1/998	54/7206	0.00497983824436
ko00520	Amino sugar and nucleotide sugar metabolism	1/998	55/7206	0.00506033556535
ko00480	Glutathione metabolism	1/998	55/7206	0.00506033556535
ko05110	Vibrio cholerae infection	17/998	63/7206	0.00518349513997
ko05161	Hepatitis B	12/998	173/7206	0.00524741634612
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/998	59/7206	0.00676643521452
ko04612	Antigen processing and presentation	3/998	77/7206	0.00724052653821
ko00590	Arachidonic acid metabolism	1/998	52/7206	0.00751591028519
ko04657	IL-17 signaling pathway	4/998	87/7206	0.00761956270333
ko05215	Prostate cancer	6/998	111/7206	0.00779578041871
ko04217	Necroptosis	13/998	178/7206	0.00813699766233
ko04978	Mineral absorption	12/998	40/7206	0.00877734569947
ko04330	Notch signaling pathway	2/998	62/7206	0.00922772494782
ko04640	Hematopoietic cell lineage	2/998	64/7206	0.00953380718835
ko00310	Lysine degradation	3/998	73/7206	0.0102262414768
ko03018	RNA degradation	4/998	84/7206	0.0106313077689
ko05219	Bladder cancer	1/998	48/7206	0.010996919159
ko04750	Inflammatory mediator regulation of TRP channels	27/998	122/7206	0.0114466237251
ko04140	Autophagy - animal	12/998	164/7206	0.0116181472469
ko05410	Hypertrophic cardiomyopathy (HCM)	23/998	100/7206	0.0123340191095
ko04014	Ras signaling pathway	53/998	279/7206	0.0133039868999
ko05418	Fluid shear stress and atherosclerosis	13/998	173/7206	0.0136971939233
ko00330	Arginine and proline metabolism	2/998	61/7206	0.0137635907704
ko04915	Estrogen signaling pathway	28/998	131/7206	0.0152160969053
ko04930	Type II diabetes mellitus	14/998	54/7206	0.0161379002633
ko05144	Malaria	1/998	45/7206	0.0163006982769
ko00071	Fatty acid degradation	1/998	45/7206	0.0163006982769
ko03420	Nucleotide excision repair	1/998	46/7206	0.016509971039
ko00240	Pyrimidine metabolism	7/998	110/7206	0.0178416116339
ko05321	Inflammatory bowel disease (IBD)	2/998	56/7206	0.0191830275546
ko01200	Carbon metabolism	9/998	128/7206	0.0201078978317
ko04668	TNF signaling pathway	8/998	120/7206	0.0223712084072
ko03022	Basal transcription factors	1/998	44/7206	0.0252405551362
ko04658	Th1 and Th2 cell differentiation	6/998	96/7206	0.0255721206992
ko05133	Pertussis	5/998	87/7206	0.0274169150467
ko01524	Platinum drug resistance	4/998	76/7206	0.0285001273006
ko04626	Plant-pathogen interaction	6/998	18/7206	0.0293680935624
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/998	14/7206	0.0343165557359
ko04218	Cellular senescence	15/998	177/7206	0.0358740584624
ko05131	Shigellosis	5/998	82/7206	0.0367697271139
ko04115	p53 signaling pathway	4/998	74/7206	0.04000935355
ko04622	RIG-I-like receptor signaling pathway	3/998	62/7206	0.0402953136397
ko00561	Glycerolipid metabolism	3/998	63/7206	0.0411653535755
ko00600	Sphingolipid metabolism	3/998	63/7206	0.0411653535755
ko00562	Inositol phosphate metabolism	19/998	89/7206	0.0447500623587
ko04371	Apelin signaling pathway	34/998	177/7206	0.046412551318
ko04210	Apoptosis	16/998	180/7206	0.0493887847365