ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	169/855	423/7206	2.63590360035e-53
ko05033	Nicotine addiction	48/855	56/7206	6.23757821104e-37
ko04724	Glutamatergic synapse	77/855	152/7206	1.56481694887e-32
ko04727	GABAergic synapse	57/855	110/7206	6.04299139518e-25
ko05032	Morphine addiction	57/855	110/7206	6.04299139518e-25
ko04713	Circadian entrainment	61/855	136/7206	2.32063516462e-22
ko04728	Dopaminergic synapse	72/855	185/7206	9.66889333051e-22
ko04723	Retrograde endocannabinoid signaling	68/855	175/7206	1.54601010716e-20
ko04721	Synaptic vesicle cycle	42/855	80/7206	5.94387055134e-19
ko04725	Cholinergic synapse	62/855	160/7206	9.69336747329e-19
ko04024	cAMP signaling pathway	82/855	279/7206	9.08182219846e-16
ko04911	Insulin secretion	45/855	117/7206	8.86642689929e-14
ko04020	Calcium signaling pathway	73/855	265/7206	1.14758589179e-12
ko04921	Oxytocin signaling pathway	62/855	209/7206	1.81795126093e-12
ko04726	Serotonergic synapse	46/855	137/7206	1.33470409925e-11
ko04742	Taste transduction	28/855	61/7206	3.17483063401e-11
ko05031	Amphetamine addiction	35/855	91/7206	5.31628898017e-11
ko04720	Long-term potentiation	36/855	99/7206	1.83205563492e-10
ko04261	Adrenergic signaling in cardiomyocytes	57/855	205/7206	3.62866419468e-10
ko05030	Cocaine addiction	27/855	73/7206	2.32531784609e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	26/855	74/7206	1.41557959793e-07
ko03040	Spliceosome	1/855	145/7206	3.5003627842e-07
ko04970	Salivary secretion	29/855	95/7206	8.41088609862e-07
ko04060	Cytokine-cytokine receptor interaction	4/855	191/7206	1.10594280572e-06
ko05203	Viral carcinogenesis	10/855	277/7206	1.52263879385e-06
ko04010	MAPK signaling pathway	67/855	321/7206	2.24968162633e-06
ko05168	Herpes simplex infection	4/855	182/7206	2.29894955542e-06
ko04925	Aldosterone synthesis and secretion	30/855	105/7206	4.13301859614e-06
ko04971	Gastric acid secretion	28/855	98/7206	5.51556321509e-06
ko04744	Phototransduction	15/855	36/7206	5.74249183126e-06
ko04514	Cell adhesion molecules (CAMs)	34/855	130/7206	6.18831118729e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/855	79/7206	8.11102338056e-06
ko05164	Influenza A	4/855	167/7206	1.51734220738e-05
ko04730	Long-term depression	23/855	78/7206	2.1460486802e-05
ko04072	Phospholipase D signaling pathway	44/855	197/7206	2.64073823937e-05
ko04972	Pancreatic secretion	29/855	111/7206	3.69043573947e-05
ko04120	Ubiquitin mediated proteolysis	3/855	138/7206	4.96014747352e-05
ko04966	Collecting duct acid secretion	11/855	26/7206	8.77825779138e-05
ko04621	NOD-like receptor signaling pathway	5/855	157/7206	0.000152702888842
ko04260	Cardiac muscle contraction	25/855	98/7206	0.000191606513051
ko03013	RNA transport	6/855	166/7206	0.000238466062427
ko05322	Systemic lupus erythematosus	5/855	151/7206	0.000306202126197
ko04022	cGMP-PKG signaling pathway	43/855	216/7206	0.000555698074233
ko05414	Dilated cardiomyopathy	26/855	112/7206	0.00059327124033
ko04141	Protein processing in endoplasmic reticulum	8/855	184/7206	0.000699497438784
ko04915	Estrogen signaling pathway	29/855	131/7206	0.000867613134076
ko05169	Epstein-Barr virus infection	10/855	206/7206	0.000919823248344
ko04745	Phototransduction - fly	12/855	38/7206	0.00103124506403
ko04924	Renin secretion	21/855	86/7206	0.00108244879583
ko04612	Antigen processing and presentation	1/855	77/7206	0.00113233078962
ko04540	Gap junction	28/855	128/7206	0.001260561228
ko04740	Olfactory transduction	20/855	80/7206	0.0012784025054
ko05162	Measles	4/855	120/7206	0.00153390086213
ko04110	Cell cycle	6/855	145/7206	0.00171322003004
ko04360	Axon guidance	44/855	233/7206	0.00183710158021
ko04350	TGF-beta signaling pathway	3/855	103/7206	0.00192346421673
ko05110	Vibrio cholerae infection	16/855	63/7206	0.00255857123098
ko05205	Proteoglycans in cancer	17/855	271/7206	0.00281823853728
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/855	14/7206	0.00354349319613
ko04064	NF-kappa B signaling pathway	3/855	96/7206	0.00389961227887
ko00240	Pyrimidine metabolism	4/855	110/7206	0.00427653109364
ko04070	Phosphatidylinositol signaling system	24/855	112/7206	0.004485062943
ko03008	Ribosome biogenesis in eukaryotes	2/855	79/7206	0.00481512545219
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/855	182/7206	0.00504293761413
ko04640	Hematopoietic cell lineage	1/855	64/7206	0.00552637294011
ko04750	Inflammatory mediator regulation of TRP channels	25/855	122/7206	0.00655066169849
ko05410	Hypertrophic cardiomyopathy (HCM)	21/855	100/7206	0.00760575471519
ko04146	Peroxisome	3/855	89/7206	0.00782269180413
ko04014	Ras signaling pathway	48/855	279/7206	0.0078714029787
ko05161	Hepatitis B	10/855	173/7206	0.00874441938691
ko00310	Lysine degradation	2/855	73/7206	0.0099997633128
ko04930	Type II diabetes mellitus	13/855	54/7206	0.0100535387741
ko05140	Leishmaniasis	2/855	75/7206	0.0104336242647
ko05016	Huntington's disease	14/855	215/7206	0.013239086719
ko04630	Jak-STAT signaling pathway	7/855	132/7206	0.0142676212492
ko03018	RNA degradation	3/855	84/7206	0.0159282498152
ko04964	Proximal tubule bicarbonate reclamation	8/855	29/7206	0.0167082603449
ko04217	Necroptosis	11/855	178/7206	0.01809339068
ko00480	Glutathione metabolism	1/855	55/7206	0.0184538077986
ko04510	Focal adhesion	17/855	240/7206	0.0190594234992
ko04550	Signaling pathways regulating pluripotency of stem cells	10/855	165/7206	0.0197902166176
ko00562	Inositol phosphate metabolism	18/855	89/7206	0.0200618818389
ko05166	HTLV-I infection	22/855	292/7206	0.020409084244
ko04015	Rap1 signaling pathway	45/855	278/7206	0.029072145338
ko04330	Notch signaling pathway	2/855	62/7206	0.029212689224
ko04657	IL-17 signaling pathway	4/855	87/7206	0.0299285944007
ko04976	Bile secretion	16/855	80/7206	0.0346733761031
ko04071	Sphingolipid signaling pathway	28/855	162/7206	0.0363626805878
ko04140	Autophagy - animal	11/855	164/7206	0.0374550250666
ko00071	Fatty acid degradation	1/855	45/7206	0.0376670355026
ko03420	Nucleotide excision repair	1/855	46/7206	0.0377193378743
ko05219	Bladder cancer	1/855	48/7206	0.0394943997269
ko04214	Apoptosis - fly	3/855	72/7206	0.0422854136676
ko00330	Arginine and proline metabolism	2/855	61/7206	0.0432411671497
ko04371	Apelin signaling pathway	30/855	177/7206	0.0443179921916
ko04912	GnRH signaling pathway	22/855	122/7206	0.0463024737451
ko04923	Regulation of lipolysis in adipocytes	15/855	77/7206	0.049120403652