ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	166/1030	423/7206	2.13030429764e-39
ko05033	Nicotine addiction	47/1030	56/7206	1.61845442657e-31
ko04724	Glutamatergic synapse	81/1030	152/7206	2.60481757388e-30
ko04727	GABAergic synapse	59/1030	110/7206	1.60535674473e-22
ko05032	Morphine addiction	58/1030	110/7206	1.15455072423e-21
ko04713	Circadian entrainment	65/1030	136/7206	4.08708894621e-21
ko04728	Dopaminergic synapse	76/1030	185/7206	1.45928921052e-19
ko04725	Cholinergic synapse	68/1030	160/7206	1.47054294369e-18
ko04721	Synaptic vesicle cycle	45/1030	80/7206	1.51822514234e-18
ko04723	Retrograde endocannabinoid signaling	71/1030	175/7206	5.52467873629e-18
ko04024	cAMP signaling pathway	91/1030	279/7206	1.8620307764e-15
ko04742	Taste transduction	34/1030	61/7206	3.70428528054e-14
ko04744	Phototransduction	24/1030	36/7206	9.29514128013e-13
ko04911	Insulin secretion	47/1030	117/7206	4.00923288463e-12
ko04726	Serotonergic synapse	51/1030	137/7206	1.47659305428e-11
ko04921	Oxytocin signaling pathway	66/1030	209/7206	1.29179942736e-10
ko04720	Long-term potentiation	40/1030	99/7206	1.32799623628e-10
ko05031	Amphetamine addiction	37/1030	91/7206	5.33026172589e-10
ko04020	Calcium signaling pathway	76/1030	265/7206	5.54685126513e-10
ko04261	Adrenergic signaling in cardiomyocytes	62/1030	205/7206	2.90137285844e-09
ko03040	Spliceosome	1/1030	145/7206	5.73146137507e-09
ko05203	Viral carcinogenesis	11/1030	277/7206	1.99456571543e-08
ko04740	Olfactory transduction	31/1030	80/7206	5.19148620998e-08
ko05030	Cocaine addiction	29/1030	73/7206	7.36118111594e-08
ko04360	Axon guidance	64/1030	233/7206	9.72645094169e-08
ko04060	Cytokine-cytokine receptor interaction	6/1030	191/7206	3.15298384473e-07
ko05168	Herpes simplex infection	6/1030	182/7206	1.45157248522e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1030	74/7206	1.529134684e-06
ko03013	RNA transport	5/1030	166/7206	1.59483178133e-06
ko05164	Influenza A	5/1030	167/7206	1.615055244e-06
ko04970	Salivary secretion	32/1030	95/7206	1.71018257434e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1030	79/7206	1.92301083911e-06
ko04010	MAPK signaling pathway	77/1030	321/7206	2.59619263011e-06
ko04925	Aldosterone synthesis and secretion	33/1030	105/7206	6.65751050974e-06
ko04120	Ubiquitin mediated proteolysis	4/1030	138/7206	1.17548563524e-05
ko04971	Gastric acid secretion	31/1030	98/7206	1.27932114333e-05
ko04621	NOD-like receptor signaling pathway	6/1030	157/7206	2.48626236443e-05
ko05169	Epstein-Barr virus infection	11/1030	206/7206	4.67016445857e-05
ko05322	Systemic lupus erythematosus	6/1030	151/7206	5.02795294876e-05
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/1030	182/7206	6.21012657211e-05
ko04141	Protein processing in endoplasmic reticulum	9/1030	184/7206	6.31585767682e-05
ko05205	Proteoglycans in cancer	18/1030	271/7206	8.9086470923e-05
ko04260	Cardiac muscle contraction	29/1030	98/7206	0.000103548155509
ko04514	Cell adhesion molecules (CAMs)	35/1030	130/7206	0.000124377194907
ko03008	Ribosome biogenesis in eukaryotes	1/1030	79/7206	0.000130114379481
ko04730	Long-term depression	24/1030	78/7206	0.000220382807182
ko04022	cGMP-PKG signaling pathway	51/1030	216/7206	0.000224861561252
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1030	14/7206	0.000228368926141
ko04072	Phospholipase D signaling pathway	47/1030	197/7206	0.000268955899562
ko04924	Renin secretion	25/1030	86/7206	0.000471882704886
ko04972	Pancreatic secretion	30/1030	111/7206	0.000497930790488
ko05162	Measles	5/1030	120/7206	0.000522581256741
ko05414	Dilated cardiomyopathy	30/1030	112/7206	0.000530256215509
ko04070	Phosphatidylinositol signaling system	30/1030	112/7206	0.000530256215509
ko04064	NF-kappa B signaling pathway	3/1030	96/7206	0.000575564736669
ko05145	Toxoplasmosis	6/1030	126/7206	0.00112908468672
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1030	59/7206	0.00115610347117
ko04540	Gap junction	32/1030	128/7206	0.00124768093769
ko05140	Leishmaniasis	2/1030	75/7206	0.00137996402279
ko00240	Pyrimidine metabolism	5/1030	110/7206	0.00144665706513
ko04745	Phototransduction - fly	13/1030	38/7206	0.00161855398245
ko04214	Apoptosis - fly	2/1030	72/7206	0.002018897093
ko04966	Collecting duct acid secretion	10/1030	26/7206	0.00204778685038
ko04915	Estrogen signaling pathway	32/1030	131/7206	0.00220315847932
ko03018	RNA degradation	3/1030	84/7206	0.00245994840686
ko04014	Ras signaling pathway	58/1030	279/7206	0.00286491536864
ko00480	Glutathione metabolism	1/1030	55/7206	0.00326873605764
ko05321	Inflammatory bowel disease (IBD)	1/1030	56/7206	0.0033057338857
ko04110	Cell cycle	9/1030	145/7206	0.00368140036271
ko00590	Arachidonic acid metabolism	1/1030	52/7206	0.00487966947866
ko04612	Antigen processing and presentation	3/1030	77/7206	0.00496255305869
ko04146	Peroxisome	4/1030	89/7206	0.00542748015055
ko04640	Hematopoietic cell lineage	2/1030	64/7206	0.00629234658454
ko05161	Hepatitis B	13/1030	173/7206	0.00801361798563
ko04750	Inflammatory mediator regulation of TRP channels	28/1030	122/7206	0.00874637875998
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1030	100/7206	0.00889908943672
ko00330	Arginine and proline metabolism	2/1030	61/7206	0.00911268411029
ko04930	Type II diabetes mellitus	15/1030	54/7206	0.00947137642544
ko04976	Bile secretion	20/1030	80/7206	0.00957640402549
ko03420	Nucleotide excision repair	1/1030	46/7206	0.0108344726963
ko04630	Jak-STAT signaling pathway	9/1030	132/7206	0.0114789223517
ko04217	Necroptosis	14/1030	178/7206	0.0121462231619
ko01200	Carbon metabolism	9/1030	128/7206	0.0150611856644
ko03022	Basal transcription factors	1/1030	44/7206	0.0160789266956
ko05144	Malaria	1/1030	45/7206	0.0164526223908
ko00071	Fatty acid degradation	1/1030	45/7206	0.0164526223908
ko04964	Proximal tubule bicarbonate reclamation	9/1030	29/7206	0.0164574245487
ko04140	Autophagy - animal	13/1030	164/7206	0.0172600875486
ko00280	Valine, leucine and isoleucine degradation	2/1030	54/7206	0.0189149301182
ko04657	IL-17 signaling pathway	5/1030	87/7206	0.0197639646409
ko01524	Platinum drug resistance	4/1030	76/7206	0.0202116710659
ko04015	Rap1 signaling pathway	53/1030	278/7206	0.0230983818183
ko00983	Drug metabolism - other enzymes	1/1030	42/7206	0.0242788422627
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1030	26/7206	0.0244661931899
ko00310	Lysine degradation	4/1030	73/7206	0.0279215351365
ko04622	RIG-I-like receptor signaling pathway	3/1030	62/7206	0.0281963118244
ko00600	Sphingolipid metabolism	3/1030	63/7206	0.028421141245
ko04350	TGF-beta signaling pathway	7/1030	103/7206	0.0319419433231
ko05166	HTLV-I infection	29/1030	292/7206	0.0323718216067
ko04668	TNF signaling pathway	9/1030	120/7206	0.0342053253154
ko05418	Fluid shear stress and atherosclerosis	15/1030	173/7206	0.0358399240905
ko04138	Autophagy - yeast	5/1030	81/7206	0.0365462243681
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1030	40/7206	0.0371737911076
ko04137	Mitophagy - animal	5/1030	82/7206	0.0371876353261
ko03320	PPAR signaling pathway	4/1030	69/7206	0.0383673214008
ko04371	Apelin signaling pathway	35/1030	177/7206	0.0388462111663
ko04973	Carbohydrate digestion and absorption	11/1030	42/7206	0.0423691524124
ko05133	Pertussis	6/1030	87/7206	0.0451448447275
ko04142	Lysosome	13/1030	151/7206	0.0451640801422
ko05222	Small cell lung cancer	6/1030	89/7206	0.0458266834424
ko04391	Hippo signaling pathway - fly	20/1030	90/7206	0.0467850363532