ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 141/967 423/7206 1.6312290234e-27 ko04721 Synaptic vesicle cycle 52/967 80/7206 8.85566679368e-27 ko04724 Glutamatergic synapse 71/967 152/7206 6.72821639996e-24 ko05033 Nicotine addiction 40/967 56/7206 3.04090480287e-23 ko04727 GABAergic synapse 52/967 110/7206 4.49863453052e-18 ko05032 Morphine addiction 51/967 110/7206 2.69495282695e-17 ko04713 Circadian entrainment 57/967 136/7206 1.1166413156e-16 ko04728 Dopaminergic synapse 68/967 185/7206 4.17548552802e-16 ko04725 Cholinergic synapse 59/967 160/7206 3.39133910045e-14 ko04723 Retrograde endocannabinoid signaling 60/967 175/7206 8.44703926824e-13 ko04024 cAMP signaling pathway 78/967 279/7206 6.63049241726e-11 ko04742 Taste transduction 29/967 61/7206 1.01787337886e-10 ko04911 Insulin secretion 41/967 117/7206 1.79491257211e-09 ko04744 Phototransduction 20/967 36/7206 2.59225114639e-09 ko04360 Axon guidance 64/967 233/7206 7.05526324236e-09 ko04726 Serotonergic synapse 44/967 137/7206 1.23085411946e-08 ko04261 Adrenergic signaling in cardiomyocytes 58/967 205/7206 1.4871807645e-08 ko05031 Amphetamine addiction 33/967 91/7206 2.66941340171e-08 ko03040 Spliceosome 1/967 145/7206 3.86029667115e-08 ko04966 Collecting duct acid secretion 15/967 26/7206 1.35313882039e-07 ko05030 Cocaine addiction 27/967 73/7206 3.10812620481e-07 ko05168 Herpes simplex infection 5/967 182/7206 1.28547818009e-06 ko04720 Long-term potentiation 32/967 99/7206 1.47047692429e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 26/967 74/7206 1.6153125988e-06 ko04921 Oxytocin signaling pathway 53/967 209/7206 2.49383158894e-06 ko04970 Salivary secretion 30/967 95/7206 4.40489814881e-06 ko04060 Cytokine-cytokine receptor interaction 7/967 191/7206 7.50769394454e-06 ko03013 RNA transport 5/967 166/7206 7.95423517909e-06 ko05203 Viral carcinogenesis 15/967 277/7206 1.94203577502e-05 ko05164 Influenza A 6/967 167/7206 2.68732085517e-05 ko04120 Ubiquitin mediated proteolysis 4/967 138/7206 3.92111145063e-05 ko05110 Vibrio cholerae infection 21/967 63/7206 4.01212308785e-05 ko04260 Cardiac muscle contraction 28/967 98/7206 6.68814325572e-05 ko04621 NOD-like receptor signaling pathway 6/967 157/7206 7.63738474805e-05 ko04010 MAPK signaling pathway 68/967 321/7206 0.000102886395659 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/967 14/7206 0.000145025593308 ko04961 Endocrine and other factor-regulated calcium reabsorption 19/967 59/7206 0.000156244791178 ko04141 Protein processing in endoplasmic reticulum 9/967 184/7206 0.000175434766699 ko04514 Cell adhesion molecules (CAMs) 33/967 130/7206 0.000217167751307 ko03008 Ribosome biogenesis in eukaryotes 1/967 79/7206 0.000328627146447 ko05322 Systemic lupus erythematosus 7/967 151/7206 0.000622254628293 ko04915 Estrogen signaling pathway 32/967 131/7206 0.000633600713709 ko04925 Aldosterone synthesis and secretion 27/967 105/7206 0.000715393796637 ko04020 Calcium signaling pathway 55/967 265/7206 0.000869106158719 ko04540 Gap junction 31/967 128/7206 0.0008975983119 ko05120 Epithelial cell signaling in Helicobacter pylori infection 24/967 92/7206 0.00100313433584 ko05162 Measles 5/967 120/7206 0.00108519873608 ko04022 cGMP-PKG signaling pathway 46/967 216/7206 0.00110704623888 ko04924 Renin secretion 23/967 86/7206 0.00111488211157 ko04064 NF-kappa B signaling pathway 3/967 96/7206 0.0012652520371 ko04971 Gastric acid secretion 25/967 98/7206 0.00139240148741 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/967 79/7206 0.00144561624581 ko04740 Olfactory transduction 21/967 80/7206 0.00238915931591 ko04146 Peroxisome 3/967 89/7206 0.00255490358925 ko04014 Ras signaling pathway 55/967 279/7206 0.00295548440108 ko04730 Long-term depression 20/967 78/7206 0.00375683704387 ko00240 Pyrimidine metabolism 5/967 110/7206 0.00426372164471 ko04972 Pancreatic secretion 26/967 111/7206 0.00442291333185 ko04976 Bile secretion 20/967 80/7206 0.00452689936166 ko05205 Proteoglycans in cancer 21/967 271/7206 0.00464159298609 ko05321 Inflammatory bowel disease (IBD) 1/967 56/7206 0.00509025994848 ko01200 Carbon metabolism 7/967 128/7206 0.00556620266248 ko05169 Epstein-Barr virus infection 15/967 206/7206 0.00679388963288 ko04145 Phagosome 34/967 162/7206 0.0069394529248 ko04110 Cell cycle 9/967 145/7206 0.0091235104007 ko04640 Hematopoietic cell lineage 2/967 64/7206 0.00938896181907 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 6/967 15/7206 0.00978526477733 ko04962 Vasopressin-regulated water reabsorption 15/967 58/7206 0.0103204421799 ko05140 Leishmaniasis 3/967 75/7206 0.0104181648727 ko05414 Dilated cardiomyopathy 25/967 112/7206 0.0109738213098 ko04964 Proximal tubule bicarbonate reclamation 9/967 29/7206 0.0110647498974 ko00330 Arginine and proline metabolism 2/967 61/7206 0.0135371447372 ko04217 Necroptosis 13/967 178/7206 0.0138290720158 ko04214 Apoptosis - fly 3/967 72/7206 0.0146936003055 ko03018 RNA degradation 4/967 84/7206 0.015025575241 ko00620 Pyruvate metabolism 1/967 46/7206 0.0165753958544 ko03420 Nucleotide excision repair 1/967 46/7206 0.0165753958544 ko05145 Toxoplasmosis 8/967 126/7206 0.0169045421355 ko05204 Chemical carcinogenesis 1/967 48/7206 0.017027566286 ko05323 Rheumatoid arthritis 20/967 89/7206 0.0177919139381 ko04371 Apelin signaling pathway 35/967 177/7206 0.0183185440201 ko04391 Hippo signaling pathway - fly 20/967 90/7206 0.0189405257279 ko04072 Phospholipase D signaling pathway 38/967 197/7206 0.0191963346336 ko03022 Basal transcription factors 1/967 44/7206 0.0245793985163 ko05144 Malaria 1/967 45/7206 0.0251949184099 ko00071 Fatty acid degradation 1/967 45/7206 0.0251949184099 ko04626 Plant-pathogen interaction 6/967 18/7206 0.0254909472283 ko05034 Alcoholism 44/967 238/7206 0.0255955338428 ko05146 Amoebiasis 6/967 99/7206 0.0259116354382 ko04930 Type II diabetes mellitus 13/967 54/7206 0.0274628192562 ko00480 Glutathione metabolism 2/967 55/7206 0.027911032022 ko04612 Antigen processing and presentation 4/967 77/7206 0.0286161479415 ko04745 Phototransduction - fly 10/967 38/7206 0.0289827574053 ko04015 Rap1 signaling pathway 50/967 278/7206 0.0307094739463 ko04750 Inflammatory mediator regulation of TRP channels 25/967 122/7206 0.0307422930949 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/967 182/7206 0.0362269803101 ko00140 Steroid hormone biosynthesis 1/967 41/7206 0.0362754145547 ko04140 Autophagy - animal 13/967 164/7206 0.0365009209113 ko00983 Drug metabolism - other enzymes 1/967 42/7206 0.0372052253402 ko04115 p53 signaling pathway 4/967 74/7206 0.0392472279873 ko00590 Arachidonic acid metabolism 2/967 52/7206 0.0398917647469 ko00561 Glycerolipid metabolism 3/967 63/7206 0.0404179246509 ko00600 Sphingolipid metabolism 3/967 63/7206 0.0404179246509 ko05161 Hepatitis B 14/967 173/7206 0.0412079892974 ko00280 Valine, leucine and isoleucine degradation 2/967 54/7206 0.0416023033289 ko00190 Oxidative phosphorylation 25/967 127/7206 0.0474754531003 ko04950 Maturity onset diabetes of the young 8/967 29/7206 0.0480075466813