ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 47/368 191/7206 1.96652258425e-20 ko04650 Natural killer cell mediated cytotoxicity 28/368 97/7206 1.78978893234e-14 ko05164 Influenza A 35/368 167/7206 3.50931235334e-13 ko04380 Osteoclast differentiation 31/368 134/7206 5.161225897e-13 ko05168 Herpes simplex infection 36/368 182/7206 9.97867034225e-13 ko05321 Inflammatory bowel disease (IBD) 20/368 56/7206 1.26757500805e-12 ko05340 Primary immunodeficiency 15/368 30/7206 2.43748522525e-12 ko05140 Leishmaniasis 22/368 75/7206 8.74087817826e-12 ko05152 Tuberculosis 35/368 187/7206 1.11901610232e-11 ko04217 Necroptosis 34/368 178/7206 1.24098455199e-11 ko05330 Allograft rejection 13/368 24/7206 1.95384084902e-11 ko05145 Toxoplasmosis 28/368 126/7206 2.04513674565e-11 ko04621 NOD-like receptor signaling pathway 31/368 157/7206 4.30212890391e-11 ko05162 Measles 26/368 120/7206 1.99517523681e-10 ko04064 NF-kappa B signaling pathway 23/368 96/7206 2.72472734491e-10 ko05320 Autoimmune thyroid disease 13/368 29/7206 4.20303111519e-10 ko04612 Antigen processing and presentation 20/368 77/7206 8.80965389533e-10 ko04660 T cell receptor signaling pathway 25/368 124/7206 2.23950338539e-09 ko05332 Graft-versus-host disease 10/368 18/7206 3.24410464235e-09 ko04620 Toll-like receptor signaling pathway 22/368 100/7206 3.80927190221e-09 ko04630 Jak-STAT signaling pathway 25/368 132/7206 8.66969965507e-09 ko05150 Staphylococcus aureus infection 13/368 36/7206 1.03141722023e-08 ko04659 Th17 cell differentiation 22/368 106/7206 1.20396668202e-08 ko04672 Intestinal immune network for IgA production 12/368 37/7206 1.52858807097e-07 ko04658 Th1 and Th2 cell differentiation 19/368 96/7206 2.69292208124e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/368 191/7206 3.48742375104e-07 ko04640 Hematopoietic cell lineage 15/368 64/7206 5.07179567938e-07 ko05310 Asthma 8/368 17/7206 6.95062962969e-07 ko05144 Malaria 12/368 45/7206 1.63587981708e-06 ko04610 Complement and coagulation cascades 16/368 79/7206 1.73578875309e-06 ko04622 RIG-I-like receptor signaling pathway 14/368 62/7206 1.97979740937e-06 ko05142 Chagas disease (American trypanosomiasis) 21/368 130/7206 2.17849053817e-06 ko04940 Type I diabetes mellitus 10/368 32/7206 2.50893404251e-06 ko04062 Chemokine signaling pathway 27/368 201/7206 3.24182731562e-06 ko05323 Rheumatoid arthritis 16/368 89/7206 8.88417713177e-06 ko05161 Hepatitis B 23/368 173/7206 2.08645997376e-05 ko04145 Phagosome 22/368 162/7206 2.25650016174e-05 ko05133 Pertussis 15/368 87/7206 2.84982988473e-05 ko04662 B cell receptor signaling pathway 15/368 88/7206 3.27848606641e-05 ko04668 TNF signaling pathway 17/368 120/7206 0.00011377301947 ko05160 Hepatitis C 19/368 153/7206 0.000271008922362 ko03050 Proteasome 10/368 54/7206 0.000339853790822 ko00120 Primary bile acid biosynthesis 6/368 20/7206 0.000358175680034 ko04210 Apoptosis 21/368 180/7206 0.000384409332191 ko04623 Cytosolic DNA-sensing pathway 8/368 41/7206 0.00092801144865 ko05132 Salmonella infection 13/368 98/7206 0.0013443425564 ko04310 Wnt signaling pathway 1/368 181/7206 0.00161162120503 ko04664 Fc epsilon RI signaling pathway 11/368 77/7206 0.00169685560465 ko04611 Platelet activation 18/368 163/7206 0.00175292972014 ko04670 Leukocyte transendothelial migration 17/368 151/7206 0.00204585901182 ko04514 Cell adhesion molecules (CAMs) 15/368 130/7206 0.00350150606514 ko00590 Arachidonic acid metabolism 8/368 52/7206 0.0044800847406 ko04657 IL-17 signaling pathway 11/368 87/7206 0.00451051293177 ko05143 African trypanosomiasis 6/368 32/7206 0.00498289468749 ko04390 Hippo signaling pathway 2/368 188/7206 0.00628460764343 ko05416 Viral myocarditis 8/368 55/7206 0.00634693493904 ko03040 Spliceosome 1/368 145/7206 0.00699143310592 ko04110 Cell cycle 1/368 145/7206 0.00699143310592 ko04137 Mitophagy - animal 10/368 82/7206 0.00854793470577 ko04723 Retrograde endocannabinoid signaling 2/368 175/7206 0.00873107012997 ko05034 Alcoholism 4/368 238/7206 0.0101755106728 ko04666 Fc gamma R-mediated phagocytosis 13/368 122/7206 0.0107031429703 ko05224 Breast cancer 2/368 174/7206 0.0129219534736 ko03010 Ribosome 1/368 129/7206 0.0146929332521 ko00980 Metabolism of xenobiotics by cytochrome P450 6/368 40/7206 0.0149874005903 ko05146 Amoebiasis 11/368 99/7206 0.0171619059216 ko00051 Fructose and mannose metabolism 6/368 42/7206 0.0188119940243 ko05169 Epstein-Barr virus infection 18/368 206/7206 0.0233415897505 ko04728 Dopaminergic synapse 3/368 185/7206 0.0260916587294 ko04911 Insulin secretion 1/368 117/7206 0.0311922767944 ko04360 Axon guidance 5/368 233/7206 0.0333498717965 ko05204 Chemical carcinogenesis 6/368 48/7206 0.0341355308806 ko05206 MicroRNAs in cancer 3/368 177/7206 0.0359030042466 ko05131 Shigellosis 9/368 82/7206 0.0365627554691 ko00982 Drug metabolism - cytochrome P450 5/368 37/7206 0.0384019950375 ko04012 ErbB signaling pathway 1/368 109/7206 0.0448411602696 ko04972 Pancreatic secretion 1/368 111/7206 0.0458497468446 ko04550 Signaling pathways regulating pluripotency of stem cells 3/368 165/7206 0.0485376344099