ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 115/704 423/7206 2.15468382009e-26 ko04721 Synaptic vesicle cycle 45/704 80/7206 2.0266016853e-25 ko04724 Glutamatergic synapse 60/704 152/7206 5.62952114278e-23 ko05033 Nicotine addiction 35/704 56/7206 3.7161167542e-22 ko04728 Dopaminergic synapse 60/704 185/7206 5.26687675663e-18 ko04727 GABAergic synapse 44/704 110/7206 2.19810707298e-17 ko05032 Morphine addiction 42/704 110/7206 8.76429021415e-16 ko04713 Circadian entrainment 46/704 136/7206 7.8793054042e-15 ko04723 Retrograde endocannabinoid signaling 52/704 175/7206 5.50016345959e-14 ko04725 Cholinergic synapse 47/704 160/7206 1.49828091582e-12 ko04911 Insulin secretion 37/704 117/7206 3.51573351576e-11 ko04024 cAMP signaling pathway 62/704 279/7206 3.49470900027e-10 ko04744 Phototransduction 18/704 36/7206 8.91164678489e-10 ko04726 Serotonergic synapse 38/704 137/7206 1.36719181549e-09 ko04966 Collecting duct acid secretion 15/704 26/7206 1.69143251972e-09 ko05031 Amphetamine addiction 29/704 91/7206 3.94958291542e-09 ko04921 Oxytocin signaling pathway 47/704 209/7206 3.55168820117e-08 ko04720 Long-term potentiation 28/704 99/7206 1.31975502114e-07 ko04020 Calcium signaling pathway 53/704 265/7206 2.55282239261e-07 ko05030 Cocaine addiction 22/704 73/7206 8.96223146202e-07 ko04970 Salivary secretion 25/704 95/7206 2.68985320328e-06 ko04261 Adrenergic signaling in cardiomyocytes 42/704 205/7206 3.32126946821e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 21/704 74/7206 4.64074856006e-06 ko05110 Vibrio cholerae infection 18/704 63/7206 1.9996589038e-05 ko05322 Systemic lupus erythematosus 2/704 151/7206 4.12230984539e-05 ko04971 Gastric acid secretion 23/704 98/7206 5.00351925019e-05 ko03040 Spliceosome 2/704 145/7206 9.25090318924e-05 ko05203 Viral carcinogenesis 10/704 277/7206 0.000118704427942 ko04120 Ubiquitin mediated proteolysis 2/704 138/7206 0.000128978892819 ko04730 Long-term depression 19/704 78/7206 0.000131557790488 ko04972 Pancreatic secretion 24/704 111/7206 0.000148859902572 ko04010 MAPK signaling pathway 52/704 321/7206 0.000225750106481 ko04964 Proximal tubule bicarbonate reclamation 10/704 29/7206 0.000265110077069 ko04022 cGMP-PKG signaling pathway 38/704 216/7206 0.000271901600414 ko05164 Influenza A 4/704 167/7206 0.000305160112585 ko05168 Herpes simplex infection 5/704 182/7206 0.000346089845101 ko05120 Epithelial cell signaling in Helicobacter pylori infection 20/704 92/7206 0.000528045423094 ko04510 Focal adhesion 9/704 240/7206 0.000553509435902 ko04540 Gap junction 25/704 128/7206 0.000729246599653 ko04745 Phototransduction - fly 11/704 38/7206 0.000730646456042 ko04060 Cytokine-cytokine receptor interaction 6/704 191/7206 0.000732941678343 ko05162 Measles 2/704 120/7206 0.000876294169909 ko04626 Plant-pathogen interaction 7/704 18/7206 0.00100098412737 ko04070 Phosphatidylinositol signaling system 22/704 112/7206 0.00116659728399 ko04925 Aldosterone synthesis and secretion 21/704 105/7206 0.00129623231647 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/704 59/7206 0.0013012528844 ko03013 RNA transport 5/704 166/7206 0.0013228864506 ko05205 Proteoglycans in cancer 12/704 271/7206 0.00160492968786 ko04742 Taste transduction 14/704 61/7206 0.00183334042715 ko04621 NOD-like receptor signaling pathway 5/704 157/7206 0.00253464156836 ko05323 Rheumatoid arthritis 18/704 89/7206 0.00314458100371 ko04141 Protein processing in endoplasmic reticulum 7/704 184/7206 0.00352417444918 ko04514 Cell adhesion molecules (CAMs) 23/704 130/7206 0.00424693552227 ko04924 Renin secretion 17/704 86/7206 0.00492341468955 ko04612 Antigen processing and presentation 1/704 77/7206 0.00598429640244 ko04610 Complement and coagulation cascades 1/704 79/7206 0.00626788850173 ko03008 Ribosome biogenesis in eukaryotes 1/704 79/7206 0.00626788850173 ko00190 Oxidative phosphorylation 22/704 127/7206 0.00644240889698 ko04072 Phospholipase D signaling pathway 31/704 197/7206 0.00702793874076 ko00910 Nitrogen metabolism 6/704 19/7206 0.00759269959781 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/704 14/7206 0.00829891508926 ko04750 Inflammatory mediator regulation of TRP channels 21/704 122/7206 0.00854874751484 ko04260 Cardiac muscle contraction 18/704 98/7206 0.00879796477296 ko05166 HTLV-I infection 16/704 292/7206 0.00882017820891 ko05010 Alzheimer's disease 31/704 202/7206 0.0109731699288 ko05169 Epstein-Barr virus infection 10/704 206/7206 0.0122183762777 ko04014 Ras signaling pathway 40/704 279/7206 0.0130835452994 ko05034 Alcoholism 35/704 238/7206 0.0139676222597 ko04360 Axon guidance 34/704 233/7206 0.0177582207185 ko05161 Hepatitis B 8/704 173/7206 0.0188778973086 ko04145 Phagosome 25/704 162/7206 0.0217070641998 ko04064 NF-kappa B signaling pathway 3/704 96/7206 0.0232087269637 ko05215 Prostate cancer 4/704 111/7206 0.0232285963037 ko04670 Leukocyte transendothelial migration 7/704 151/7206 0.0266974873449 ko00330 Arginine and proline metabolism 1/704 61/7206 0.0276837470833 ko05140 Leishmaniasis 2/704 75/7206 0.0309621350745 ko01524 Platinum drug resistance 2/704 76/7206 0.031075895354 ko04611 Platelet activation 8/704 163/7206 0.0321744659869 ko04630 Jak-STAT signaling pathway 6/704 132/7206 0.0380079557629 ko04016 MAPK signaling pathway - plant 5/704 20/7206 0.0393712108307 ko00480 Glutathione metabolism 1/704 55/7206 0.0397389924813 ko05321 Inflammatory bowel disease (IBD) 1/704 56/7206 0.0398964068886 ko04114 Oocyte meiosis 21/704 139/7206 0.0419515005642 ko04810 Regulation of actin cytoskeleton 16/704 264/7206 0.0438439964585 ko04146 Peroxisome 3/704 89/7206 0.045369313075