ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1300	423/7206	7.66501790597e-52
ko04724	Glutamatergic synapse	96/1300	152/7206	1.2778319838e-35
ko05033	Nicotine addiction	51/1300	56/7206	7.73356625428e-33
ko05032	Morphine addiction	75/1300	110/7206	2.53757270239e-31
ko04713	Circadian entrainment	83/1300	136/7206	2.39867267213e-29
ko04727	GABAergic synapse	70/1300	110/7206	1.70083931358e-26
ko04728	Dopaminergic synapse	90/1300	185/7206	5.29588734367e-22
ko04725	Cholinergic synapse	81/1300	160/7206	2.66358716245e-21
ko04024	cAMP signaling pathway	116/1300	279/7206	7.1475691089e-21
ko04721	Synaptic vesicle cycle	52/1300	80/7206	1.36559761882e-20
ko04723	Retrograde endocannabinoid signaling	83/1300	175/7206	1.76212128593e-19
ko04020	Calcium signaling pathway	106/1300	265/7206	1.32361293066e-17
ko04921	Oxytocin signaling pathway	87/1300	209/7206	6.27464880236e-16
ko04911	Insulin secretion	59/1300	117/7206	1.00149317805e-15
ko04742	Taste transduction	38/1300	61/7206	1.72859270759e-14
ko04744	Phototransduction	27/1300	36/7206	1.15642317192e-13
ko04261	Adrenergic signaling in cardiomyocytes	81/1300	205/7206	2.18772646241e-13
ko04726	Serotonergic synapse	61/1300	137/7206	4.43500711155e-13
ko03040	Spliceosome	1/1300	145/7206	1.62223445722e-11
ko05031	Amphetamine addiction	44/1300	91/7206	2.91681868292e-11
ko04720	Long-term potentiation	46/1300	99/7206	5.8520749021e-11
ko04360	Axon guidance	83/1300	233/7206	9.39531700942e-11
ko04970	Salivary secretion	44/1300	95/7206	1.75055668752e-10
ko04022	cGMP-PKG signaling pathway	76/1300	216/7206	1.30760294544e-09
ko05030	Cocaine addiction	35/1300	73/7206	4.16688114009e-09
ko04971	Gastric acid secretion	42/1300	98/7206	1.13078907678e-08
ko04925	Aldosterone synthesis and secretion	43/1300	105/7206	4.61750964538e-08
ko05203	Viral carcinogenesis	19/1300	277/7206	6.64390931044e-08
ko04740	Olfactory transduction	35/1300	80/7206	7.84796720418e-08
ko03013	RNA transport	7/1300	166/7206	1.0938963814e-07
ko05322	Systemic lupus erythematosus	6/1300	151/7206	2.77295578414e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1300	74/7206	1.74477860462e-06
ko04070	Phosphatidylinositol signaling system	41/1300	112/7206	2.60066197636e-06
ko05168	Herpes simplex infection	11/1300	182/7206	3.2035540693e-06
ko04060	Cytokine-cytokine receptor interaction	12/1300	191/7206	3.39303407971e-06
ko04610	Complement and coagulation cascades	1/1300	79/7206	4.78710341224e-06
ko04972	Pancreatic secretion	40/1300	111/7206	4.98136704065e-06
ko04010	MAPK signaling pathway	90/1300	321/7206	7.09761855228e-06
ko04923	Regulation of lipolysis in adipocytes	30/1300	77/7206	1.54715068155e-05
ko04072	Phospholipase D signaling pathway	60/1300	197/7206	1.87814594393e-05
ko04730	Long-term depression	30/1300	78/7206	1.89446585144e-05
ko04371	Apelin signaling pathway	55/1300	177/7206	2.52478549905e-05
ko04924	Renin secretion	32/1300	86/7206	2.52490203541e-05
ko04966	Collecting duct acid secretion	14/1300	26/7206	3.98636242319e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1300	79/7206	4.46027914921e-05
ko05110	Vibrio cholerae infection	25/1300	63/7206	4.67467558493e-05
ko04141	Protein processing in endoplasmic reticulum	14/1300	184/7206	6.0184180696e-05
ko05164	Influenza A	12/1300	167/7206	8.99342582195e-05
ko05414	Dilated cardiomyopathy	37/1300	112/7206	0.000104246676891
ko04540	Gap junction	41/1300	128/7206	0.00010667190459
ko04745	Phototransduction - fly	17/1300	38/7206	0.00012742670166
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1300	59/7206	0.000127713264159
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1300	79/7206	0.000186199251308
ko04621	NOD-like receptor signaling pathway	12/1300	157/7206	0.000310515234414
ko04514	Cell adhesion molecules (CAMs)	40/1300	130/7206	0.000327720413094
ko04976	Bile secretion	28/1300	80/7206	0.000328796849296
ko04014	Ras signaling pathway	74/1300	279/7206	0.000330364536899
ko04064	NF-kappa B signaling pathway	5/1300	96/7206	0.000408771010336
ko04110	Cell cycle	11/1300	145/7206	0.00043081179175
ko05169	Epstein-Barr virus infection	19/1300	206/7206	0.000444621130773
ko04612	Antigen processing and presentation	3/1300	77/7206	0.000457101618664
ko04915	Estrogen signaling pathway	40/1300	131/7206	0.000495139329613
ko05205	Proteoglycans in cancer	28/1300	271/7206	0.000499750396122
ko04711	Circadian rhythm - fly	8/1300	13/7206	0.000597529932112
ko04146	Peroxisome	5/1300	89/7206	0.00118921720006
ko04260	Cardiac muscle contraction	31/1300	98/7206	0.00127229835687
ko05162	Measles	9/1300	120/7206	0.00164951434745
ko03420	Nucleotide excision repair	1/1300	46/7206	0.00176465398423
ko04626	Plant-pathogen interaction	9/1300	18/7206	0.00199919200728
ko05140	Leishmaniasis	4/1300	75/7206	0.00220044667862
ko00480	Glutathione metabolism	2/1300	55/7206	0.00240246698806
ko05321	Inflammatory bowel disease (IBD)	2/1300	56/7206	0.00245663990605
ko03022	Basal transcription factors	1/1300	44/7206	0.00267294398323
ko05144	Malaria	1/1300	45/7206	0.00275082392678
ko00071	Fatty acid degradation	1/1300	45/7206	0.00275082392678
ko04964	Proximal tubule bicarbonate reclamation	12/1300	29/7206	0.00283439139426
ko04912	GnRH signaling pathway	35/1300	122/7206	0.00401468498076
ko04750	Inflammatory mediator regulation of TRP channels	35/1300	122/7206	0.00401468498076
ko00330	Arginine and proline metabolism	3/1300	61/7206	0.00412513078238
ko04622	RIG-I-like receptor signaling pathway	3/1300	62/7206	0.0041759021388
ko04916	Melanogenesis	39/1300	142/7206	0.00550538379599
ko00590	Arachidonic acid metabolism	2/1300	52/7206	0.0055355765753
ko00240	Pyrimidine metabolism	9/1300	110/7206	0.00553717859918
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1300	40/7206	0.00618704152772
ko03018	RNA degradation	6/1300	84/7206	0.00631818499865
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1300	14/7206	0.00643948502829
ko03320	PPAR signaling pathway	4/1300	69/7206	0.00660907167354
ko04918	Thyroid hormone synthesis	26/1300	86/7206	0.00664662744633
ko05161	Hepatitis B	18/1300	173/7206	0.0066969996539
ko04270	Vascular smooth muscle contraction	41/1300	154/7206	0.00774623904205
ko04710	Circadian rhythm	15/1300	43/7206	0.00818580406439
ko00310	Lysine degradation	5/1300	73/7206	0.00894135321982
ko04115	p53 signaling pathway	5/1300	74/7206	0.00902613724782
ko00982	Drug metabolism - cytochrome P450	1/1300	37/7206	0.00923177711031
ko03410	Base excision repair	1/1300	38/7206	0.00944802583534
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1300	182/7206	0.0108827542874
ko00280	Valine, leucine and isoleucine degradation	3/1300	54/7206	0.0122874429079
ko04640	Hematopoietic cell lineage	4/1300	64/7206	0.0130192108683
ko04120	Ubiquitin mediated proteolysis	14/1300	138/7206	0.0135247425377
ko04015	Rap1 signaling pathway	66/1300	278/7206	0.0136388177246
ko00500	Starch and sucrose metabolism	1/1300	35/7206	0.0139423146943
ko05231	Choline metabolism in cancer	35/1300	134/7206	0.0171597723996
ko00562	Inositol phosphate metabolism	25/1300	89/7206	0.0177902143419
ko04930	Type II diabetes mellitus	17/1300	54/7206	0.018965851545
ko05131	Shigellosis	7/1300	82/7206	0.020722148652
ko04630	Jak-STAT signaling pathway	14/1300	132/7206	0.0222818703858
ko04658	Th1 and Th2 cell differentiation	9/1300	96/7206	0.0230328754058
ko00380	Tryptophan metabolism	3/1300	50/7206	0.0251962477278
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1300	100/7206	0.0252081749751
ko04922	Glucagon signaling pathway	33/1300	128/7206	0.0270253240831
ko04722	Neurotrophin signaling pathway	40/1300	160/7206	0.0283135024668
ko00230	Purine metabolism	47/1300	194/7206	0.029002269303
ko04217	Necroptosis	21/1300	178/7206	0.0294121895969
ko04214	Apoptosis - fly	6/1300	72/7206	0.0302682581745
ko05340	Primary immunodeficiency	1/1300	30/7206	0.0313626100486
ko04062	Chemokine signaling pathway	48/1300	201/7206	0.0323393529644
ko04114	Oocyte meiosis	35/1300	139/7206	0.0336951952164
ko04657	IL-17 signaling pathway	8/1300	87/7206	0.0340925610555
ko05133	Pertussis	8/1300	87/7206	0.0340925610555
ko04620	Toll-like receptor signaling pathway	10/1300	100/7206	0.0355205662857
ko05204	Chemical carcinogenesis	3/1300	48/7206	0.0360410219713
ko00260	Glycine, serine and threonine metabolism	3/1300	48/7206	0.0360410219713
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1300	26/7206	0.0383763694331
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1300	15/7206	0.0389231130201
ko05320	Autoimmune thyroid disease	1/1300	29/7206	0.0485356657894