ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	167/818	423/7206	1.08142196569e-54
ko05033	Nicotine addiction	48/818	56/7206	7.33808069399e-38
ko04724	Glutamatergic synapse	80/818	152/7206	8.86551266598e-37
ko04727	GABAergic synapse	57/818	110/7206	6.01251531334e-26
ko05032	Morphine addiction	57/818	110/7206	6.01251531334e-26
ko04713	Circadian entrainment	61/818	136/7206	2.16633570107e-23
ko04728	Dopaminergic synapse	71/818	185/7206	3.54009819659e-22
ko04723	Retrograde endocannabinoid signaling	67/818	175/7206	6.57892778105e-21
ko04024	cAMP signaling pathway	85/818	279/7206	9.63630411996e-19
ko04725	Cholinergic synapse	57/818	160/7206	2.9400047046e-16
ko04911	Insulin secretion	47/818	117/7206	5.99947896647e-16
ko04742	Taste transduction	32/818	61/7206	2.81080958598e-15
ko04020	Calcium signaling pathway	76/818	265/7206	3.13968791855e-15
ko04721	Synaptic vesicle cycle	37/818	80/7206	3.60659090828e-15
ko04726	Serotonergic synapse	50/818	137/7206	6.90903765267e-15
ko04921	Oxytocin signaling pathway	62/818	209/7206	2.44651180756e-13
ko05031	Amphetamine addiction	37/818	91/7206	5.18106990448e-13
ko04720	Long-term potentiation	38/818	99/7206	2.12790976217e-12
ko04261	Adrenergic signaling in cardiomyocytes	56/818	205/7206	1.48530390631e-10
ko05030	Cocaine addiction	28/818	73/7206	1.80133675129e-09
ko04060	Cytokine-cytokine receptor interaction	1/818	191/7206	4.12834821756e-09
ko05014	Amyotrophic lateral sclerosis (ALS)	27/818	74/7206	1.25509722e-08
ko04744	Phototransduction	17/818	36/7206	7.77424486933e-08
ko04970	Salivary secretion	30/818	95/7206	8.8752146196e-08
ko04010	MAPK signaling pathway	68/818	321/7206	1.94385580223e-07
ko04925	Aldosterone synthesis and secretion	31/818	105/7206	2.9844447727e-07
ko04971	Gastric acid secretion	29/818	98/7206	6.82297006575e-07
ko03040	Spliceosome	1/818	145/7206	8.59756548505e-07
ko05203	Viral carcinogenesis	9/818	277/7206	1.02068755509e-06
ko04972	Pancreatic secretion	30/818	111/7206	4.97967961057e-06
ko05168	Herpes simplex infection	4/818	182/7206	7.67030284755e-06
ko04730	Long-term depression	23/818	78/7206	1.03369233714e-05
ko04740	Olfactory transduction	23/818	80/7206	1.63854572485e-05
ko04260	Cardiac muscle contraction	26/818	98/7206	2.95479182258e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	22/818	79/7206	4.29330631835e-05
ko04022	cGMP-PKG signaling pathway	45/818	216/7206	4.35370535428e-05
ko04072	Phospholipase D signaling pathway	42/818	197/7206	5.03160290296e-05
ko04070	Phosphatidylinositol signaling system	28/818	112/7206	5.57274529713e-05
ko04350	TGF-beta signaling pathway	1/818	103/7206	0.000111054769954
ko05322	Systemic lupus erythematosus	4/818	151/7206	0.000135719323737
ko05164	Influenza A	5/818	167/7206	0.000165430511039
ko04514	Cell adhesion molecules (CAMs)	29/818	130/7206	0.000367229751256
ko04924	Renin secretion	21/818	86/7206	0.000503493700621
ko05169	Epstein-Barr virus infection	9/818	206/7206	0.000510908191348
ko04540	Gap junction	28/818	128/7206	0.000583983322705
ko04360	Axon guidance	43/818	233/7206	0.00106062563133
ko04621	NOD-like receptor signaling pathway	6/818	157/7206	0.00128956362136
ko04141	Protein processing in endoplasmic reticulum	8/818	184/7206	0.00131475808244
ko04120	Ubiquitin mediated proteolysis	5/818	138/7206	0.00169478971151
ko04612	Antigen processing and presentation	1/818	77/7206	0.00173091503175
ko03013	RNA transport	7/818	166/7206	0.00178240442033
ko04610	Complement and coagulation cascades	1/818	79/7206	0.0018398194294
ko04915	Estrogen signaling pathway	27/818	131/7206	0.00192075273961
ko00240	Pyrimidine metabolism	3/818	110/7206	0.0020445727463
ko05205	Proteoglycans in cancer	16/818	271/7206	0.00241828635688
ko05162	Measles	4/818	120/7206	0.00321108206231
ko04630	Jak-STAT signaling pathway	5/818	132/7206	0.00328282948875
ko04110	Cell cycle	6/818	145/7206	0.0033248176985
ko04146	Peroxisome	2/818	89/7206	0.00354080012348
ko05414	Dilated cardiomyopathy	23/818	112/7206	0.00398583730846
ko04550	Signaling pathways regulating pluripotency of stem cells	8/818	165/7206	0.00584952717404
ko00562	Inositol phosphate metabolism	19/818	89/7206	0.00615885993591
ko04966	Collecting duct acid secretion	8/818	26/7206	0.00641998637516
ko05034	Alcoholism	41/818	238/7206	0.00652790588215
ko03008	Ribosome biogenesis in eukaryotes	2/818	79/7206	0.00708753106844
ko04745	Phototransduction - fly	10/818	38/7206	0.00817988606041
ko04330	Notch signaling pathway	1/818	62/7206	0.0082118529658
ko04640	Hematopoietic cell lineage	1/818	64/7206	0.00849262375069
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/818	182/7206	0.00889777402755
ko05410	Hypertrophic cardiomyopathy (HCM)	20/818	100/7206	0.0102599714797
ko05166	HTLV-I infection	20/818	292/7206	0.0108801343675
ko01212	Fatty acid metabolism	1/818	60/7206	0.0123486179669
ko05231	Choline metabolism in cancer	25/818	134/7206	0.0124046331932
ko04140	Autophagy - animal	9/818	164/7206	0.0126300415643
ko04964	Proximal tubule bicarbonate reclamation	8/818	29/7206	0.0129810608287
ko04912	GnRH signaling pathway	23/818	122/7206	0.0134999560472
ko04750	Inflammatory mediator regulation of TRP channels	23/818	122/7206	0.0134999560472
ko04142	Lysosome	8/818	151/7206	0.013595175441
ko04214	Apoptosis - fly	2/818	72/7206	0.0145738626913
ko00310	Lysine degradation	2/818	73/7206	0.0146603687075
ko04014	Ras signaling pathway	45/818	279/7206	0.0156114542597
ko04930	Type II diabetes mellitus	12/818	54/7206	0.017471143029
ko00480	Glutathione metabolism	1/818	55/7206	0.017776238
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/818	59/7206	0.0202034580282
ko05161	Hepatitis B	10/818	173/7206	0.020234957547
ko04976	Bile secretion	16/818	80/7206	0.020332414918
ko03320	PPAR signaling pathway	2/818	69/7206	0.0208727218488
ko04371	Apelin signaling pathway	30/818	177/7206	0.0222232504481
ko04064	NF-kappa B signaling pathway	4/818	96/7206	0.0222527131558
ko03018	RNA degradation	3/818	84/7206	0.0226075899958
ko04973	Carbohydrate digestion and absorption	10/818	42/7206	0.0230375364993
ko05202	Transcriptional misregulation in cancer	12/818	188/7206	0.0266489812336
ko04510	Focal adhesion	17/818	240/7206	0.0376470322283
ko05016	Huntington's disease	15/818	215/7206	0.0380099018245
ko05219	Bladder cancer	1/818	48/7206	0.0382204074126
ko00512	Mucin type O-glycan biosynthesis	7/818	29/7206	0.0395950018735
ko05222	Small cell lung cancer	4/818	89/7206	0.0418040083878
ko05140	Leishmaniasis	3/818	75/7206	0.0427495958454
ko04210	Apoptosis	12/818	180/7206	0.0429829939289
ko00600	Sphingolipid metabolism	2/818	63/7206	0.0430037545292
ko01524	Platinum drug resistance	3/818	76/7206	0.0432241563851
ko04626	Plant-pathogen interaction	5/818	18/7206	0.0453358670559
ko05200	Pathways in cancer	42/818	492/7206	0.0464161357046
ko05215	Prostate cancer	6/818	111/7206	0.0486989737474