ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 164/914 423/7206 2.59929034684e-45 ko05033 Nicotine addiction 41/914 56/7206 1.87494311256e-25 ko04724 Glutamatergic synapse 67/914 152/7206 2.94834421757e-22 ko04728 Dopaminergic synapse 71/914 185/7206 2.37491747047e-19 ko04721 Synaptic vesicle cycle 42/914 80/7206 7.42107078705e-18 ko05032 Morphine addiction 49/914 110/7206 8.41071874704e-17 ko04727 GABAergic synapse 46/914 110/7206 1.41402329566e-14 ko04713 Circadian entrainment 51/914 136/7206 9.65025178236e-14 ko04725 Cholinergic synapse 56/914 160/7206 1.75229964292e-13 ko04024 cAMP signaling pathway 79/914 279/7206 1.12643918771e-12 ko04723 Retrograde endocannabinoid signaling 55/914 175/7206 3.91610975978e-11 ko04020 Calcium signaling pathway 71/914 265/7206 3.35905303449e-10 ko04742 Taste transduction 27/914 61/7206 9.28171824928e-10 ko04911 Insulin secretion 40/914 117/7206 1.21078286556e-09 ko04726 Serotonergic synapse 44/914 137/7206 1.71809578892e-09 ko04360 Axon guidance 62/914 233/7206 5.12045790897e-09 ko05203 Viral carcinogenesis 8/914 277/7206 1.04027336504e-08 ko05031 Amphetamine addiction 32/914 91/7206 2.58700952095e-08 ko04261 Adrenergic signaling in cardiomyocytes 55/914 205/7206 2.75185542079e-08 ko03040 Spliceosome 1/914 145/7206 9.05364114865e-08 ko05030 Cocaine addiction 26/914 73/7206 3.95570845701e-07 ko04921 Oxytocin signaling pathway 53/914 209/7206 4.16535897198e-07 ko04060 Cytokine-cytokine receptor interaction 5/914 191/7206 1.33172746321e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 25/914 74/7206 2.0436420716e-06 ko05168 Herpes simplex infection 5/914 182/7206 4.11421334579e-06 ko04720 Long-term potentiation 29/914 99/7206 9.61292397252e-06 ko04514 Cell adhesion molecules (CAMs) 35/914 130/7206 1.19294737626e-05 ko04970 Salivary secretion 28/914 95/7206 1.27039237351e-05 ko04010 MAPK signaling pathway 68/914 321/7206 1.46247285655e-05 ko04120 Ubiquitin mediated proteolysis 3/914 138/7206 2.30673517298e-05 ko03013 RNA transport 5/914 166/7206 2.55666100934e-05 ko04744 Phototransduction 14/914 36/7206 6.41555872273e-05 ko05164 Influenza A 6/914 167/7206 8.15431619367e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/914 14/7206 9.63753165422e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 23/914 79/7206 9.89018944738e-05 ko04966 Collecting duct acid secretion 11/914 26/7206 0.000162069234832 ko04141 Protein processing in endoplasmic reticulum 8/914 184/7206 0.000180665707808 ko04730 Long-term depression 22/914 78/7206 0.00020925566296 ko04621 NOD-like receptor signaling pathway 6/914 157/7206 0.000226911243797 ko04540 Gap junction 31/914 128/7206 0.000384867060801 ko04924 Renin secretion 23/914 86/7206 0.00042500720086 ko05322 Systemic lupus erythematosus 6/914 151/7206 0.000449629575326 ko03008 Ribosome biogenesis in eukaryotes 1/914 79/7206 0.000489966025043 ko04932 Non-alcoholic fatty liver disease (NAFLD) 9/914 182/7206 0.000643771710642 ko04146 Peroxisome 2/914 89/7206 0.00106235913598 ko04971 Gastric acid secretion 24/914 98/7206 0.0011331294437 ko05169 Epstein-Barr virus infection 12/914 206/7206 0.00188695804695 ko00240 Pyrimidine metabolism 4/914 110/7206 0.00209978164783 ko04260 Cardiac muscle contraction 23/914 98/7206 0.00313285453425 ko01200 Carbon metabolism 6/914 128/7206 0.00439778455791 ko05140 Leishmaniasis 2/914 75/7206 0.00464991432205 ko04022 cGMP-PKG signaling pathway 42/914 216/7206 0.00475853338517 ko04612 Antigen processing and presentation 2/914 77/7206 0.00491336057027 ko00330 Arginine and proline metabolism 1/914 61/7206 0.00553860002121 ko04014 Ras signaling pathway 51/914 279/7206 0.00580581560291 ko05205 Proteoglycans in cancer 20/914 271/7206 0.00669338776466 ko04214 Apoptosis - fly 2/914 72/7206 0.00674728935172 ko04925 Aldosterone synthesis and secretion 23/914 105/7206 0.00729385284883 ko03018 RNA degradation 3/914 84/7206 0.00760166550138 ko04950 Maturity onset diabetes of the young 9/914 29/7206 0.00768575880764 ko05162 Measles 6/914 120/7206 0.00801721595383 ko04064 NF-kappa B signaling pathway 4/914 96/7206 0.00802399890266 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/914 59/7206 0.00876847791612 ko04972 Pancreatic secretion 24/914 111/7206 0.00877627574085 ko05414 Dilated cardiomyopathy 24/914 112/7206 0.00917322850724 ko05161 Hepatitis B 11/914 173/7206 0.0103902843833 ko00280 Valine, leucine and isoleucine degradation 1/914 54/7206 0.0118439446847 ko05110 Vibrio cholerae infection 15/914 63/7206 0.0125746661498 ko04640 Hematopoietic cell lineage 2/914 64/7206 0.0139317922077 ko04110 Cell cycle 9/914 145/7206 0.0159663294458 ko04630 Jak-STAT signaling pathway 8/914 132/7206 0.0172227181955 ko04626 Plant-pathogen interaction 6/914 18/7206 0.019715245288 ko00561 Glycerolipid metabolism 2/914 63/7206 0.0204237539735 ko05146 Amoebiasis 5/914 99/7206 0.0211442446908 ko00310 Lysine degradation 3/914 73/7206 0.0211566012608 ko04391 Hippo signaling pathway - fly 19/914 90/7206 0.0240292963561 ko04964 Proximal tubule bicarbonate reclamation 8/914 29/7206 0.0242176736842 ko03420 Nucleotide excision repair 1/914 46/7206 0.0250337743613 ko05219 Bladder cancer 1/914 48/7206 0.0261563433447 ko04740 Olfactory transduction 17/914 80/7206 0.0272463556598 ko05131 Shigellosis 4/914 82/7206 0.029254489452 ko05166 HTLV-I infection 25/914 292/7206 0.0308404360448 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/914 15/7206 0.0327253031076 ko05016 Huntington's disease 17/914 215/7206 0.036626043827 ko05418 Fluid shear stress and atherosclerosis 13/914 173/7206 0.037135359861 ko03022 Basal transcription factors 1/914 44/7206 0.0375066279181 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 7/914 26/7206 0.0386934089577 ko00071 Fatty acid degradation 1/914 45/7206 0.0387764488336 ko04211 Longevity regulating pathway 8/914 123/7206 0.0392695313765 ko00480 Glutathione metabolism 2/914 55/7206 0.0406859349487 ko04611 Platelet activation 12/914 163/7206 0.0420121727592 ko04140 Autophagy - animal 12/914 164/7206 0.0424462321501