ko pathway ratio_in_study ratio_in_pop p_value ko04360 Axon guidance 61/617 233/7206 4.0543551238e-16 ko05033 Nicotine addiction 27/617 56/7206 6.00699336221e-15 ko04727 GABAergic synapse 37/617 110/7206 7.43965963294e-14 ko05032 Morphine addiction 37/617 110/7206 7.43965963294e-14 ko04724 Glutamatergic synapse 39/617 152/7206 2.02573612684e-10 ko04744 Phototransduction 17/617 36/7206 1.05553505766e-09 ko04024 cAMP signaling pathway 55/617 279/7206 2.33885950993e-09 ko04723 Retrograde endocannabinoid signaling 40/617 175/7206 4.76145305918e-09 ko04721 Synaptic vesicle cycle 25/617 80/7206 5.09482802787e-09 ko04728 Dopaminergic synapse 41/617 185/7206 7.97607641333e-09 ko04725 Cholinergic synapse 37/617 160/7206 1.3104995974e-08 ko04713 Circadian entrainment 31/617 136/7206 2.8492374414e-07 ko04514 Cell adhesion molecules (CAMs) 27/617 130/7206 1.08599675201e-05 ko04726 Serotonergic synapse 27/617 137/7206 3.36711667579e-05 ko04391 Hippo signaling pathway - fly 20/617 90/7206 5.48303691592e-05 ko03040 Spliceosome 1/617 145/7206 6.10673853875e-05 ko04080 Neuroactive ligand-receptor interaction 60/617 423/7206 7.10875366603e-05 ko05203 Viral carcinogenesis 8/617 277/7206 0.000167448618627 ko05322 Systemic lupus erythematosus 2/617 151/7206 0.000307765220671 ko05030 Cocaine addiction 16/617 73/7206 0.000355091590546 ko03013 RNA transport 3/617 166/7206 0.000385937658938 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/617 14/7206 0.000634637924583 ko04010 MAPK signaling pathway 45/617 321/7206 0.000981960045072 ko04550 Signaling pathways regulating pluripotency of stem cells 27/617 165/7206 0.000988012676498 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 8/617 26/7206 0.00107258372455 ko04060 Cytokine-cytokine receptor interaction 5/617 191/7206 0.00142600397476 ko04141 Protein processing in endoplasmic reticulum 5/617 184/7206 0.00192905231254 ko01200 Carbon metabolism 2/617 128/7206 0.00197687431605 ko04911 Insulin secretion 20/617 117/7206 0.00234187019003 ko04512 ECM-receptor interaction 15/617 79/7206 0.00333727792043 ko00240 Pyrimidine metabolism 2/617 110/7206 0.00551341236677 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/617 79/7206 0.00739802580691 ko04217 Necroptosis 6/617 178/7206 0.00930041954247 ko04120 Ubiquitin mediated proteolysis 4/617 138/7206 0.012943591418 ko04621 NOD-like receptor signaling pathway 5/617 157/7206 0.0131213794897 ko03008 Ribosome biogenesis in eukaryotes 1/617 79/7206 0.0135023564148 ko05217 Basal cell carcinoma 12/617 68/7206 0.0140336416507 ko04064 NF-kappa B signaling pathway 2/617 96/7206 0.0159807943713 ko04921 Oxytocin signaling pathway 28/617 209/7206 0.0164229805502 ko00515 Mannose type O-glycan biosynthesis 6/617 25/7206 0.0166183746421 ko00564 Glycerophospholipid metabolism 2/617 99/7206 0.0166616328871 ko04742 Taste transduction 11/617 61/7206 0.017498759876 ko05016 Huntington's disease 9/617 215/7206 0.0179809187353 ko04330 Notch signaling pathway 11/617 62/7206 0.0188078123355 ko04520 Adherens junction 16/617 103/7206 0.0190501375428 ko04261 Adrenergic signaling in cardiomyocytes 27/617 205/7206 0.022059884888 ko05169 Epstein-Barr virus infection 9/617 206/7206 0.0305540175903 ko01230 Biosynthesis of amino acids 2/617 85/7206 0.0319779880787 ko04146 Peroxisome 2/617 89/7206 0.0330430979361 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/617 15/7206 0.0338919331064 ko05031 Amphetamine addiction 14/617 91/7206 0.0346927708749 ko05414 Dilated cardiomyopathy 16/617 112/7206 0.0391355650426 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/617 182/7206 0.0430401824352 ko04392 Hippo signaling pathway -multiple species 6/617 31/7206 0.044717615683 ko04138 Autophagy - yeast 2/617 81/7206 0.0449929795928 ko05205 Proteoglycans in cancer 14/617 271/7206 0.0454147384854 ko05146 Amoebiasis 3/617 99/7206 0.0455700447201 ko05162 Measles 4/617 120/7206 0.0457212672032 ko04930 Type II diabetes mellitus 9/617 54/7206 0.0459644676046 ko04611 Platelet activation 7/617 163/7206 0.0470814911189 ko05210 Colorectal cancer 13/617 86/7206 0.0484677349