ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 102/833 423/7206 7.66324663345e-14 ko04744 Phototransduction 23/833 36/7206 1.11801595282e-13 ko05032 Morphine addiction 41/833 110/7206 1.62315298836e-12 ko04724 Glutamatergic synapse 48/833 152/7206 2.22141134139e-11 ko04070 Phosphatidylinositol signaling system 38/833 112/7206 2.74466781303e-10 ko04727 GABAergic synapse 37/833 110/7206 6.25812838935e-10 ko04024 cAMP signaling pathway 68/833 279/7206 1.2270832057e-09 ko05033 Nicotine addiction 23/833 56/7206 1.56480741377e-08 ko04725 Cholinergic synapse 44/833 160/7206 2.13643821241e-08 ko04072 Phospholipase D signaling pathway 50/833 197/7206 4.46908367432e-08 ko04020 Calcium signaling pathway 61/833 265/7206 7.15546320398e-08 ko04713 Circadian entrainment 38/833 136/7206 1.60790439085e-07 ko04911 Insulin secretion 34/833 117/7206 1.90168769297e-07 ko05322 Systemic lupus erythematosus 1/833 151/7206 2.37727144585e-07 ko03040 Spliceosome 1/833 145/7206 5.43846995533e-07 ko04723 Retrograde endocannabinoid signaling 42/833 175/7206 3.11398086772e-06 ko03013 RNA transport 3/833 166/7206 3.60133266512e-06 ko03010 Ribosome 1/833 129/7206 4.3558961906e-06 ko04726 Serotonergic synapse 35/833 137/7206 4.35781289693e-06 ko04721 Synaptic vesicle cycle 24/833 80/7206 6.56330469232e-06 ko04710 Circadian rhythm 16/833 43/7206 1.13452531315e-05 ko04022 cGMP-PKG signaling pathway 47/833 216/7206 1.2233049456e-05 ko04921 Oxytocin signaling pathway 46/833 209/7206 1.31678419091e-05 ko05231 Choline metabolism in cancer 32/833 134/7206 5.10645464916e-05 ko04970 Salivary secretion 25/833 95/7206 5.91159457547e-05 ko04728 Dopaminergic synapse 40/833 185/7206 9.30550032368e-05 ko04261 Adrenergic signaling in cardiomyocytes 42/833 205/7206 0.000209922928522 ko04960 Aldosterone-regulated sodium reabsorption 13/833 41/7206 0.000477003440027 ko00562 Inositol phosphate metabolism 22/833 89/7206 0.000589219330836 ko04014 Ras signaling pathway 51/833 279/7206 0.00076327873409 ko04972 Pancreatic secretion 25/833 111/7206 0.000838478877302 ko04110 Cell cycle 5/833 145/7206 0.000877027203441 ko04010 MAPK signaling pathway 57/833 321/7206 0.000878577852477 ko05030 Cocaine addiction 18/833 73/7206 0.00141038806757 ko05031 Amphetamine addiction 21/833 91/7206 0.00149553382164 ko04742 Taste transduction 16/833 61/7206 0.00170605378609 ko04925 Aldosterone synthesis and secretion 23/833 105/7206 0.00194097676969 ko04711 Circadian rhythm - fly 6/833 13/7206 0.00196080008156 ko04971 Gastric acid secretion 22/833 98/7206 0.00204018548194 ko04514 Cell adhesion molecules (CAMs) 27/833 130/7206 0.00208094674621 ko04720 Long-term potentiation 22/833 99/7206 0.00221267754204 ko04730 Long-term depression 18/833 78/7206 0.00359552705152 ko04750 Inflammatory mediator regulation of TRP channels 25/833 122/7206 0.00385251005267 ko04666 Fc gamma R-mediated phagocytosis 25/833 122/7206 0.00385251005267 ko04964 Proximal tubule bicarbonate reclamation 9/833 29/7206 0.00414037573126 ko04120 Ubiquitin mediated proteolysis 6/833 138/7206 0.00449147778667 ko04973 Carbohydrate digestion and absorption 11/833 42/7206 0.00674195804026 ko04923 Regulation of lipolysis in adipocytes 17/833 77/7206 0.00678526228787 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/833 59/7206 0.00690940156426 ko04930 Type II diabetes mellitus 13/833 54/7206 0.00853066740294 ko05203 Viral carcinogenesis 19/833 277/7206 0.0122959006279 ko05230 Central carbon metabolism in cancer 17/833 81/7206 0.013115207366 ko04141 Protein processing in endoplasmic reticulum 11/833 184/7206 0.0137959466087 ko04270 Vascular smooth muscle contraction 28/833 154/7206 0.0146865236844 ko05016 Huntington's disease 14/833 215/7206 0.0168000260463 ko04919 Thyroid hormone signaling pathway 26/833 143/7206 0.0169182753753 ko05217 Basal cell carcinoma 2/833 68/7206 0.0207818613704 ko03015 mRNA surveillance pathway 4/833 93/7206 0.0220209655165 ko00230 Purine metabolism 33/833 194/7206 0.0221003658191 ko04213 Longevity regulating pathway - multiple species 17/833 86/7206 0.0255289490941 ko04918 Thyroid hormone synthesis 17/833 86/7206 0.0255289490941 ko04360 Axon guidance 38/833 233/7206 0.0280309091359 ko05130 Pathogenic Escherichia coli infection 3/833 77/7206 0.0305757921748 ko04612 Antigen processing and presentation 3/833 77/7206 0.0305757921748 ko04976 Bile secretion 16/833 80/7206 0.0322424218275 ko05168 Herpes simplex infection 12/833 182/7206 0.033854332473 ko04922 Glucagon signaling pathway 23/833 128/7206 0.0348004446543 ko02010 ABC transporters 9/833 39/7206 0.038836840606 ko04931 Insulin resistance 24/833 137/7206 0.0414078980457 ko05133 Pertussis 4/833 87/7206 0.0414136215249 ko05012 Parkinson's disease 10/833 155/7206 0.0420890317478 ko04622 RIG-I-like receptor signaling pathway 2/833 62/7206 0.0429029134652