ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 53/369 145/7206 2.35500163568e-32 ko04111 Cell cycle - yeast 38/369 90/7206 4.40962583995e-26 ko03030 DNA replication 23/369 38/7206 8.08032948143e-21 ko03460 Fanconi anemia pathway 24/369 51/7206 3.27801428543e-18 ko04113 Meiosis - yeast 27/369 70/7206 1.35063084906e-17 ko03440 Homologous recombination 21/369 41/7206 4.73657606567e-17 ko03410 Base excision repair 17/369 38/7206 8.54561792359e-13 ko03040 Spliceosome 32/369 145/7206 9.22823842219e-13 ko03430 Mismatch repair 12/369 22/7206 1.10827073901e-10 ko03420 Nucleotide excision repair 13/369 46/7206 2.93757617466e-07 ko00240 Pyrimidine metabolism 19/369 110/7206 2.4916708852e-06 ko04144 Endocytosis 2/369 342/7206 3.67631982757e-06 ko05322 Systemic lupus erythematosus 22/369 151/7206 7.52276384498e-06 ko03008 Ribosome biogenesis in eukaryotes 15/369 79/7206 8.77077343671e-06 ko04024 cAMP signaling pathway 1/369 279/7206 1.01640716424e-05 ko03013 RNA transport 23/369 166/7206 1.09739146123e-05 ko04020 Calcium signaling pathway 1/369 265/7206 2.27915516816e-05 ko04114 Oocyte meiosis 20/369 139/7206 2.36445044915e-05 ko05206 MicroRNAs in cancer 23/369 177/7206 3.16279310682e-05 ko05166 HTLV-I infection 30/369 292/7206 0.000212530765405 ko03018 RNA degradation 13/369 84/7206 0.0003069853318 ko04921 Oxytocin signaling pathway 1/369 209/7206 0.000339107180091 ko04062 Chemokine signaling pathway 1/369 201/7206 0.000497002855293 ko04261 Adrenergic signaling in cardiomyocytes 1/369 205/7206 0.000525418741877 ko05203 Viral carcinogenesis 28/369 277/7206 0.000671331586239 ko04060 Cytokine-cytokine receptor interaction 1/369 191/7206 0.000723740524216 ko04914 Progesterone-mediated oocyte maturation 14/369 104/7206 0.000786211507529 ko04728 Dopaminergic synapse 1/369 185/7206 0.00106432193523 ko05152 Tuberculosis 1/369 187/7206 0.0010826993597 ko04330 Notch signaling pathway 10/369 62/7206 0.00108320818806 ko04115 p53 signaling pathway 11/369 74/7206 0.00124447567715 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/369 182/7206 0.00165470176501 ko04015 Rap1 signaling pathway 4/369 278/7206 0.00200847939459 ko04910 Insulin signaling pathway 1/369 172/7206 0.00232670174415 ko04120 Ubiquitin mediated proteolysis 16/369 138/7206 0.00241312114956 ko03015 mRNA surveillance pathway 12/369 93/7206 0.00264339123188 ko04151 PI3K-Akt signaling pathway 8/369 390/7206 0.00287901680662 ko04071 Sphingolipid signaling pathway 1/369 162/7206 0.00332119105175 ko04140 Autophagy - animal 1/369 164/7206 0.00338227019937 ko00310 Lysine degradation 10/369 73/7206 0.00379756282639 ko04072 Phospholipase D signaling pathway 2/369 197/7206 0.00450292429214 ko05160 Hepatitis C 1/369 153/7206 0.00481176677812 ko05222 Small cell lung cancer 11/369 89/7206 0.00548052754508 ko04141 Protein processing in endoplasmic reticulum 2/369 184/7206 0.00614890678637 ko05034 Alcoholism 22/369 238/7206 0.00648419973334 ko04670 Leukocyte transendothelial migration 1/369 151/7206 0.00744143179294 ko04014 Ras signaling pathway 5/369 279/7206 0.00770715221047 ko04371 Apelin signaling pathway 2/369 177/7206 0.00875645523169 ko04931 Insulin resistance 1/369 137/7206 0.0101433832993 ko04810 Regulation of actin cytoskeleton 5/369 264/7206 0.0101602533501 ko04510 Focal adhesion 4/369 240/7206 0.0103431479054 ko05202 Transcriptional misregulation in cancer 18/369 188/7206 0.0104507064422 ko05205 Proteoglycans in cancer 5/369 271/7206 0.010487248808 ko04218 Cellular senescence 17/369 177/7206 0.0137178820065 ko04540 Gap junction 1/369 128/7206 0.014699103432 ko05142 Chagas disease (American trypanosomiasis) 1/369 130/7206 0.0147210724872 ko05168 Herpes simplex infection 17/369 182/7206 0.015503851193 ko04722 Neurotrophin signaling pathway 2/369 160/7206 0.0174544288859 ko04912 GnRH signaling pathway 1/369 122/7206 0.0212706657917 ko04750 Inflammatory mediator regulation of TRP channels 1/369 122/7206 0.0212706657917 ko04211 Longevity regulating pathway 1/369 123/7206 0.0213652023863 ko05145 Toxoplasmosis 1/369 126/7206 0.021991609465 ko03022 Basal transcription factors 6/369 44/7206 0.0235318214244 ko04010 MAPK signaling pathway 8/369 321/7206 0.0268022436706 ko04360 Axon guidance 5/369 233/7206 0.0333865075928 ko05418 Fluid shear stress and atherosclerosis 3/369 173/7206 0.0354496220287 ko04310 Wnt signaling pathway 16/369 181/7206 0.0374959554616 ko04925 Aldosterone synthesis and secretion 1/369 105/7206 0.0440808752392 ko04530 Tight junction 5/369 228/7206 0.045091731588 ko04933 AGE-RAGE signaling pathway in diabetic complications 2/369 135/7206 0.0481477626797 ko05231 Choline metabolism in cancer 2/369 134/7206 0.0481785932061