ko pathway ratio_in_study ratio_in_pop p_value ko04260 Cardiac muscle contraction 12/110 98/7206 2.36759705335e-08 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/110 79/7206 2.40062868929e-08 ko05410 Hypertrophic cardiomyopathy (HCM) 12/110 100/7206 2.98472985638e-08 ko01200 Carbon metabolism 13/110 128/7206 5.84348779075e-08 ko04921 Oxytocin signaling pathway 16/110 209/7206 8.8804087378e-08 ko04261 Adrenergic signaling in cardiomyocytes 15/110 205/7206 4.20525456025e-07 ko05414 Dilated cardiomyopathy 10/110 112/7206 7.01308105602e-06 ko00010 Glycolysis / Gluconeogenesis 8/110 74/7206 1.49093839978e-05 ko00710 Carbon fixation in photosynthetic organisms 5/110 27/7206 4.67290038063e-05 ko04922 Glucagon signaling pathway 9/110 128/7206 0.000135962557911 ko00680 Methane metabolism 5/110 34/7206 0.000147931090799 ko04152 AMPK signaling pathway 10/110 161/7206 0.000161101114491 ko00500 Starch and sucrose metabolism 5/110 35/7206 0.000170504231827 ko05416 Viral myocarditis 6/110 55/7206 0.000174164724779 ko01230 Biosynthesis of amino acids 7/110 85/7206 0.000295590695679 ko04022 cGMP-PKG signaling pathway 11/110 216/7206 0.000428620361699 ko04020 Calcium signaling pathway 12/110 265/7206 0.000675723282195 ko00030 Pentose phosphate pathway 4/110 32/7206 0.00132975664834 ko00020 Citrate cycle (TCA cycle) 4/110 35/7206 0.00186939756952 ko00362 Benzoate degradation 2/110 6/7206 0.00332784619407 ko04910 Insulin signaling pathway 8/110 172/7206 0.00464102219599 ko00620 Pyruvate metabolism 4/110 46/7206 0.00512432152456 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/110 182/7206 0.00649528148214 ko04911 Insulin secretion 6/110 117/7206 0.00877248205712 ko04930 Type II diabetes mellitus 4/110 54/7206 0.00904941478567 ko04010 MAPK signaling pathway 11/110 321/7206 0.00958883060081 ko04924 Renin secretion 5/110 86/7206 0.00989547772538 ko04920 Adipocytokine signaling pathway 5/110 89/7206 0.01137875953 ko00640 Propanoate metabolism 3/110 34/7206 0.0146893510337 ko04970 Salivary secretion 5/110 95/7206 0.0147867212931 ko04371 Apelin signaling pathway 7/110 177/7206 0.0183035092594 ko00630 Glyoxylate and dicarboxylate metabolism 3/110 38/7206 0.019820516287 ko00051 Fructose and mannose metabolism 3/110 42/7206 0.0258192646791 ko04973 Carbohydrate digestion and absorption 3/110 42/7206 0.0258192646791 ko04923 Regulation of lipolysis in adipocytes 4/110 77/7206 0.0297017292562 ko04270 Vascular smooth muscle contraction 6/110 154/7206 0.0300430325885 ko05010 Alzheimer's disease 7/110 202/7206 0.0344625231949 ko05230 Central carbon metabolism in cancer 4/110 81/7206 0.0348806026843 ko04725 Cholinergic synapse 6/110 160/7206 0.0352779229639 ko01210 2-Oxocarboxylic acid metabolism 2/110 20/7206 0.0366868065347 ko03018 RNA degradation 4/110 84/7206 0.039088420691 ko00380 Tryptophan metabolism 3/110 50/7206 0.0404088774103 ko04213 Longevity regulating pathway - multiple species 4/110 86/7206 0.042048409164 ko02026 Biofilm formation - Escherichia coli 1/110 3/7206 0.0451058259173 ko00280 Valine, leucine and isoleucine degradation 3/110 54/7206 0.0489710056674