ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1064	423/7206	1.46779993366e-49
ko04724	Glutamatergic synapse	83/1064	152/7206	5.17031132091e-31
ko05033	Nicotine addiction	45/1064	56/7206	5.28019184126e-28
ko05032	Morphine addiction	61/1064	110/7206	1.63673182695e-23
ko04727	GABAergic synapse	60/1064	110/7206	1.21871355334e-22
ko04713	Circadian entrainment	67/1064	136/7206	7.36472466407e-22
ko04721	Synaptic vesicle cycle	49/1064	80/7206	1.03619984915e-21
ko04728	Dopaminergic synapse	80/1064	185/7206	2.54915848418e-21
ko04725	Cholinergic synapse	73/1064	160/7206	3.30186713191e-21
ko04723	Retrograde endocannabinoid signaling	72/1064	175/7206	8.03607081466e-18
ko04024	cAMP signaling pathway	96/1064	279/7206	6.85051580695e-17
ko04742	Taste transduction	35/1064	61/7206	1.26794017273e-14
ko04726	Serotonergic synapse	56/1064	137/7206	5.671488998e-14
ko04020	Calcium signaling pathway	86/1064	265/7206	1.46712088684e-13
ko04744	Phototransduction	25/1064	36/7206	1.54673240487e-13
ko04921	Oxytocin signaling pathway	73/1064	209/7206	2.07142966699e-13
ko04911	Insulin secretion	48/1064	117/7206	3.16546640077e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1064	205/7206	7.61960341354e-11
ko04720	Long-term potentiation	40/1064	99/7206	3.64073275822e-10
ko05031	Amphetamine addiction	37/1064	91/7206	1.35780640029e-09
ko03040	Spliceosome	1/1064	145/7206	3.56914665598e-09
ko05203	Viral carcinogenesis	12/1064	277/7206	2.03318020149e-08
ko04970	Salivary secretion	36/1064	95/7206	2.10630547867e-08
ko04360	Axon guidance	65/1064	233/7206	1.47140174867e-07
ko04966	Collecting duct acid secretion	15/1064	26/7206	4.8908919247e-07
ko04070	Phosphatidylinositol signaling system	37/1064	112/7206	1.09218596725e-06
ko05322	Systemic lupus erythematosus	4/1064	151/7206	1.14894501732e-06
ko04971	Gastric acid secretion	33/1064	98/7206	2.06037999642e-06
ko05168	Herpes simplex infection	7/1064	182/7206	2.24141890433e-06
ko04621	NOD-like receptor signaling pathway	5/1064	157/7206	3.33507769146e-06
ko04060	Cytokine-cytokine receptor interaction	8/1064	191/7206	3.73337888141e-06
ko04925	Aldosterone synthesis and secretion	34/1064	105/7206	4.54675486774e-06
ko04022	cGMP-PKG signaling pathway	57/1064	216/7206	5.80369936187e-06
ko04740	Olfactory transduction	28/1064	80/7206	7.50743136662e-06
ko04010	MAPK signaling pathway	77/1064	321/7206	7.99007022261e-06
ko05164	Influenza A	7/1064	167/7206	1.32974544078e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1064	79/7206	1.50324071485e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1064	74/7206	1.66909369328e-05
ko03013	RNA transport	7/1064	166/7206	1.91214567187e-05
ko04120	Ubiquitin mediated proteolysis	5/1064	138/7206	2.90929056979e-05
ko04014	Ras signaling pathway	67/1064	279/7206	3.0955079468e-05
ko04141	Protein processing in endoplasmic reticulum	9/1064	184/7206	3.13338998386e-05
ko05030	Cocaine addiction	25/1064	73/7206	3.21413318115e-05
ko04730	Long-term depression	26/1064	78/7206	3.2155097915e-05
ko04745	Phototransduction - fly	16/1064	38/7206	4.08407758543e-05
ko04610	Complement and coagulation cascades	1/1064	79/7206	8.22171316456e-05
ko04924	Renin secretion	27/1064	86/7206	8.25143351924e-05
ko04972	Pancreatic secretion	32/1064	111/7206	0.000118809444799
ko04612	Antigen processing and presentation	1/1064	77/7206	0.000127880554067
ko04260	Cardiac muscle contraction	29/1064	98/7206	0.000142961911457
ko04072	Phospholipase D signaling pathway	49/1064	197/7206	0.000144891157832
ko05169	Epstein-Barr virus infection	13/1064	206/7206	0.000202440474251
ko04110	Cell cycle	7/1064	145/7206	0.000207489091276
ko04514	Cell adhesion molecules (CAMs)	35/1064	130/7206	0.000252432145202
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1064	14/7206	0.000288027758053
ko05414	Dilated cardiomyopathy	31/1064	112/7206	0.00038019512342
ko04064	NF-kappa B signaling pathway	3/1064	96/7206	0.000387260543208
ko05110	Vibrio cholerae infection	20/1064	63/7206	0.000527253314402
ko03008	Ribosome biogenesis in eukaryotes	2/1064	79/7206	0.000627839083244
ko05140	Leishmaniasis	2/1064	75/7206	0.00091457991169
ko04540	Gap junction	33/1064	128/7206	0.000952303313838
ko00562	Inositol phosphate metabolism	25/1064	89/7206	0.00127241412741
ko04915	Estrogen signaling pathway	33/1064	131/7206	0.00166018245439
ko05205	Proteoglycans in cancer	23/1064	271/7206	0.00215423047196
ko04626	Plant-pathogen interaction	8/1064	18/7206	0.00242062876895
ko00480	Glutathione metabolism	1/1064	55/7206	0.00332019873847
ko04146	Peroxisome	4/1064	89/7206	0.00376590476073
ko00240	Pyrimidine metabolism	6/1064	110/7206	0.00398713461891
ko04750	Inflammatory mediator regulation of TRP channels	30/1064	122/7206	0.00419084025582
ko05161	Hepatitis B	13/1064	173/7206	0.00462254086529
ko00590	Arachidonic acid metabolism	1/1064	52/7206	0.00490957527082
ko05166	HTLV-I infection	27/1064	292/7206	0.00534213584867
ko00330	Arginine and proline metabolism	2/1064	61/7206	0.00611777548543
ko04330	Notch signaling pathway	2/1064	62/7206	0.00616226093512
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1064	100/7206	0.00645737075753
ko04976	Bile secretion	21/1064	80/7206	0.00646222576638
ko04964	Proximal tubule bicarbonate reclamation	10/1064	29/7206	0.00652327207146
ko04214	Apoptosis - fly	3/1064	72/7206	0.00693831726087
ko00260	Glycine, serine and threonine metabolism	1/1064	48/7206	0.00711958753945
ko04923	Regulation of lipolysis in adipocytes	20/1064	77/7206	0.00901558953323
ko05162	Measles	8/1064	120/7206	0.00903694351707
ko04371	Apelin signaling pathway	39/1064	177/7206	0.00955991061534
ko00071	Fatty acid degradation	1/1064	45/7206	0.0106018831662
ko03420	Nucleotide excision repair	1/1064	46/7206	0.0107491760852
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1064	92/7206	0.0108702621045
ko05321	Inflammatory bowel disease (IBD)	2/1064	56/7206	0.0129031750008
ko04722	Neurotrophin signaling pathway	35/1064	160/7206	0.0131032717773
ko04657	IL-17 signaling pathway	5/1064	87/7206	0.0141708718771
ko00983	Drug metabolism - other enzymes	1/1064	42/7206	0.0157764366012
ko03022	Basal transcription factors	1/1064	44/7206	0.0164619272106
ko04350	TGF-beta signaling pathway	7/1064	103/7206	0.0173101549469
ko03018	RNA degradation	5/1064	84/7206	0.0194017627975
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1064	182/7206	0.0195911778367
ko00310	Lysine degradation	4/1064	73/7206	0.0198606461111
ko04640	Hematopoietic cell lineage	3/1064	64/7206	0.019944741384
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1064	40/7206	0.0235227492132
ko00140	Steroid hormone biosynthesis	1/1064	41/7206	0.0241995045602
ko04217	Necroptosis	16/1064	178/7206	0.0247166913097
ko05214	Glioma	19/1064	79/7206	0.0250482565834
ko04973	Carbohydrate digestion and absorption	12/1064	42/7206	0.0254874068644
ko04062	Chemokine signaling pathway	41/1064	201/7206	0.0263403602466
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1064	59/7206	0.0266354024708
ko00380	Tryptophan metabolism	2/1064	50/7206	0.0267691462056
ko05131	Shigellosis	5/1064	82/7206	0.0268505016167
ko04912	GnRH signaling pathway	27/1064	122/7206	0.0277570940652
ko04622	RIG-I-like receptor signaling pathway	3/1064	62/7206	0.0286880826268
ko05145	Toxoplasmosis	10/1064	126/7206	0.0303199459183
ko04071	Sphingolipid signaling pathway	34/1064	162/7206	0.0324382984741
ko05133	Pertussis	6/1064	87/7206	0.0333935278519
ko00982	Drug metabolism - cytochrome P450	1/1064	37/7206	0.0347555470092
ko05231	Choline metabolism in cancer	29/1064	134/7206	0.0355040760682
ko00630	Glyoxylate and dicarboxylate metabolism	1/1064	38/7206	0.0355599167091
ko05016	Huntington's disease	21/1064	215/7206	0.0397340055811
ko04658	Th1 and Th2 cell differentiation	7/1064	96/7206	0.0411693057707
ko04210	Apoptosis	17/1064	180/7206	0.0427441612861
ko01200	Carbon metabolism	11/1064	128/7206	0.0445565053464
ko05213	Endometrial cancer	15/1064	62/7206	0.0461053501284
ko04015	Rap1 signaling pathway	53/1064	278/7206	0.046860204424
ko04115	p53 signaling pathway	5/1064	74/7206	0.0484301170254
ko01524	Platinum drug resistance	5/1064	76/7206	0.0491285596446