ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	33/851	56/7206	2.96045843664e-17
ko04744	Phototransduction	26/851	36/7206	4.22847462967e-17
ko04080	Neuroactive ligand-receptor interaction	110/851	423/7206	8.43504044726e-17
ko04727	GABAergic synapse	46/851	110/7206	9.04061923875e-16
ko04724	Glutamatergic synapse	54/851	152/7206	1.16600003881e-14
ko05032	Morphine addiction	44/851	110/7206	2.69850042989e-14
ko04713	Circadian entrainment	46/851	136/7206	8.44642579177e-12
ko04721	Synaptic vesicle cycle	32/851	80/7206	9.54361796108e-11
ko04723	Retrograde endocannabinoid signaling	50/851	175/7206	1.2077635779e-09
ko04728	Dopaminergic synapse	50/851	185/7206	9.4488098845e-09
ko04725	Cholinergic synapse	45/851	160/7206	1.34055484279e-08
ko04972	Pancreatic secretion	35/851	111/7206	2.18844555004e-08
ko04976	Bile secretion	28/851	80/7206	4.65044120192e-08
ko04020	Calcium signaling pathway	62/851	265/7206	9.03255787348e-08
ko04024	cAMP signaling pathway	63/851	279/7206	2.08940002407e-07
ko04970	Salivary secretion	30/851	95/7206	2.15136925378e-07
ko04726	Serotonergic synapse	38/851	137/7206	2.74075055564e-07
ko05203	Viral carcinogenesis	9/851	277/7206	5.11911454087e-07
ko04742	Taste transduction	22/851	61/7206	7.14162299119e-07
ko04740	Olfactory transduction	26/851	80/7206	7.43451570766e-07
ko04911	Insulin secretion	33/851	117/7206	1.36905643594e-06
ko05164	Influenza A	3/851	167/7206	2.4056109231e-06
ko05169	Epstein-Barr virus infection	6/851	206/7206	5.28681347814e-06
ko04120	Ubiquitin mediated proteolysis	2/851	138/7206	7.36113196647e-06
ko05162	Measles	1/851	120/7206	9.78826119375e-06
ko03013	RNA transport	4/851	166/7206	1.48131382475e-05
ko05166	HTLV-I infection	13/851	292/7206	1.64913454937e-05
ko05030	Cocaine addiction	22/851	73/7206	2.05492947259e-05
ko04978	Mineral absorption	15/851	40/7206	2.47719068063e-05
ko05161	Hepatitis B	5/851	173/7206	3.77955955589e-05
ko04971	Gastric acid secretion	26/851	98/7206	4.94447218005e-05
ko04964	Proximal tubule bicarbonate reclamation	12/851	29/7206	5.19746642497e-05
ko02010	ABC transporters	14/851	39/7206	8.08698092691e-05
ko04974	Protein digestion and absorption	25/851	96/7206	9.33214727433e-05
ko04514	Cell adhesion molecules (CAMs)	31/851	130/7206	9.42515944079e-05
ko05322	Systemic lupus erythematosus	4/851	151/7206	9.64637246104e-05
ko05031	Amphetamine addiction	24/851	91/7206	0.000107670589545
ko04921	Oxytocin signaling pathway	44/851	209/7206	0.000113981095244
ko04110	Cell cycle	4/851	145/7206	0.00013125442936
ko05200	Pathways in cancer	33/851	492/7206	0.000155036235705
ko00830	Retinol metabolism	14/851	42/7206	0.000201712977335
ko04924	Renin secretion	22/851	86/7206	0.000321773882597
ko04510	Focal adhesion	12/851	240/7206	0.000342301621656
ko04060	Cytokine-cytokine receptor interaction	8/851	191/7206	0.000366026899857
ko05205	Proteoglycans in cancer	15/851	271/7206	0.000514908609264
ko04350	TGF-beta signaling pathway	2/851	103/7206	0.000536150621314
ko04261	Adrenergic signaling in cardiomyocytes	41/851	205/7206	0.00059069714114
ko04621	NOD-like receptor signaling pathway	6/851	157/7206	0.000648145615933
ko05168	Herpes simplex infection	8/851	182/7206	0.000680255711372
ko04141	Protein processing in endoplasmic reticulum	8/851	184/7206	0.000689696545465
ko04022	cGMP-PKG signaling pathway	42/851	216/7206	0.000859429859802
ko05215	Prostate cancer	3/851	111/7206	0.000944262023217
ko04710	Circadian rhythm	13/851	43/7206	0.000974478315706
ko05016	Huntington's disease	11/851	215/7206	0.00116373669857
ko03008	Ribosome biogenesis in eukaryotes	1/851	79/7206	0.00118851338008
ko05202	Transcriptional misregulation in cancer	9/851	188/7206	0.00123998924544
ko04550	Signaling pathways regulating pluripotency of stem cells	7/851	165/7206	0.00131440228184
ko04668	TNF signaling pathway	4/851	120/7206	0.00153606248372
ko05224	Breast cancer	8/851	174/7206	0.00176922623873
ko04966	Collecting duct acid secretion	9/851	26/7206	0.00206724204596
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/851	182/7206	0.00227160507004
ko04657	IL-17 signaling pathway	2/851	87/7206	0.00230299473571
ko04720	Long-term potentiation	22/851	99/7206	0.0026600980368
ko04620	Toll-like receptor signaling pathway	3/851	100/7206	0.00274961003599
ko04217	Necroptosis	9/851	178/7206	0.00303393689
ko05145	Toxoplasmosis	5/851	126/7206	0.00319501139414
ko00350	Tyrosine metabolism	10/851	33/7206	0.00362608105725
ko04658	Th1 and Th2 cell differentiation	3/851	96/7206	0.00391357201787
ko04730	Long-term depression	18/851	78/7206	0.00421315079966
ko04810	Regulation of actin cytoskeleton	17/851	264/7206	0.00461749102028
ko00643	Styrene degradation	3/851	4/7206	0.00598780738819
ko00290	Valine, leucine and isoleucine biosynthesis	3/851	4/7206	0.00598780738819
ko04630	Jak-STAT signaling pathway	6/851	132/7206	0.00607521186845
ko04210	Apoptosis	10/851	180/7206	0.00672092863381
ko04612	Antigen processing and presentation	2/851	77/7206	0.0069755754559
ko04664	Fc epsilon RI signaling pathway	2/851	77/7206	0.0069755754559
ko04330	Notch signaling pathway	1/851	62/7206	0.00848358078765
ko04218	Cellular senescence	10/851	177/7206	0.00892174146776
ko04745	Phototransduction - fly	10/851	38/7206	0.0107351079458
ko04660	T cell receptor signaling pathway	6/851	124/7206	0.0111665485348
ko05132	Salmonella infection	4/851	98/7206	0.0114910762522
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/851	59/7206	0.0127393331502
ko00380	Tryptophan metabolism	12/851	50/7206	0.0135440626064
ko04310	Wnt signaling pathway	11/851	181/7206	0.0137542054542
ko04925	Aldosterone synthesis and secretion	21/851	105/7206	0.0138757749277
ko04614	Renin-angiotensin system	6/851	18/7206	0.0141383883564
ko04380	Osteoclast differentiation	7/851	134/7206	0.014345674113
ko04933	AGE-RAGE signaling pathway in diabetic complications	7/851	135/7206	0.0145014103553
ko05131	Shigellosis	3/851	82/7206	0.0155308034505
ko05212	Pancreatic cancer	3/851	83/7206	0.0155918148582
ko05211	Renal cell carcinoma	4/851	96/7206	0.0159502215503
ko04064	NF-kappa B signaling pathway	4/851	96/7206	0.0159502215503
ko05220	Chronic myeloid leukemia	3/851	85/7206	0.0162211214262
ko05014	Amyotrophic lateral sclerosis (ALS)	16/851	74/7206	0.0165049478964
ko04260	Cardiac muscle contraction	20/851	98/7206	0.0165701319836
ko05110	Vibrio cholerae infection	14/851	63/7206	0.0168580208782
ko00230	Purine metabolism	34/851	194/7206	0.0172879629441
ko04011	MAPK signaling pathway - yeast	1/851	53/7206	0.0175170383272
ko04975	Fat digestion and absorption	9/851	35/7206	0.0176690869737
ko05416	Viral myocarditis	1/851	55/7206	0.0183035128545
ko05217	Basal cell carcinoma	2/851	68/7206	0.0212040617738
ko04914	Progesterone-mediated oocyte maturation	5/851	104/7206	0.0212614802556
ko00340	Histidine metabolism	7/851	25/7206	0.0221996943524
ko00983	Drug metabolism - other enzymes	10/851	42/7206	0.0266878504242
ko04973	Carbohydrate digestion and absorption	10/851	42/7206	0.0266878504242
ko04070	Phosphatidylinositol signaling system	21/851	112/7206	0.026749980413
ko04622	RIG-I-like receptor signaling pathway	2/851	62/7206	0.0292571940375
ko05221	Acute myeloid leukemia	2/851	63/7206	0.0293879391214
ko05222	Small cell lung cancer	4/851	89/7206	0.0302017889496
ko05140	Leishmaniasis	3/851	75/7206	0.0303331864632
ko05206	MicroRNAs in cancer	12/851	177/7206	0.0335486132257
ko04540	Gap junction	23/851	128/7206	0.037167911284
ko04140	Autophagy - animal	11/851	164/7206	0.0375058213344
ko03420	Nucleotide excision repair	1/851	46/7206	0.0377176233879
ko04215	Apoptosis - multiple species	1/851	47/7206	0.0382048355451
ko04390	Hippo signaling pathway	13/851	188/7206	0.0383080028961
ko05219	Bladder cancer	1/851	48/7206	0.0392429960162
ko03018	RNA degradation	4/851	84/7206	0.0409267756589
ko05218	Melanoma	4/851	85/7206	0.0410964511267
ko05210	Colorectal cancer	4/851	86/7206	0.0415873773736
ko00360	Phenylalanine metabolism	5/851	17/7206	0.0418069079105
ko04214	Apoptosis - fly	3/851	72/7206	0.0422320031894
ko05418	Fluid shear stress and atherosclerosis	12/851	173/7206	0.0425502855298
ko01521	EGFR tyrosine kinase inhibitor resistance	6/851	106/7206	0.0480120646352
ko04150	mTOR signaling pathway	13/851	184/7206	0.0481261279329