ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1034	423/7206	5.81422996786e-48
ko05033	Nicotine addiction	49/1034	56/7206	1.50819829885e-34
ko04724	Glutamatergic synapse	85/1034	152/7206	9.62487195193e-34
ko05032	Morphine addiction	65/1034	110/7206	6.66278969297e-28
ko04727	GABAergic synapse	64/1034	110/7206	5.97488908232e-27
ko04713	Circadian entrainment	70/1034	136/7206	5.28681354415e-25
ko04728	Dopaminergic synapse	79/1034	185/7206	1.89089547754e-21
ko04725	Cholinergic synapse	71/1034	160/7206	1.56656218043e-20
ko04721	Synaptic vesicle cycle	46/1034	80/7206	2.16088029732e-19
ko04723	Retrograde endocannabinoid signaling	73/1034	175/7206	3.47403906813e-19
ko04024	cAMP signaling pathway	96/1034	279/7206	9.69939818624e-18
ko04744	Phototransduction	26/1034	36/7206	5.42099763342e-15
ko04911	Insulin secretion	51/1034	117/7206	1.10727431667e-14
ko04742	Taste transduction	34/1034	61/7206	4.16431142981e-14
ko04020	Calcium signaling pathway	84/1034	265/7206	1.88459735528e-13
ko04261	Adrenergic signaling in cardiomyocytes	69/1034	205/7206	1.5724473849e-12
ko04921	Oxytocin signaling pathway	69/1034	209/7206	3.61260462982e-12
ko04726	Serotonergic synapse	52/1034	137/7206	4.52345811622e-12
ko05031	Amphetamine addiction	38/1034	91/7206	1.36291345792e-10
ko04720	Long-term potentiation	39/1034	99/7206	6.21900133334e-10
ko03040	Spliceosome	1/1034	145/7206	5.65505368579e-09
ko05030	Cocaine addiction	30/1034	73/7206	1.8989131864e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1034	74/7206	2.76251211573e-08
ko04970	Salivary secretion	35/1034	95/7206	3.63634048636e-08
ko05203	Viral carcinogenesis	12/1034	277/7206	6.17144341461e-08
ko04740	Olfactory transduction	30/1034	80/7206	2.18931098999e-07
ko04060	Cytokine-cytokine receptor interaction	6/1034	191/7206	3.12015098523e-07
ko04925	Aldosterone synthesis and secretion	35/1034	105/7206	6.94863963208e-07
ko04010	MAPK signaling pathway	79/1034	321/7206	7.61824624331e-07
ko04360	Axon guidance	61/1034	233/7206	1.43094219312e-06
ko04971	Gastric acid secretion	32/1034	98/7206	3.32823504979e-06
ko05168	Herpes simplex infection	7/1034	182/7206	4.82024044168e-06
ko05322	Systemic lupus erythematosus	5/1034	151/7206	1.01222971296e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1034	79/7206	1.14734751855e-05
ko03013	RNA transport	7/1034	166/7206	2.77390429334e-05
ko05164	Influenza A	7/1034	167/7206	2.77510298448e-05
ko04260	Cardiac muscle contraction	30/1034	98/7206	3.02089073633e-05
ko04072	Phospholipase D signaling pathway	50/1034	197/7206	3.11948591392e-05
ko04514	Cell adhesion molecules (CAMs)	36/1034	130/7206	6.57137310551e-05
ko04022	cGMP-PKG signaling pathway	53/1034	216/7206	6.64020053333e-05
ko04972	Pancreatic secretion	32/1034	111/7206	9.20561681687e-05
ko04350	TGF-beta signaling pathway	3/1034	103/7206	0.000182666085629
ko05205	Proteoglycans in cancer	19/1034	271/7206	0.000190940803898
ko05414	Dilated cardiomyopathy	31/1034	112/7206	0.000194321315007
ko04745	Phototransduction - fly	14/1034	38/7206	0.000478591790857
ko04730	Long-term depression	23/1034	78/7206	0.000485691427841
ko04966	Collecting duct acid secretion	11/1034	26/7206	0.000490270390048
ko04141	Protein processing in endoplasmic reticulum	11/1034	184/7206	0.000571145990914
ko04915	Estrogen signaling pathway	33/1034	131/7206	0.000927612224549
ko04612	Antigen processing and presentation	2/1034	77/7206	0.000939884810526
ko03008	Ribosome biogenesis in eukaryotes	2/1034	79/7206	0.000967024370784
ko04976	Bile secretion	23/1034	80/7206	0.00101809553896
ko04070	Phosphatidylinositol signaling system	29/1034	112/7206	0.00102579361274
ko04110	Cell cycle	8/1034	145/7206	0.00110468772021
ko04621	NOD-like receptor signaling pathway	9/1034	157/7206	0.00111716114874
ko05169	Epstein-Barr virus infection	14/1034	206/7206	0.0011381789403
ko05161	Hepatitis B	11/1034	173/7206	0.00134517339717
ko05140	Leishmaniasis	2/1034	75/7206	0.00137844414554
ko05162	Measles	6/1034	120/7206	0.00150057718099
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1034	182/7206	0.00172861871456
ko04120	Ubiquitin mediated proteolysis	8/1034	138/7206	0.00204914005449
ko04540	Gap junction	31/1034	128/7206	0.00306472589324
ko05110	Vibrio cholerae infection	18/1034	63/7206	0.00314519249992
ko00480	Glutathione metabolism	1/1034	55/7206	0.00325956147471
ko04630	Jak-STAT signaling pathway	8/1034	132/7206	0.00376964383157
ko04146	Peroxisome	4/1034	89/7206	0.00546374318726
ko00240	Pyrimidine metabolism	6/1034	110/7206	0.00555972985709
ko04640	Hematopoietic cell lineage	2/1034	64/7206	0.00630830646444
ko03018	RNA degradation	4/1034	84/7206	0.0074604745507
ko04064	NF-kappa B signaling pathway	5/1034	96/7206	0.00764809830706
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1034	59/7206	0.00851638782298
ko04750	Inflammatory mediator regulation of TRP channels	28/1034	122/7206	0.00898754013368
ko00330	Arginine and proline metabolism	2/1034	61/7206	0.00913055279774
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1034	14/7206	0.00921582833825
ko03420	Nucleotide excision repair	1/1034	46/7206	0.0107921933809
ko00260	Glycine, serine and threonine metabolism	1/1034	48/7206	0.011196752044
ko04014	Ras signaling pathway	55/1034	279/7206	0.0114270485787
ko04924	Renin secretion	21/1034	86/7206	0.0122849285329
ko03022	Basal transcription factors	1/1034	44/7206	0.0160813687316
ko05144	Malaria	1/1034	45/7206	0.0165254240741
ko00071	Fatty acid degradation	1/1034	45/7206	0.0165254240741
ko05166	HTLV-I infection	28/1034	292/7206	0.0167986418717
ko04140	Autophagy - animal	13/1034	164/7206	0.0173350480928
ko04658	Th1 and Th2 cell differentiation	6/1034	96/7206	0.0186788711396
ko05321	Inflammatory bowel disease (IBD)	2/1034	56/7206	0.0194853526754
ko04657	IL-17 signaling pathway	5/1034	87/7206	0.0198229186855
ko05133	Pertussis	5/1034	87/7206	0.0198229186855
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1034	100/7206	0.020307189386
ko00140	Steroid hormone biosynthesis	1/1034	41/7206	0.0237976939031
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1034	40/7206	0.0238018572383
ko04670	Leukocyte transendothelial migration	12/1034	151/7206	0.0249335283613
ko04214	Apoptosis - fly	4/1034	72/7206	0.0278299011628
ko00310	Lysine degradation	4/1034	73/7206	0.0279426825968
ko04964	Proximal tubule bicarbonate reclamation	9/1034	29/7206	0.0279514012509
ko04330	Notch signaling pathway	3/1034	62/7206	0.0281637639042
ko04622	RIG-I-like receptor signaling pathway	3/1034	62/7206	0.0281637639042
ko04115	p53 signaling pathway	4/1034	74/7206	0.0284183009951
ko05215	Prostate cancer	8/1034	111/7206	0.0284886094518
ko04930	Type II diabetes mellitus	14/1034	54/7206	0.0290731755271
ko04510	Focal adhesion	23/1034	240/7206	0.0310724740318
ko04550	Signaling pathways regulating pluripotency of stem cells	14/1034	165/7206	0.0319719180641
ko04923	Regulation of lipolysis in adipocytes	18/1034	77/7206	0.03204543548
ko05231	Choline metabolism in cancer	28/1034	134/7206	0.0341992438799
ko00630	Glyoxylate and dicarboxylate metabolism	1/1034	38/7206	0.0351571492637
ko03410	Base excision repair	1/1034	38/7206	0.0351571492637
ko04912	GnRH signaling pathway	26/1034	122/7206	0.0360020213936
ko05131	Shigellosis	5/1034	82/7206	0.0374163589969
ko04137	Mitophagy - animal	5/1034	82/7206	0.0374163589969
ko00230	Purine metabolism	38/1034	194/7206	0.038033140544
ko05219	Bladder cancer	2/1034	48/7206	0.0388447700563
ko04218	Cellular senescence	16/1034	177/7206	0.0392245988005
ko04062	Chemokine signaling pathway	39/1034	201/7206	0.0414096410118
ko04918	Thyroid hormone synthesis	19/1034	86/7206	0.0444487941175
ko05034	Alcoholism	45/1034	238/7206	0.0478640997703