ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 38/643 152/7206 2.54990175752e-09 ko04020 Calcium signaling pathway 50/643 265/7206 2.34450461433e-07 ko04725 Cholinergic synapse 35/643 160/7206 3.93139416759e-07 ko04713 Circadian entrainment 31/643 136/7206 7.09486673201e-07 ko04080 Neuroactive ligand-receptor interaction 67/643 423/7206 2.38405101924e-06 ko04070 Phosphatidylinositol signaling system 26/643 112/7206 3.91362064768e-06 ko05032 Morphine addiction 25/643 110/7206 8.95277373425e-06 ko04911 Insulin secretion 26/643 117/7206 9.16853355751e-06 ko04970 Salivary secretion 22/643 95/7206 2.24937752879e-05 ko04726 Serotonergic synapse 28/643 137/7206 2.4696313989e-05 ko04514 Cell adhesion molecules (CAMs) 27/643 130/7206 2.77166178551e-05 ko04727 GABAergic synapse 24/643 110/7206 2.78725813406e-05 ko03040 Spliceosome 1/643 145/7206 4.2020383763e-05 ko03010 Ribosome 1/643 129/7206 0.00012782668452 ko05322 Systemic lupus erythematosus 2/643 151/7206 0.000136314873789 ko04925 Aldosterone synthesis and secretion 22/643 105/7206 0.000164091464966 ko04744 Phototransduction 11/643 36/7206 0.000197323441053 ko05203 Viral carcinogenesis 9/643 277/7206 0.000229045590334 ko04710 Circadian rhythm 12/643 43/7206 0.00026460401375 ko04110 Cell cycle 2/643 145/7206 0.000301920876346 ko04141 Protein processing in endoplasmic reticulum 4/643 184/7206 0.000324693055503 ko04072 Phospholipase D signaling pathway 33/643 197/7206 0.000330266887831 ko04971 Gastric acid secretion 20/643 98/7206 0.000430981341932 ko04921 Oxytocin signaling pathway 34/643 209/7206 0.000489603367208 ko04022 cGMP-PKG signaling pathway 35/643 216/7206 0.000576662686224 ko04964 Proximal tubule bicarbonate reclamation 9/643 29/7206 0.000662806210436 ko04960 Aldosterone-regulated sodium reabsorption 11/643 41/7206 0.000686775310461 ko05033 Nicotine addiction 13/643 56/7206 0.00103436846135 ko04972 Pancreatic secretion 21/643 111/7206 0.00104095099203 ko05169 Epstein-Barr virus infection 6/643 206/7206 0.00108286808609 ko04014 Ras signaling pathway 41/643 279/7206 0.00121458350558 ko03013 RNA transport 4/643 166/7206 0.00129381973233 ko04728 Dopaminergic synapse 29/643 185/7206 0.00240849015783 ko05031 Amphetamine addiction 17/643 91/7206 0.00270294943631 ko04720 Long-term potentiation 18/643 99/7206 0.00357032467391 ko04730 Long-term depression 15/643 78/7206 0.00395712053613 ko04721 Synaptic vesicle cycle 15/643 80/7206 0.00478852726803 ko04024 cAMP signaling pathway 39/643 279/7206 0.00500547992032 ko04745 Phototransduction - fly 9/643 38/7206 0.00521574725221 ko04270 Vascular smooth muscle contraction 24/643 154/7206 0.00615211014478 ko04120 Ubiquitin mediated proteolysis 4/643 138/7206 0.009408034418 ko04723 Retrograde endocannabinoid signaling 26/643 175/7206 0.00991859100057 ko00230 Purine metabolism 28/643 194/7206 0.0101102766372 ko00562 Inositol phosphate metabolism 15/643 89/7206 0.0138363299166 ko00564 Glycerophospholipid metabolism 16/643 99/7206 0.0189889946283 ko04371 Apelin signaling pathway 25/643 177/7206 0.0220102618013 ko04924 Renin secretion 14/643 86/7206 0.0221332506781 ko04918 Thyroid hormone synthesis 14/643 86/7206 0.0221332506781 ko00592 alpha-Linolenic acid metabolism 5/643 19/7206 0.0225350315293 ko04711 Circadian rhythm - fly 4/643 13/7206 0.0233728574656 ko05168 Herpes simplex infection 8/643 182/7206 0.0251466820968 ko00120 Primary bile acid biosynthesis 5/643 20/7206 0.0279032178814 ko00760 Nicotinate and nicotinamide metabolism 7/643 34/7206 0.0279064357205 ko00680 Methane metabolism 7/643 34/7206 0.0279064357205 ko05230 Central carbon metabolism in cancer 13/643 81/7206 0.0306420490214 ko04261 Adrenergic signaling in cardiomyocytes 27/643 205/7206 0.0346558868054 ko00010 Glycolysis / Gluconeogenesis 12/643 74/7206 0.0376460754454 ko04919 Thyroid hormone signaling pathway 20/643 143/7206 0.0377412414838 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/643 59/7206 0.0382810804813 ko05213 Endometrial cancer 1/643 62/7206 0.0410465831723 ko00471 D-Glutamine and D-glutamate metabolism 2/643 4/7206 0.0422344561049 ko04672 Intestinal immune network for IgA production 7/643 37/7206 0.0424018497564 ko05224 Breast cancer 8/643 174/7206 0.042620972074 ko05130 Pathogenic Escherichia coli infection 2/643 77/7206 0.0446337204954 ko04612 Antigen processing and presentation 2/643 77/7206 0.0446337204954 ko00565 Ether lipid metabolism 8/643 42/7206 0.0494349787542