ko pathway ratio_in_study ratio_in_pop p_value ko04710 Circadian rhythm 15/539 43/7206 2.2468890089e-07 ko04070 Phosphatidylinositol signaling system 21/539 112/7206 6.89828597319e-05 ko04014 Ras signaling pathway 39/539 279/7206 0.000109968409262 ko03040 Spliceosome 1/539 145/7206 0.000314789441859 ko04919 Thyroid hormone signaling pathway 23/539 143/7206 0.000521784779367 ko04960 Aldosterone-regulated sodium reabsorption 10/539 41/7206 0.000678216056423 ko04360 Axon guidance 32/539 233/7206 0.000831264656694 ko04724 Glutamatergic synapse 23/539 152/7206 0.000940511012928 ko03010 Ribosome 1/539 129/7206 0.00100066452616 ko05032 Morphine addiction 18/539 110/7206 0.00140919723112 ko05322 Systemic lupus erythematosus 2/539 151/7206 0.00141307294143 ko04514 Cell adhesion molecules (CAMs) 20/539 130/7206 0.00191538389346 ko05230 Central carbon metabolism in cancer 14/539 81/7206 0.00246957600358 ko04922 Glucagon signaling pathway 19/539 128/7206 0.00343107756331 ko04911 Insulin secretion 18/539 117/7206 0.00361152616045 ko04727 GABAergic synapse 17/539 110/7206 0.00492570100482 ko04020 Calcium signaling pathway 32/539 265/7206 0.00599743806932 ko04930 Type II diabetes mellitus 10/539 54/7206 0.00601422550526 ko04745 Phototransduction - fly 8/539 38/7206 0.00612679702705 ko03013 RNA transport 4/539 166/7206 0.00696942341408 ko04713 Circadian entrainment 19/539 136/7206 0.00749863422411 ko05033 Nicotine addiction 10/539 56/7206 0.00782407252831 ko04725 Cholinergic synapse 21/539 160/7206 0.0095242281656 ko05203 Viral carcinogenesis 10/539 277/7206 0.00995742482116 ko00680 Methane metabolism 7/539 34/7206 0.0114814523046 ko00120 Primary bile acid biosynthesis 5/539 20/7206 0.01388451371 ko00240 Pyrimidine metabolism 2/539 110/7206 0.0165048565705 ko04964 Proximal tubule bicarbonate reclamation 6/539 29/7206 0.0183934433328 ko04657 IL-17 signaling pathway 1/539 87/7206 0.0210597385982 ko04152 AMPK signaling pathway 20/539 161/7206 0.0221416147391 ko00562 Inositol phosphate metabolism 13/539 89/7206 0.0223079105392 ko00010 Glycolysis / Gluconeogenesis 11/539 74/7206 0.0238711774899 ko05031 Amphetamine addiction 13/539 91/7206 0.0240511282063 ko04066 HIF-1 signaling pathway 16/539 123/7206 0.0244644709093 ko04110 Cell cycle 4/539 145/7206 0.0246451618532 ko05130 Pathogenic Escherichia coli infection 1/539 77/7206 0.0290274446614 ko00471 D-Glutamine and D-glutamate metabolism 2/539 4/7206 0.0302737732901 ko00290 Valine, leucine and isoleucine biosynthesis 2/539 4/7206 0.0302737732901 ko04728 Dopaminergic synapse 22/539 185/7206 0.0319675320505 ko04068 FoxO signaling pathway 20/539 167/7206 0.0354581365955 ko04925 Aldosterone synthesis and secretion 14/539 105/7206 0.0363836124852 ko04626 Plant-pathogen interaction 4/539 18/7206 0.040828156672 ko04024 cAMP signaling pathway 30/539 279/7206 0.0471846911655 ko05214 Glioma 11/539 79/7206 0.0476789124742 ko04744 Phototransduction 6/539 36/7206 0.0485808954022 ko00592 alpha-Linolenic acid metabolism 4/539 19/7206 0.0487611334012 ko04740 Olfactory transduction 11/539 80/7206 0.0493875585685