ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	215/1418	423/7206	6.81265226e-50
ko04724	Glutamatergic synapse	93/1418	152/7206	8.58569304654e-30
ko05033	Nicotine addiction	48/1418	56/7206	1.82321412168e-26
ko05032	Morphine addiction	72/1418	110/7206	6.54416744092e-26
ko04713	Circadian entrainment	79/1418	136/7206	2.27898964739e-23
ko04727	GABAergic synapse	69/1418	110/7206	2.89101807923e-23
ko04020	Calcium signaling pathway	116/1418	265/7206	8.60652416798e-20
ko04721	Synaptic vesicle cycle	52/1418	80/7206	7.86376532871e-19
ko04725	Cholinergic synapse	80/1418	160/7206	3.39131253924e-18
ko04728	Dopaminergic synapse	88/1418	185/7206	5.50136954144e-18
ko04723	Retrograde endocannabinoid signaling	81/1418	175/7206	6.99861952666e-16
ko04024	cAMP signaling pathway	111/1418	279/7206	2.88859297089e-15
ko04726	Serotonergic synapse	65/1418	137/7206	1.94543980655e-13
ko04911	Insulin secretion	58/1418	117/7206	2.55378722756e-13
ko04921	Oxytocin signaling pathway	86/1418	209/7206	5.91169960604e-13
ko04744	Phototransduction	26/1418	36/7206	1.17919834463e-11
ko04742	Taste transduction	36/1418	61/7206	1.31139708563e-11
ko03010	Ribosome	1/1418	129/7206	2.54556392129e-11
ko04970	Salivary secretion	47/1418	95/7206	5.29879377699e-11
ko03040	Spliceosome	3/1418	145/7206	2.17831478768e-10
ko04022	cGMP-PKG signaling pathway	82/1418	216/7206	2.757001542e-10
ko04261	Adrenergic signaling in cardiomyocytes	77/1418	205/7206	1.82859885583e-09
ko05031	Amphetamine addiction	43/1418	91/7206	2.19824429829e-09
ko05322	Systemic lupus erythematosus	5/1418	151/7206	4.68265849297e-09
ko04720	Long-term potentiation	44/1418	99/7206	2.33596293965e-08
ko03013	RNA transport	8/1418	166/7206	4.96572299218e-08
ko05203	Viral carcinogenesis	22/1418	277/7206	4.99054568137e-08
ko04971	Gastric acid secretion	42/1418	98/7206	1.24381718137e-07
ko04925	Aldosterone synthesis and secretion	44/1418	105/7206	1.57198883084e-07
ko04966	Collecting duct acid secretion	17/1418	26/7206	4.63396765966e-07
ko05168	Herpes simplex infection	12/1418	182/7206	9.87800329334e-07
ko04110	Cell cycle	8/1418	145/7206	1.40601778381e-06
ko04740	Olfactory transduction	34/1418	80/7206	2.76305264645e-06
ko04070	Phosphatidylinositol signaling system	43/1418	112/7206	3.49119794063e-06
ko04141	Protein processing in endoplasmic reticulum	14/1418	184/7206	7.70522696206e-06
ko03008	Ribosome biogenesis in eukaryotes	2/1418	79/7206	1.08552383608e-05
ko04270	Vascular smooth muscle contraction	53/1418	154/7206	1.32870298508e-05
ko04972	Pancreatic secretion	41/1418	111/7206	1.86613621144e-05
ko05030	Cocaine addiction	30/1418	73/7206	2.19931351851e-05
ko04745	Phototransduction - fly	19/1418	38/7206	2.58849438336e-05
ko04730	Long-term depression	31/1418	78/7206	3.92093823365e-05
ko05164	Influenza A	14/1418	167/7206	7.06719037456e-05
ko04976	Bile secretion	31/1418	80/7206	8.95797512217e-05
ko04371	Apelin signaling pathway	56/1418	177/7206	0.000117457200396
ko05169	Epstein-Barr virus infection	20/1418	206/7206	0.000117776597469
ko04072	Phospholipase D signaling pathway	61/1418	197/7206	0.00012267840479
ko00520	Amino sugar and nucleotide sugar metabolism	1/1418	55/7206	0.000122747454744
ko04010	MAPK signaling pathway	91/1418	321/7206	0.000130944557735
ko04924	Renin secretion	32/1418	86/7206	0.000166828699943
ko04540	Gap junction	43/1418	128/7206	0.000180089090916
ko04014	Ras signaling pathway	80/1418	279/7206	0.000214890810166
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1418	74/7206	0.000305901005463
ko04360	Axon guidance	68/1418	233/7206	0.000403409534314
ko04964	Proximal tubule bicarbonate reclamation	14/1418	29/7206	0.000481473475707
ko04750	Inflammatory mediator regulation of TRP channels	40/1418	122/7206	0.000514760216701
ko04514	Cell adhesion molecules (CAMs)	42/1418	130/7206	0.000518531568471
ko05161	Hepatitis B	17/1418	173/7206	0.000636326498432
ko05110	Vibrio cholerae infection	24/1418	63/7206	0.000646251144774
ko04621	NOD-like receptor signaling pathway	15/1418	157/7206	0.000740539569577
ko04710	Circadian rhythm	18/1418	43/7206	0.000772645838865
ko04060	Cytokine-cytokine receptor interaction	20/1418	191/7206	0.0008259111221
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1418	79/7206	0.000916739743884
ko05162	Measles	10/1418	120/7206	0.00104465787242
ko03420	Nucleotide excision repair	1/1418	46/7206	0.00110702230853
ko04923	Regulation of lipolysis in adipocytes	27/1418	77/7206	0.00135070812102
ko05133	Pertussis	6/1418	87/7206	0.0015549240203
ko04120	Ubiquitin mediated proteolysis	13/1418	138/7206	0.00156487510991
ko05414	Dilated cardiomyopathy	36/1418	112/7206	0.00165910718917
ko03022	Basal transcription factors	1/1418	44/7206	0.00170786413245
ko04622	RIG-I-like receptor signaling pathway	3/1418	62/7206	0.00186408191774
ko04260	Cardiac muscle contraction	32/1418	98/7206	0.00201012082223
ko04930	Type II diabetes mellitus	20/1418	54/7206	0.00290439186871
ko05131	Shigellosis	6/1418	82/7206	0.00301671389638
ko04922	Glucagon signaling pathway	39/1418	128/7206	0.00330959529953
ko03410	Base excision repair	1/1418	38/7206	0.00371309398672
ko05205	Proteoglycans in cancer	35/1418	271/7206	0.00383332207537
ko04657	IL-17 signaling pathway	7/1418	87/7206	0.00408885692609
ko04214	Apoptosis - fly	5/1418	72/7206	0.00421745300928
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1418	59/7206	0.00443223257386
ko00562	Inositol phosphate metabolism	28/1418	89/7206	0.00708683938029
ko04217	Necroptosis	21/1418	178/7206	0.00721963772789
ko04630	Jak-STAT signaling pathway	14/1418	132/7206	0.00759559669155
ko00240	Pyrimidine metabolism	11/1418	110/7206	0.00768707929622
ko05140	Leishmaniasis	6/1418	75/7206	0.00810020611183
ko04960	Aldosterone-regulated sodium reabsorption	15/1418	41/7206	0.00996461504881
ko05145	Toxoplasmosis	14/1418	126/7206	0.0126536586474
ko05166	HTLV-I infection	41/1418	292/7206	0.0129713271886
ko04626	Plant-pathogen interaction	8/1418	18/7206	0.0146731258525
ko04113	Meiosis - yeast	6/1418	70/7206	0.0153738070791
ko05416	Viral myocarditis	4/1418	55/7206	0.0166014653145
ko05219	Bladder cancer	3/1418	48/7206	0.0166039914773
ko05321	Inflammatory bowel disease (IBD)	4/1418	56/7206	0.0168454217917
ko04973	Carbohydrate digestion and absorption	15/1418	42/7206	0.0172442029428
ko04210	Apoptosis	23/1418	180/7206	0.0173722513855
ko03018	RNA degradation	8/1418	84/7206	0.0180845416284
ko04915	Estrogen signaling pathway	37/1418	131/7206	0.0191799281156
ko04658	Th1 and Th2 cell differentiation	10/1418	96/7206	0.0196220206649
ko04064	NF-kappa B signaling pathway	10/1418	96/7206	0.0196220206649
ko04612	Antigen processing and presentation	7/1418	77/7206	0.0199633685081
ko05217	Basal cell carcinoma	6/1418	68/7206	0.0210387760835
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1418	100/7206	0.0223613818538
ko05144	Malaria	3/1418	45/7206	0.0236090764074
ko00280	Valine, leucine and isoleucine degradation	4/1418	54/7206	0.0238268687001
ko04711	Circadian rhythm - fly	6/1418	13/7206	0.0277484960939
ko04620	Toll-like receptor signaling pathway	11/1418	100/7206	0.0303540168278
ko05016	Huntington's disease	30/1418	215/7206	0.0361146731309
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1418	14/7206	0.0406586218202
ko05202	Transcriptional misregulation in cancer	26/1418	188/7206	0.0407948487131
ko04146	Peroxisome	10/1418	89/7206	0.043949586471
ko04350	TGF-beta signaling pathway	12/1418	103/7206	0.0447347749081
ko04520	Adherens junction	12/1418	103/7206	0.0447347749081
ko04142	Lysosome	20/1418	151/7206	0.0487567681664
ko00860	Porphyrin and chlorophyll metabolism	2/1418	34/7206	0.0488453545393
ko04912	GnRH signaling pathway	33/1418	122/7206	0.0499172464984