ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 25/387 80/7206 1.97865786158e-13 ko05033 Nicotine addiction 19/387 56/7206 3.25385240728e-11 ko04727 GABAergic synapse 24/387 110/7206 2.41950361446e-09 ko04024 cAMP signaling pathway 39/387 279/7206 2.49756003904e-08 ko04080 Neuroactive ligand-receptor interaction 51/387 423/7206 3.81285758991e-08 ko04911 Insulin secretion 23/387 117/7206 4.27180443986e-08 ko04723 Retrograde endocannabinoid signaling 28/387 175/7206 1.52657969503e-07 ko05032 Morphine addiction 21/387 110/7206 2.82063336131e-07 ko04724 Glutamatergic synapse 25/387 152/7206 4.21145020437e-07 ko04728 Dopaminergic synapse 26/387 185/7206 5.33659219617e-06 ko04725 Cholinergic synapse 22/387 160/7206 4.02208334689e-05 ko04964 Proximal tubule bicarbonate reclamation 8/387 29/7206 0.000101870433425 ko04360 Axon guidance 27/387 233/7206 0.000148964833732 ko05203 Viral carcinogenesis 3/387 277/7206 0.000317481289511 ko04713 Circadian entrainment 18/387 136/7206 0.000326196781361 ko04921 Oxytocin signaling pathway 23/387 209/7206 0.000893099147227 ko04071 Sphingolipid signaling pathway 19/387 162/7206 0.00115327276178 ko04010 MAPK signaling pathway 31/387 321/7206 0.00134794939783 ko05169 Epstein-Barr virus infection 2/387 206/7206 0.00146869066994 ko04970 Salivary secretion 13/387 95/7206 0.00158627956982 ko04144 Endocytosis 32/387 342/7206 0.00190934865071 ko04971 Gastric acid secretion 13/387 98/7206 0.00211149945489 ko04966 Collecting duct acid secretion 6/387 26/7206 0.00212179858966 ko04261 Adrenergic signaling in cardiomyocytes 22/387 205/7206 0.00228223525672 ko04720 Long-term potentiation 13/387 99/7206 0.00231551913148 ko04744 Phototransduction 7/387 36/7206 0.00262877426151 ko04060 Cytokine-cytokine receptor interaction 2/387 191/7206 0.00301201782144 ko04726 Serotonergic synapse 16/387 137/7206 0.00312263820463 ko04072 Phospholipase D signaling pathway 21/387 197/7206 0.00322879039901 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/387 59/7206 0.00390022251089 ko04742 Taste transduction 9/387 61/7206 0.00489781571789 ko05322 Systemic lupus erythematosus 1/387 151/7206 0.00504924571013 ko05030 Cocaine addiction 10/387 73/7206 0.0053150606698 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/387 14/7206 0.00533150055915 ko04960 Aldosterone-regulated sodium reabsorption 7/387 41/7206 0.00562091218018 ko05110 Vibrio cholerae infection 9/387 63/7206 0.00608309792628 ko04120 Ubiquitin mediated proteolysis 1/387 138/7206 0.00694362785036 ko04130 SNARE interactions in vesicular transport 7/387 44/7206 0.00834647390026 ko04972 Pancreatic secretion 13/387 111/7206 0.00836614742579 ko04730 Long-term depression 10/387 78/7206 0.0084901697746 ko05031 Amphetamine addiction 11/387 91/7206 0.00915380078913 ko03013 RNA transport 2/387 166/7206 0.0129573933232 ko04925 Aldosterone synthesis and secretion 12/387 105/7206 0.0131736191085 ko01200 Carbon metabolism 1/387 128/7206 0.0152234718806 ko05120 Epithelial cell signaling in Helicobacter pylori infection 11/387 92/7206 0.0159382072204 ko04070 Phosphatidylinositol signaling system 12/387 112/7206 0.018581307172 ko04923 Regulation of lipolysis in adipocytes 9/387 77/7206 0.0215126088943 ko04973 Carbohydrate digestion and absorption 6/387 42/7206 0.0234925707755 ko03040 Spliceosome 2/387 145/7206 0.0244593801182 ko04924 Renin secretion 10/387 86/7206 0.0247947614343 ko04022 cGMP-PKG signaling pathway 19/387 216/7206 0.0307835705235 ko05164 Influenza A 3/387 167/7206 0.0355014442746 ko04020 Calcium signaling pathway 22/387 265/7206 0.0368551041237 ko04976 Bile secretion 9/387 80/7206 0.0386741564615 ko04666 Fc gamma R-mediated phagocytosis 12/387 122/7206 0.0393459602957 ko04015 Rap1 signaling pathway 23/387 278/7206 0.0401271444471 ko02024 Quorum sensing 3/387 15/7206 0.0432018214237 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/387 15/7206 0.0432018214237 ko05016 Huntington's disease 5/387 215/7206 0.0444378788717 ko04141 Protein processing in endoplasmic reticulum 4/387 184/7206 0.0468129295581 ko04918 Thyroid hormone synthesis 9/387 86/7206 0.0487948341329