ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 172/1061 423/7206 1.65873826502e-41 ko04724 Glutamatergic synapse 80/1061 152/7206 1.55738782056e-28 ko05033 Nicotine addiction 42/1061 56/7206 4.03442870044e-24 ko04713 Circadian entrainment 65/1061 136/7206 2.10118088999e-20 ko04020 Calcium signaling pathway 97/1061 265/7206 1.91192860659e-19 ko04728 Dopaminergic synapse 76/1061 185/7206 8.79234768326e-19 ko05032 Morphine addiction 55/1061 110/7206 1.39920470389e-18 ko04727 GABAergic synapse 52/1061 110/7206 2.68255880988e-16 ko04725 Cholinergic synapse 65/1061 160/7206 6.24213171282e-16 ko04024 cAMP signaling pathway 91/1061 279/7206 1.70358098643e-14 ko04911 Insulin secretion 51/1061 117/7206 3.2095867186e-14 ko04723 Retrograde endocannabinoid signaling 65/1061 175/7206 1.03259027646e-13 ko04721 Synaptic vesicle cycle 39/1061 80/7206 4.40921962426e-13 ko04726 Serotonergic synapse 54/1061 137/7206 8.39414240114e-13 ko04921 Oxytocin signaling pathway 70/1061 209/7206 5.3359169605e-12 ko05031 Amphetamine addiction 38/1061 91/7206 2.95141455427e-10 ko04742 Taste transduction 29/1061 61/7206 9.78638293114e-10 ko04720 Long-term potentiation 38/1061 99/7206 5.17975037249e-09 ko04970 Salivary secretion 36/1061 95/7206 1.95290328118e-08 ko04925 Aldosterone synthesis and secretion 38/1061 105/7206 3.4029609995e-08 ko03040 Spliceosome 2/1061 145/7206 4.1005175568e-08 ko03010 Ribosome 1/1061 129/7206 4.57145638971e-08 ko04261 Adrenergic signaling in cardiomyocytes 60/1061 205/7206 6.06965773896e-08 ko04022 cGMP-PKG signaling pathway 61/1061 216/7206 2.34419498782e-07 ko04070 Phosphatidylinositol signaling system 38/1061 112/7206 2.55790332617e-07 ko04971 Gastric acid secretion 34/1061 98/7206 7.18485886716e-07 ko05322 Systemic lupus erythematosus 4/1061 151/7206 1.14480925791e-06 ko05030 Cocaine addiction 27/1061 73/7206 2.02529760409e-06 ko04744 Phototransduction 17/1061 36/7206 3.39257640922e-06 ko04745 Phototransduction - fly 17/1061 38/7206 8.47852288822e-06 ko05168 Herpes simplex infection 8/1061 182/7206 1.04472768443e-05 ko04730 Long-term depression 27/1061 78/7206 1.24066272978e-05 ko04072 Phospholipase D signaling pathway 52/1061 197/7206 1.43816812449e-05 ko05164 Influenza A 7/1061 167/7206 1.95237334829e-05 ko04710 Circadian rhythm 17/1061 43/7206 5.98387890243e-05 ko05203 Viral carcinogenesis 19/1061 277/7206 6.10352124219e-05 ko04750 Inflammatory mediator regulation of TRP channels 35/1061 122/7206 7.86266788781e-05 ko03013 RNA transport 8/1061 166/7206 8.29368348086e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 24/1061 74/7206 9.72724001569e-05 ko04014 Ras signaling pathway 64/1061 279/7206 0.000191573628277 ko05169 Epstein-Barr virus infection 13/1061 206/7206 0.000203061487995 ko04922 Glucagon signaling pathway 35/1061 128/7206 0.000203569218519 ko04110 Cell cycle 7/1061 145/7206 0.000207748326674 ko04621 NOD-like receptor signaling pathway 8/1061 157/7206 0.000221441685785 ko04514 Cell adhesion molecules (CAMs) 35/1061 130/7206 0.000243699448638 ko04972 Pancreatic secretion 31/1061 111/7206 0.000345006473607 ko04740 Olfactory transduction 24/1061 80/7206 0.000385502170651 ko04010 MAPK signaling pathway 70/1061 321/7206 0.000496667874889 ko04120 Ubiquitin mediated proteolysis 7/1061 138/7206 0.000576895371538 ko03008 Ribosome biogenesis in eukaryotes 2/1061 79/7206 0.000626589297163 ko04141 Protein processing in endoplasmic reticulum 12/1061 184/7206 0.000695007373276 ko05140 Leishmaniasis 2/1061 75/7206 0.000919012947023 ko04540 Gap junction 33/1061 128/7206 0.000927879773083 ko04924 Renin secretion 24/1061 86/7206 0.00178840047987 ko04360 Axon guidance 52/1061 233/7206 0.0017937827672 ko05161 Hepatitis B 12/1061 173/7206 0.00220303065322 ko00562 Inositol phosphate metabolism 24/1061 89/7206 0.00230334747745 ko04626 Plant-pathogen interaction 8/1061 18/7206 0.00237627896667 ko04371 Apelin signaling pathway 41/1061 177/7206 0.00245914254441 ko04060 Cytokine-cytokine receptor interaction 14/1061 191/7206 0.00250463765862 ko04612 Antigen processing and presentation 3/1061 77/7206 0.0034077108062 ko05162 Measles 7/1061 120/7206 0.00387952047193 ko04064 NF-kappa B signaling pathway 5/1061 96/7206 0.00539304642697 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/1061 79/7206 0.00582638054902 ko04915 Estrogen signaling pathway 31/1061 131/7206 0.00584608055305 ko04960 Aldosterone-regulated sodium reabsorption 13/1061 41/7206 0.00596359868731 ko05219 Bladder cancer 1/1061 48/7206 0.00712909140824 ko04630 Jak-STAT signaling pathway 9/1061 132/7206 0.00863344813506 ko04966 Collecting duct acid secretion 9/1061 26/7206 0.00927368664621 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1061 14/7206 0.0104576433125 ko05144 Malaria 1/1061 45/7206 0.0106221329172 ko03420 Nucleotide excision repair 1/1061 46/7206 0.0107316907992 ko04930 Type II diabetes mellitus 15/1061 54/7206 0.0111906411232 ko04217 Necroptosis 15/1061 178/7206 0.0136273079935 ko05205 Proteoglycans in cancer 26/1061 271/7206 0.0141561175687 ko04657 IL-17 signaling pathway 5/1061 87/7206 0.0141601054963 ko05133 Pertussis 5/1061 87/7206 0.0141601054963 ko05130 Pathogenic Escherichia coli infection 4/1061 77/7206 0.0143824186496 ko05145 Toxoplasmosis 9/1061 126/7206 0.0151294833898 ko03022 Basal transcription factors 1/1061 44/7206 0.0163950166933 ko05230 Central carbon metabolism in cancer 20/1061 81/7206 0.0168666586484 ko05166 HTLV-I infection 29/1061 292/7206 0.0179449493124 ko05231 Choline metabolism in cancer 30/1061 134/7206 0.0184810699953 ko00280 Valine, leucine and isoleucine degradation 2/1061 54/7206 0.0188959538131 ko04015 Rap1 signaling pathway 55/1061 278/7206 0.0194308055732 ko04260 Cardiac muscle contraction 23/1061 98/7206 0.020547885647 ko04270 Vascular smooth muscle contraction 33/1061 154/7206 0.0213560333828 ko04214 Apoptosis - fly 4/1061 72/7206 0.0280159646591 ko04330 Notch signaling pathway 3/1061 62/7206 0.0285746971798 ko04622 RIG-I-like receptor signaling pathway 3/1061 62/7206 0.0285746971798 ko04964 Proximal tubule bicarbonate reclamation 9/1061 29/7206 0.0295152607986 ko04711 Circadian rhythm - fly 5/1061 13/7206 0.0316400933436 ko03410 Base excision repair 1/1061 38/7206 0.0354768939459 ko04610 Complement and coagulation cascades 5/1061 79/7206 0.0363013090217 ko05016 Huntington's disease 21/1061 215/7206 0.0396109312532 ko04658 Th1 and Th2 cell differentiation 7/1061 96/7206 0.0410723482458 ko04973 Carbohydrate digestion and absorption 11/1061 42/7206 0.0468098069154 ko05110 Vibrio cholerae infection 15/1061 63/7206 0.0487545928954