ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1171	423/7206	3.8600063689e-49
ko04724	Glutamatergic synapse	91/1171	152/7206	6.79011783408e-35
ko05033	Nicotine addiction	50/1171	56/7206	1.71067062026e-33
ko05032	Morphine addiction	69/1171	110/7206	1.99845846043e-28
ko04713	Circadian entrainment	77/1171	136/7206	2.18703048037e-27
ko04727	GABAergic synapse	67/1171	110/7206	1.5467694929e-26
ko04728	Dopaminergic synapse	86/1171	185/7206	1.4614723747e-22
ko04721	Synaptic vesicle cycle	51/1171	80/7206	9.2788992677e-22
ko04725	Cholinergic synapse	74/1171	160/7206	2.17285455284e-19
ko04723	Retrograde endocannabinoid signaling	77/1171	175/7206	1.54319089058e-18
ko04024	cAMP signaling pathway	104/1171	279/7206	3.61320595624e-18
ko04020	Calcium signaling pathway	96/1171	265/7206	6.89729532255e-16
ko04726	Serotonergic synapse	61/1171	137/7206	3.22346742195e-15
ko04744	Phototransduction	27/1171	36/7206	8.0404643175e-15
ko04911	Insulin secretion	54/1171	117/7206	2.03019093324e-14
ko04742	Taste transduction	35/1171	61/7206	2.45906509614e-13
ko05031	Amphetamine addiction	44/1171	91/7206	7.25079105569e-13
ko04921	Oxytocin signaling pathway	74/1171	209/7206	6.57060227664e-12
ko04720	Long-term potentiation	44/1171	99/7206	2.67397879991e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1171	205/7206	2.47853116785e-10
ko03040	Spliceosome	2/1171	145/7206	4.0253170826e-09
ko03010	Ribosome	1/1171	129/7206	4.09185967276e-09
ko04970	Salivary secretion	39/1171	95/7206	5.97055880257e-09
ko05030	Cocaine addiction	32/1171	73/7206	2.11153738345e-08
ko04070	Phosphatidylinositol signaling system	42/1171	112/7206	3.91739862978e-08
ko04925	Aldosterone synthesis and secretion	39/1171	105/7206	1.60697841823e-07
ko05203	Viral carcinogenesis	17/1171	277/7206	4.47396457594e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1171	74/7206	4.72777775222e-07
ko05322	Systemic lupus erythematosus	5/1171	151/7206	5.9043309668e-07
ko04971	Gastric acid secretion	36/1171	98/7206	6.55536298178e-07
ko04360	Axon guidance	67/1171	233/7206	1.21192923557e-06
ko04060	Cytokine-cytokine receptor interaction	9/1171	191/7206	1.21480204696e-06
ko03013	RNA transport	7/1171	166/7206	1.88977758873e-06
ko04022	cGMP-PKG signaling pathway	62/1171	216/7206	3.25566485588e-06
ko04740	Olfactory transduction	30/1171	80/7206	3.93338777253e-06
ko04072	Phospholipase D signaling pathway	57/1171	197/7206	5.24556636958e-06
ko04621	NOD-like receptor signaling pathway	7/1171	157/7206	8.34906008306e-06
ko04141	Protein processing in endoplasmic reticulum	10/1171	184/7206	1.02573313406e-05
ko04514	Cell adhesion molecules (CAMs)	41/1171	130/7206	1.14649511582e-05
ko04010	MAPK signaling pathway	81/1171	321/7206	2.5529790526e-05
ko05168	Herpes simplex infection	11/1171	182/7206	3.9323317184e-05
ko04966	Collecting duct acid secretion	13/1171	26/7206	6.68051323137e-05
ko05164	Influenza A	10/1171	167/7206	7.47173917407e-05
ko04972	Pancreatic secretion	34/1171	111/7206	0.000133496397638
ko04745	Phototransduction - fly	16/1171	38/7206	0.000134127149203
ko04110	Cell cycle	8/1171	145/7206	0.000141264001063
ko04730	Long-term depression	26/1171	78/7206	0.000164858219917
ko04610	Complement and coagulation cascades	2/1171	79/7206	0.000171795393205
ko03008	Ribosome biogenesis in eukaryotes	2/1171	79/7206	0.000171795393205
ko04612	Antigen processing and presentation	2/1171	77/7206	0.000257843931241
ko04120	Ubiquitin mediated proteolysis	8/1171	138/7206	0.000267958162046
ko04711	Circadian rhythm - fly	8/1171	13/7206	0.000283512025745
ko05169	Epstein-Barr virus infection	16/1171	206/7206	0.000368319266092
ko04064	NF-kappa B signaling pathway	4/1171	96/7206	0.000404453502869
ko04915	Estrogen signaling pathway	37/1171	131/7206	0.000456855794118
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1171	79/7206	0.000595271460305
ko04540	Gap junction	36/1171	128/7206	0.000615594573499
ko05110	Vibrio cholerae infection	21/1171	63/7206	0.000811762602011
ko04626	Plant-pathogen interaction	9/1171	18/7206	0.000920775219206
ko00240	Pyrimidine metabolism	6/1171	110/7206	0.000971214334216
ko05205	Proteoglycans in cancer	25/1171	271/7206	0.000996794965601
ko04924	Renin secretion	26/1171	86/7206	0.00103767794779
ko00520	Amino sugar and nucleotide sugar metabolism	1/1171	55/7206	0.00134635975921
ko05414	Dilated cardiomyopathy	31/1171	112/7206	0.00182249823675
ko00590	Arachidonic acid metabolism	1/1171	52/7206	0.00198781661455
ko04014	Ras signaling pathway	65/1171	279/7206	0.00208660577309
ko04260	Cardiac muscle contraction	28/1171	98/7206	0.00209222663492
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1171	59/7206	0.00214019491171
ko04930	Type II diabetes mellitus	18/1171	54/7206	0.00228780031736
ko05162	Measles	8/1171	120/7206	0.00252814664238
ko04750	Inflammatory mediator regulation of TRP channels	33/1171	122/7206	0.00265724094424
ko04923	Regulation of lipolysis in adipocytes	23/1171	77/7206	0.00268763038367
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1171	14/7206	0.00350949452053
ko04630	Jak-STAT signaling pathway	10/1171	132/7206	0.00414744047583
ko03420	Nucleotide excision repair	1/1171	46/7206	0.00443452186718
ko05161	Hepatitis B	15/1171	173/7206	0.00467002051958
ko00562	Inositol phosphate metabolism	25/1171	89/7206	0.00533846269253
ko05321	Inflammatory bowel disease (IBD)	2/1171	56/7206	0.00571635074523
ko04350	TGF-beta signaling pathway	7/1171	103/7206	0.00665881441403
ko03022	Basal transcription factors	1/1171	44/7206	0.00668299992021
ko04115	p53 signaling pathway	4/1171	74/7206	0.00687546685644
ko05140	Leishmaniasis	4/1171	75/7206	0.00688244691926
ko05144	Malaria	1/1171	45/7206	0.0069221203072
ko00071	Fatty acid degradation	1/1171	45/7206	0.0069221203072
ko00480	Glutathione metabolism	2/1171	55/7206	0.00877034224012
ko04912	GnRH signaling pathway	31/1171	122/7206	0.00885880839559
ko04976	Bile secretion	22/1171	80/7206	0.00921888895725
ko04622	RIG-I-like receptor signaling pathway	3/1171	62/7206	0.00929005919124
ko00310	Lysine degradation	4/1171	73/7206	0.00978895628097
ko05145	Toxoplasmosis	10/1171	126/7206	0.00991530578313
ko04210	Apoptosis	17/1171	180/7206	0.0103076000277
ko04710	Circadian rhythm	14/1171	43/7206	0.0107065765918
ko05202	Transcriptional misregulation in cancer	18/1171	188/7206	0.0118305296796
ko05231	Choline metabolism in cancer	33/1171	134/7206	0.0124315345144
ko04146	Peroxisome	6/1171	89/7206	0.0130539185012
ko03320	PPAR signaling pathway	4/1171	69/7206	0.0135187725642
ko03410	Base excision repair	1/1171	38/7206	0.0149555553307
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1171	40/7206	0.0155632128528
ko04658	Th1 and Th2 cell differentiation	7/1171	96/7206	0.016837187249
ko05133	Pertussis	6/1171	87/7206	0.01807259247
ko04964	Proximal tubule bicarbonate reclamation	10/1171	29/7206	0.0185692188199
ko04062	Chemokine signaling pathway	45/1171	201/7206	0.019840884912
ko04510	Focal adhesion	26/1171	240/7206	0.0203614961254
ko04722	Neurotrophin signaling pathway	37/1171	160/7206	0.0223274547205
ko04217	Necroptosis	18/1171	178/7206	0.0233209884108
ko05131	Shigellosis	6/1171	82/7206	0.0236924923652
ko05016	Huntington's disease	23/1171	215/7206	0.0240457567068
ko03018	RNA degradation	6/1171	84/7206	0.0242494349657
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1171	15/7206	0.0242706460535
ko05166	HTLV-I infection	34/1171	292/7206	0.0286471886197
ko05222	Small cell lung cancer	7/1171	89/7206	0.0294441792312
ko04113	Meiosis - yeast	5/1171	70/7206	0.0343307607286
ko00500	Starch and sucrose metabolism	1/1171	35/7206	0.0347288856181
ko04214	Apoptosis - fly	5/1171	72/7206	0.035046680179
ko04012	ErbB signaling pathway	26/1171	109/7206	0.0359122877203
ko04973	Carbohydrate digestion and absorption	12/1171	42/7206	0.036436936455
ko04657	IL-17 signaling pathway	7/1171	87/7206	0.0394023669247
ko00512	Mucin type O-glycan biosynthesis	9/1171	29/7206	0.0412420098724
ko05034	Alcoholism	50/1171	238/7206	0.0489770705554