ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1177	423/7206	1.75050436894e-54
ko04724	Glutamatergic synapse	90/1177	152/7206	8.3921195028e-34
ko05033	Nicotine addiction	49/1177	56/7206	8.45736752517e-32
ko05032	Morphine addiction	67/1177	110/7206	2.10962869365e-26
ko04727	GABAergic synapse	65/1177	110/7206	1.38089694037e-24
ko04713	Circadian entrainment	73/1177	136/7206	6.17836646598e-24
ko04721	Synaptic vesicle cycle	50/1177	80/7206	1.07256279393e-20
ko04728	Dopaminergic synapse	82/1177	185/7206	8.90215815712e-20
ko04725	Cholinergic synapse	73/1177	160/7206	1.36063232215e-18
ko04024	cAMP signaling pathway	105/1177	279/7206	1.66514597428e-18
ko04723	Retrograde endocannabinoid signaling	76/1177	175/7206	8.88457436497e-18
ko04744	Phototransduction	28/1177	36/7206	5.5757251503e-16
ko04020	Calcium signaling pathway	96/1177	265/7206	1.33967935564e-15
ko04726	Serotonergic synapse	59/1177	137/7206	7.25913160665e-14
ko04742	Taste transduction	35/1177	61/7206	2.87586987624e-13
ko04911	Insulin secretion	52/1177	117/7206	5.00143515195e-13
ko04921	Oxytocin signaling pathway	75/1177	209/7206	3.05960438685e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1177	205/7206	3.30533088764e-11
ko05031	Amphetamine addiction	41/1177	91/7206	8.92159056231e-11
ko04720	Long-term potentiation	42/1177	99/7206	5.3757963887e-10
ko03040	Spliceosome	2/1177	145/7206	4.10643688779e-09
ko03010	Ribosome	1/1177	129/7206	4.12293756081e-09
ko05203	Viral carcinogenesis	14/1177	277/7206	6.73268325692e-09
ko04970	Salivary secretion	39/1177	95/7206	6.92882097162e-09
ko05168	Herpes simplex infection	7/1177	182/7206	2.14039472965e-07
ko04060	Cytokine-cytokine receptor interaction	8/1177	191/7206	2.50129803271e-07
ko04740	Olfactory transduction	32/1177	80/7206	3.20187920644e-07
ko05030	Cocaine addiction	30/1177	73/7206	3.72200701245e-07
ko04925	Aldosterone synthesis and secretion	38/1177	105/7206	6.87146292652e-07
ko04022	cGMP-PKG signaling pathway	63/1177	216/7206	1.43619657373e-06
ko04070	Phosphatidylinositol signaling system	39/1177	112/7206	1.6929035531e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1177	74/7206	1.87920329369e-06
ko03013	RNA transport	7/1177	166/7206	1.90723768401e-06
ko05322	Systemic lupus erythematosus	6/1177	151/7206	3.32008537716e-06
ko04621	NOD-like receptor signaling pathway	7/1177	157/7206	5.52773233417e-06
ko04971	Gastric acid secretion	34/1177	98/7206	6.83138426597e-06
ko04966	Collecting duct acid secretion	14/1177	26/7206	1.23258207164e-05
ko04072	Phospholipase D signaling pathway	56/1177	197/7206	1.39089053007e-05
ko04514	Cell adhesion molecules (CAMs)	41/1177	130/7206	1.87268399946e-05
ko04745	Phototransduction - fly	17/1177	38/7206	3.46321007875e-05
ko04730	Long-term depression	27/1177	78/7206	7.26424111269e-05
ko05164	Influenza A	10/1177	167/7206	7.42014572751e-05
ko04360	Axon guidance	61/1177	233/7206	9.56037851443e-05
ko04110	Cell cycle	8/1177	145/7206	9.81031293854e-05
ko04010	MAPK signaling pathway	79/1177	321/7206	0.000101932600147
ko04141	Protein processing in endoplasmic reticulum	12/1177	184/7206	0.000103069687294
ko05169	Epstein-Barr virus infection	15/1177	206/7206	0.000166603233172
ko03008	Ribosome biogenesis in eukaryotes	2/1177	79/7206	0.000171659902552
ko04120	Ubiquitin mediated proteolysis	8/1177	138/7206	0.000266923247157
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1177	79/7206	0.000302413377234
ko05161	Hepatitis B	12/1177	173/7206	0.000349668512299
ko05140	Leishmaniasis	2/1177	75/7206	0.000395931088136
ko04064	NF-kappa B signaling pathway	4/1177	96/7206	0.00040627303734
ko05110	Vibrio cholerae infection	22/1177	63/7206	0.00040996559551
ko05414	Dilated cardiomyopathy	33/1177	112/7206	0.000427511951676
ko04924	Renin secretion	27/1177	86/7206	0.00056262923801
ko05205	Proteoglycans in cancer	25/1177	271/7206	0.000767840884157
ko04260	Cardiac muscle contraction	29/1177	98/7206	0.000848949119679
ko04626	Plant-pathogen interaction	9/1177	18/7206	0.000956805670149
ko04923	Regulation of lipolysis in adipocytes	24/1177	77/7206	0.00100308907976
ko04972	Pancreatic secretion	32/1177	111/7206	0.00102523399584
ko04610	Complement and coagulation cascades	3/1177	79/7206	0.00105585209928
ko04915	Estrogen signaling pathway	36/1177	131/7206	0.00113445874653
ko04750	Inflammatory mediator regulation of TRP channels	34/1177	122/7206	0.0011665805541
ko00520	Amino sugar and nucleotide sugar metabolism	1/1177	55/7206	0.0013609955456
ko04540	Gap junction	35/1177	128/7206	0.00151832269996
ko04612	Antigen processing and presentation	3/1177	77/7206	0.00156899208048
ko05162	Measles	8/1177	120/7206	0.00253809613747
ko04330	Notch signaling pathway	2/1177	62/7206	0.00273372878949
ko05166	HTLV-I infection	30/1177	292/7206	0.00350453051171
ko04014	Ras signaling pathway	64/1177	279/7206	0.00369590150389
ko04630	Jak-STAT signaling pathway	10/1177	132/7206	0.00412745496744
ko03420	Nucleotide excision repair	1/1177	46/7206	0.00441791477948
ko04976	Bile secretion	23/1177	80/7206	0.00544496450997
ko00480	Glutathione metabolism	2/1177	55/7206	0.0056995074721
ko05321	Inflammatory bowel disease (IBD)	2/1177	56/7206	0.00571529298806
ko03022	Basal transcription factors	1/1177	44/7206	0.00668894044395
ko04350	TGF-beta signaling pathway	7/1177	103/7206	0.00669354917669
ko05144	Malaria	1/1177	45/7206	0.0069846573587
ko00071	Fatty acid degradation	1/1177	45/7206	0.0069846573587
ko00240	Pyrimidine metabolism	8/1177	110/7206	0.00867748356579
ko00562	Inositol phosphate metabolism	24/1177	89/7206	0.00918444143174
ko04622	RIG-I-like receptor signaling pathway	3/1177	62/7206	0.00923454903633
ko04214	Apoptosis - fly	4/1177	72/7206	0.00964489161724
ko04710	Circadian rhythm	14/1177	43/7206	0.0108368291359
ko04658	Th1 and Th2 cell differentiation	7/1177	96/7206	0.0121417357921
ko00590	Arachidonic acid metabolism	2/1177	52/7206	0.0126202596703
ko04657	IL-17 signaling pathway	6/1177	87/7206	0.0128114994415
ko05133	Pertussis	6/1177	87/7206	0.0128114994415
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1177	59/7206	0.0131829495761
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1177	100/7206	0.0133767107119
ko05016	Huntington's disease	22/1177	215/7206	0.0144638951206
ko04930	Type II diabetes mellitus	16/1177	54/7206	0.0145191445536
ko03410	Base excision repair	1/1177	38/7206	0.0148791725044
ko05202	Transcriptional misregulation in cancer	19/1177	188/7206	0.0164466832198
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1177	14/7206	0.0172429643812
ko03018	RNA degradation	6/1177	84/7206	0.0174592299189
ko05145	Toxoplasmosis	11/1177	126/7206	0.0201018728243
ko04510	Focal adhesion	26/1177	240/7206	0.0205042248085
ko04922	Glucagon signaling pathway	31/1177	128/7206	0.0211055182465
ko05131	Shigellosis	6/1177	82/7206	0.0236341544485
ko05231	Choline metabolism in cancer	32/1177	134/7206	0.0241683332377
ko00310	Lysine degradation	5/1177	73/7206	0.0251164518431
ko04115	p53 signaling pathway	5/1177	74/7206	0.0254622053222
ko00280	Valine, leucine and isoleucine degradation	3/1177	54/7206	0.0264623290671
ko04146	Peroxisome	7/1177	89/7206	0.0294733180324
ko04371	Apelin signaling pathway	40/1177	177/7206	0.029935797417
ko04210	Apoptosis	19/1177	180/7206	0.0319536331576
ko04912	GnRH signaling pathway	29/1177	122/7206	0.034649599652
ko05206	MicroRNAs in cancer	19/1177	177/7206	0.0395910506611
ko04217	Necroptosis	19/1177	178/7206	0.0396231169613
ko04152	AMPK signaling pathway	36/1177	161/7206	0.0404838828822
ko04964	Proximal tubule bicarbonate reclamation	9/1177	29/7206	0.0421358941022
ko03320	PPAR signaling pathway	5/1177	69/7206	0.0474704356584
ko00230	Purine metabolism	42/1177	194/7206	0.0485348778572
ko05340	Primary immunodeficiency	1/1177	30/7206	0.049342851322