ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 50/502 145/7206 7.67420805762e-23 ko04110 Cell cycle 50/502 145/7206 7.67420805762e-23 ko04111 Cell cycle - yeast 35/502 90/7206 3.1804782213e-18 ko03030 DNA replication 23/502 38/7206 8.74049302173e-18 ko04080 Neuroactive ligand-receptor interaction 1/502 423/7206 1.66821838625e-12 ko03008 Ribosome biogenesis in eukaryotes 25/502 79/7206 4.76782056523e-11 ko04113 Meiosis - yeast 22/502 70/7206 8.21576437444e-10 ko03013 RNA transport 35/502 166/7206 1.93635351522e-09 ko05217 Basal cell carcinoma 21/502 68/7206 2.87032996863e-09 ko03430 Mismatch repair 11/502 22/7206 5.87385987785e-08 ko04144 Endocytosis 3/502 342/7206 8.24884743179e-08 ko03410 Base excision repair 14/502 38/7206 1.07947727197e-07 ko04020 Calcium signaling pathway 1/502 265/7206 1.12579922849e-07 ko04550 Signaling pathways regulating pluripotency of stem cells 30/502 165/7206 8.80882823601e-07 ko03015 mRNA surveillance pathway 21/502 93/7206 1.08913982002e-06 ko03440 Homologous recombination 13/502 41/7206 2.24667447731e-06 ko05202 Transcriptional misregulation in cancer 32/502 188/7206 2.78622520246e-06 ko04330 Notch signaling pathway 16/502 62/7206 3.29690722888e-06 ko00240 Pyrimidine metabolism 22/502 110/7206 5.21963923468e-06 ko04310 Wnt signaling pathway 30/502 181/7206 8.1708790268e-06 ko05010 Alzheimer's disease 1/502 202/7206 1.45779829129e-05 ko05224 Breast cancer 28/502 174/7206 2.59420411295e-05 ko05166 HTLV-I infection 40/502 292/7206 2.96958906424e-05 ko05322 Systemic lupus erythematosus 25/502 151/7206 5.49279013944e-05 ko04723 Retrograde endocannabinoid signaling 1/502 175/7206 6.55873620559e-05 ko04062 Chemokine signaling pathway 2/502 201/7206 0.000106369058166 ko03420 Nucleotide excision repair 11/502 46/7206 0.000239073400428 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/502 182/7206 0.000320660579893 ko04921 Oxytocin signaling pathway 3/502 209/7206 0.000439564657318 ko03018 RNA degradation 15/502 84/7206 0.000599416479075 ko04390 Hippo signaling pathway 26/502 188/7206 0.000680088084853 ko04072 Phospholipase D signaling pathway 3/502 197/7206 0.000884048559897 ko04022 cGMP-PKG signaling pathway 4/502 216/7206 0.000978317036628 ko04060 Cytokine-cytokine receptor interaction 3/502 191/7206 0.00125039085415 ko04725 Cholinergic synapse 2/502 160/7206 0.00140010190913 ko05206 MicroRNAs in cancer 24/502 177/7206 0.00143986341408 ko04218 Cellular senescence 24/502 177/7206 0.00143986341408 ko04270 Vascular smooth muscle contraction 2/502 154/7206 0.00200758863453 ko04621 NOD-like receptor signaling pathway 2/502 157/7206 0.00210468313491 ko03460 Fanconi anemia pathway 10/502 51/7206 0.00234064434888 ko04919 Thyroid hormone signaling pathway 20/502 143/7206 0.0023962466433 ko05168 Herpes simplex infection 24/502 182/7206 0.00266976268839 ko04912 GnRH signaling pathway 1/502 122/7206 0.00326636991102 ko04024 cAMP signaling pathway 8/502 279/7206 0.00373710478899 ko05414 Dilated cardiomyopathy 1/502 112/7206 0.00453171917501 ko04911 Insulin secretion 1/502 117/7206 0.00485807601593 ko04713 Circadian entrainment 2/502 136/7206 0.00585394448566 ko05034 Alcoholism 28/502 238/7206 0.00601043837228 ko04071 Sphingolipid signaling pathway 3/502 162/7206 0.006978865422 ko05203 Viral carcinogenesis 31/502 277/7206 0.00773928345712 ko04514 Cell adhesion molecules (CAMs) 2/502 130/7206 0.00832828807634 ko04915 Estrogen signaling pathway 2/502 131/7206 0.00838876384456 ko04142 Lysosome 3/502 151/7206 0.00928535153384 ko04670 Leukocyte transendothelial migration 3/502 151/7206 0.00928535153384 ko05160 Hepatitis C 3/502 153/7206 0.00935730806081 ko05410 Hypertrophic cardiomyopathy (HCM) 1/502 100/7206 0.0096298296854 ko05222 Small cell lung cancer 13/502 89/7206 0.00981005657484 ko05200 Pathways in cancer 49/502 492/7206 0.0099114789715 ko04925 Aldosterone synthesis and secretion 1/502 105/7206 0.0101606505836 ko01200 Carbon metabolism 2/502 128/7206 0.0124418055733 ko04650 Natural killer cell mediated cytotoxicity 1/502 97/7206 0.0141828819404 ko05132 Salmonella infection 1/502 98/7206 0.0143913411116 ko00564 Glycerophospholipid metabolism 1/502 99/7206 0.0146755972669 ko04350 TGF-beta signaling pathway 14/502 103/7206 0.0165882588443 ko04261 Adrenergic signaling in cardiomyocytes 6/502 205/7206 0.0172931905253 ko04141 Protein processing in endoplasmic reticulum 5/502 184/7206 0.0180329443149 ko04611 Platelet activation 4/502 163/7206 0.0184190856881 ko04810 Regulation of actin cytoskeleton 9/502 264/7206 0.0185536329126 ko04070 Phosphatidylinositol signaling system 2/502 112/7206 0.0236194769908 ko04371 Apelin signaling pathway 5/502 177/7206 0.0241864267589 ko04380 Osteoclast differentiation 3/502 134/7206 0.0249034391141 ko04114 Oocyte meiosis 17/502 139/7206 0.0263638858513 ko04924 Renin secretion 1/502 86/7206 0.0300160540795 ko04918 Thyroid hormone synthesis 1/502 86/7206 0.0300160540795 ko05133 Pertussis 1/502 87/7206 0.0305122217618 ko04662 B cell receptor signaling pathway 1/502 88/7206 0.0311523696894 ko00310 Lysine degradation 10/502 73/7206 0.0340011812882 ko04540 Gap junction 3/502 128/7206 0.0343336413682 ko04115 p53 signaling pathway 10/502 74/7206 0.0361806664726 ko04728 Dopaminergic synapse 6/502 185/7206 0.040251368682 ko05152 Tuberculosis 6/502 187/7206 0.0404120558288 ko04923 Regulation of lipolysis in adipocytes 1/502 77/7206 0.0424706101623 ko00230 Purine metabolism 21/502 194/7206 0.0435492849665 ko04137 Mitophagy - animal 1/502 82/7206 0.0447506143678 ko05100 Bacterial invasion of epithelial cells 2/502 99/7206 0.0465533323015 ko05146 Amoebiasis 2/502 99/7206 0.0465533323015 ko04620 Toll-like receptor signaling pathway 2/502 100/7206 0.0466153028652 ko05169 Epstein-Barr virus infection 22/502 206/7206 0.0499221640122