ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1154	423/7206	4.91185805883e-46
ko04724	Glutamatergic synapse	88/1154	152/7206	1.05734135901e-32
ko05033	Nicotine addiction	46/1154	56/7206	8.19218769507e-28
ko04727	GABAergic synapse	66/1154	110/7206	5.37068763459e-26
ko05032	Morphine addiction	64/1154	110/7206	3.42066526111e-24
ko04721	Synaptic vesicle cycle	53/1154	80/7206	4.57203254183e-24
ko04713	Circadian entrainment	72/1154	136/7206	1.12326542234e-23
ko04725	Cholinergic synapse	76/1154	160/7206	3.73785136175e-21
ko04728	Dopaminergic synapse	82/1154	185/7206	2.45310914687e-20
ko04723	Retrograde endocannabinoid signaling	74/1154	175/7206	4.7654088628e-17
ko04024	cAMP signaling pathway	100/1154	279/7206	1.34154730143e-16
ko04742	Taste transduction	37/1154	61/7206	2.5875633258e-15
ko04726	Serotonergic synapse	60/1154	137/7206	6.94607165846e-15
ko04020	Calcium signaling pathway	92/1154	265/7206	3.3176998839e-14
ko04921	Oxytocin signaling pathway	77/1154	209/7206	9.53955726714e-14
ko04911	Insulin secretion	52/1154	117/7206	2.23027460275e-13
ko04744	Phototransduction	25/1154	36/7206	1.03162870016e-12
ko04720	Long-term potentiation	43/1154	99/7206	6.92453847753e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1154	205/7206	9.61311018974e-11
ko05031	Amphetamine addiction	40/1154	91/7206	2.06578473959e-10
ko03040	Spliceosome	1/1154	145/7206	3.22854689165e-10
ko04970	Salivary secretion	39/1154	95/7206	3.89253392718e-09
ko05168	Herpes simplex infection	7/1154	182/7206	3.13036641122e-07
ko04971	Gastric acid secretion	36/1154	98/7206	4.6974041087e-07
ko05203	Viral carcinogenesis	17/1154	277/7206	6.16724842214e-07
ko04740	Olfactory transduction	31/1154	80/7206	7.15652633867e-07
ko04925	Aldosterone synthesis and secretion	37/1154	105/7206	1.20153869459e-06
ko04966	Collecting duct acid secretion	15/1154	26/7206	1.43494070719e-06
ko04360	Axon guidance	66/1154	233/7206	1.66990603061e-06
ko03013	RNA transport	7/1154	166/7206	2.80263127794e-06
ko05322	Systemic lupus erythematosus	6/1154	151/7206	4.94020105144e-06
ko04060	Cytokine-cytokine receptor interaction	10/1154	191/7206	5.32457216267e-06
ko04120	Ubiquitin mediated proteolysis	5/1154	138/7206	5.86060581423e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1154	74/7206	6.54977266633e-06
ko04010	MAPK signaling pathway	82/1154	321/7206	7.63313512752e-06
ko04022	cGMP-PKG signaling pathway	60/1154	216/7206	7.7906154174e-06
ko05164	Influenza A	8/1154	167/7206	9.1261334674e-06
ko05030	Cocaine addiction	27/1154	73/7206	1.30822366267e-05
ko04514	Cell adhesion molecules (CAMs)	40/1154	130/7206	2.80831905878e-05
ko04972	Pancreatic secretion	35/1154	111/7206	3.80525266985e-05
ko04014	Ras signaling pathway	71/1154	279/7206	3.89047555098e-05
ko04924	Renin secretion	29/1154	86/7206	4.27069602345e-05
ko04070	Phosphatidylinositol signaling system	35/1154	112/7206	4.46958490859e-05
ko04730	Long-term depression	27/1154	78/7206	5.94113653282e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1154	79/7206	6.86802960599e-05
ko04976	Bile secretion	27/1154	80/7206	8.14290611541e-05
ko04745	Phototransduction - fly	16/1154	38/7206	0.000112159845618
ko04110	Cell cycle	8/1154	145/7206	0.00014101478787
ko04141	Protein processing in endoplasmic reticulum	12/1154	184/7206	0.000141541141138
ko04072	Phospholipase D signaling pathway	52/1154	197/7206	0.000158428777657
ko04540	Gap junction	37/1154	128/7206	0.000212319613044
ko05169	Epstein-Barr virus infection	15/1154	206/7206	0.000224796437785
ko04964	Proximal tubule bicarbonate reclamation	13/1154	29/7206	0.0002322444216
ko04260	Cardiac muscle contraction	30/1154	98/7206	0.000250774391153
ko04610	Complement and coagulation cascades	2/1154	79/7206	0.000272799571917
ko03008	Ribosome biogenesis in eukaryotes	2/1154	79/7206	0.000272799571917
ko05414	Dilated cardiomyopathy	33/1154	112/7206	0.000358981273941
ko04621	NOD-like receptor signaling pathway	10/1154	157/7206	0.000376481993671
ko05140	Leishmaniasis	2/1154	75/7206	0.000385707215323
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1154	59/7206	0.000579489862856
ko04064	NF-kappa B signaling pathway	4/1154	96/7206	0.000614255566673
ko04915	Estrogen signaling pathway	36/1154	131/7206	0.000691495359813
ko05110	Vibrio cholerae infection	21/1154	63/7206	0.00072799407778
ko04626	Plant-pathogen interaction	9/1154	18/7206	0.00082478982126
ko05162	Measles	7/1154	120/7206	0.000996096399406
ko05161	Hepatitis B	13/1154	173/7206	0.00108244556887
ko05205	Proteoglycans in cancer	25/1154	271/7206	0.00127470645787
ko00480	Glutathione metabolism	1/1154	55/7206	0.00132707548917
ko04612	Antigen processing and presentation	3/1154	77/7206	0.00152887975328
ko04750	Inflammatory mediator regulation of TRP channels	33/1154	122/7206	0.00167431236042
ko00590	Arachidonic acid metabolism	1/1154	52/7206	0.00198712983755
ko04923	Regulation of lipolysis in adipocytes	23/1154	77/7206	0.00247307572816
ko04330	Notch signaling pathway	2/1154	62/7206	0.00269399693431
ko04214	Apoptosis - fly	3/1154	72/7206	0.0031950185038
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1154	14/7206	0.00321989198343
ko05166	HTLV-I infection	29/1154	292/7206	0.00323250933967
ko04371	Apelin signaling pathway	43/1154	177/7206	0.00356517106758
ko04146	Peroxisome	5/1154	89/7206	0.0051434313122
ko03022	Basal transcription factors	1/1154	44/7206	0.00672994931161
ko00071	Fatty acid degradation	1/1154	45/7206	0.00681348137329
ko03420	Nucleotide excision repair	1/1154	46/7206	0.00713782057816
ko04922	Glucagon signaling pathway	32/1154	128/7206	0.00732411452246
ko00240	Pyrimidine metabolism	8/1154	110/7206	0.00857756839214
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1154	100/7206	0.0088542364806
ko05206	MicroRNAs in cancer	16/1154	177/7206	0.00914338852259
ko00310	Lysine degradation	4/1154	73/7206	0.00974516434635
ko04115	p53 signaling pathway	4/1154	74/7206	0.00987055790468
ko04912	GnRH signaling pathway	30/1154	122/7206	0.0124751083431
ko00330	Arginine and proline metabolism	3/1154	61/7206	0.0133346419763
ko04930	Type II diabetes mellitus	16/1154	54/7206	0.0135137121452
ko04622	RIG-I-like receptor signaling pathway	3/1154	62/7206	0.0135588503133
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1154	92/7206	0.0139422997482
ko04973	Carbohydrate digestion and absorption	13/1154	42/7206	0.0173627275314
ko05133	Pertussis	6/1154	87/7206	0.0177316735122
ko00562	Inositol phosphate metabolism	23/1154	89/7206	0.0186887202256
ko04062	Chemokine signaling pathway	45/1154	201/7206	0.0187018279405
ko05217	Basal cell carcinoma	4/1154	68/7206	0.019072729333
ko04015	Rap1 signaling pathway	59/1154	278/7206	0.0192871976319
ko00630	Glyoxylate and dicarboxylate metabolism	1/1154	38/7206	0.0234036858776
ko03410	Base excision repair	1/1154	38/7206	0.0234036858776
ko04210	Apoptosis	18/1154	180/7206	0.0234856367822
ko03018	RNA degradation	6/1154	84/7206	0.0239370257991
ko04510	Focal adhesion	26/1154	240/7206	0.0250230210184
ko05145	Toxoplasmosis	11/1154	126/7206	0.0264359946565
ko05321	Inflammatory bowel disease (IBD)	3/1154	56/7206	0.0268235350687
ko04630	Jak-STAT signaling pathway	12/1154	132/7206	0.0302150364576
ko05231	Choline metabolism in cancer	31/1154	134/7206	0.0314153728153
ko00860	Porphyrin and chlorophyll metabolism	1/1154	34/7206	0.0334394612432
ko04658	Th1 and Th2 cell differentiation	8/1154	96/7206	0.0357164021325
ko00512	Mucin type O-glycan biosynthesis	9/1154	29/7206	0.0388549586976
ko04657	IL-17 signaling pathway	7/1154	87/7206	0.0393629740327
ko04350	TGF-beta signaling pathway	9/1154	103/7206	0.0420075632602
ko05202	Transcriptional misregulation in cancer	20/1154	188/7206	0.0434170822215
ko04668	TNF signaling pathway	11/1154	120/7206	0.0435201156124
ko04114	Oocyte meiosis	31/1154	139/7206	0.0468110069008