ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 54/465 191/7206 1.3882738495e-21 ko04380 Osteoclast differentiation 39/465 134/7206 2.59923230843e-16 ko04621 NOD-like receptor signaling pathway 40/465 157/7206 1.58660715012e-14 ko05164 Influenza A 41/465 167/7206 2.8949277471e-14 ko05162 Measles 32/465 120/7206 1.96229891819e-12 ko05140 Leishmaniasis 25/465 75/7206 2.38790361903e-12 ko05340 Primary immunodeficiency 16/465 30/7206 4.41169134691e-12 ko04650 Natural killer cell mediated cytotoxicity 28/465 97/7206 6.06548534159e-12 ko05321 Inflammatory bowel disease (IBD) 21/465 56/7206 1.05621912689e-11 ko05168 Herpes simplex infection 38/465 182/7206 5.39873242558e-11 ko04620 Toll-like receptor signaling pathway 27/465 100/7206 8.08371644646e-11 ko04630 Jak-STAT signaling pathway 31/465 132/7206 1.54195235259e-10 ko04064 NF-kappa B signaling pathway 26/465 96/7206 1.69498525058e-10 ko05330 Allograft rejection 13/465 24/7206 3.70167501223e-10 ko05320 Autoimmune thyroid disease 14/465 29/7206 5.66853406577e-10 ko04660 T cell receptor signaling pathway 29/465 124/7206 6.82310168988e-10 ko04658 Th1 and Th2 cell differentiation 25/465 96/7206 9.5167773715e-10 ko04659 Th17 cell differentiation 26/465 106/7206 1.78483066854e-09 ko05152 Tuberculosis 36/465 187/7206 1.89390373872e-09 ko04672 Intestinal immune network for IgA production 15/465 37/7206 2.80686239454e-09 ko05145 Toxoplasmosis 28/465 126/7206 4.65521895871e-09 ko04668 TNF signaling pathway 27/465 120/7206 6.63362766165e-09 ko04217 Necroptosis 34/465 178/7206 6.70785634977e-09 ko05150 Staphylococcus aureus infection 14/465 36/7206 1.82145255369e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/465 191/7206 1.4225686173e-07 ko05161 Hepatitis B 31/465 173/7206 1.47196407994e-07 ko04612 Antigen processing and presentation 19/465 77/7206 2.57600990908e-07 ko05310 Asthma 9/465 17/7206 2.74363131569e-07 ko05133 Pertussis 20/465 87/7206 4.3193340058e-07 ko05332 Graft-versus-host disease 9/465 18/7206 5.17562546406e-07 ko04622 RIG-I-like receptor signaling pathway 16/465 62/7206 1.20151339977e-06 ko04610 Complement and coagulation cascades 18/465 79/7206 1.88206108739e-06 ko04640 Hematopoietic cell lineage 16/465 64/7206 1.90375195328e-06 ko05323 Rheumatoid arthritis 19/465 89/7206 2.78010601452e-06 ko05144 Malaria 13/465 45/7206 3.08137876975e-06 ko04662 B cell receptor signaling pathway 18/465 88/7206 9.60268949645e-06 ko04940 Type I diabetes mellitus 10/465 32/7206 2.01620410976e-05 ko05142 Chagas disease (American trypanosomiasis) 22/465 130/7206 2.49938586559e-05 ko04210 Apoptosis 27/465 180/7206 3.50830144891e-05 ko04623 Cytosolic DNA-sensing pathway 11/465 41/7206 3.85626921879e-05 ko05160 Hepatitis C 23/465 153/7206 0.00014482824779 ko00120 Primary bile acid biosynthesis 7/465 20/7206 0.000165047286507 ko04062 Chemokine signaling pathway 27/465 201/7206 0.000224346518671 ko04657 IL-17 signaling pathway 15/465 87/7206 0.000393207263364 ko04390 Hippo signaling pathway 2/465 188/7206 0.000719576271623 ko03040 Spliceosome 1/465 145/7206 0.00101117760623 ko04310 Wnt signaling pathway 2/465 181/7206 0.00102090419618 ko04664 Fc epsilon RI signaling pathway 13/465 77/7206 0.00116050200026 ko04145 Phagosome 21/465 162/7206 0.00184301647364 ko04137 Mitophagy - animal 13/465 82/7206 0.00209831713462 ko05134 Legionellosis 12/465 74/7206 0.00253196589521 ko05034 Alcoholism 5/465 238/7206 0.00286256524239 ko04728 Dopaminergic synapse 3/465 185/7206 0.00347578040812 ko04724 Glutamatergic synapse 2/465 152/7206 0.00415904775774 ko05418 Fluid shear stress and atherosclerosis 21/465 173/7206 0.00437456761446 ko00051 Fructose and mannose metabolism 8/465 42/7206 0.00476487381337 ko04611 Platelet activation 20/465 163/7206 0.00527318501059 ko05132 Salmonella infection 14/465 98/7206 0.00527434852539 ko00590 Arachidonic acid metabolism 9/465 52/7206 0.00548344913562 ko04080 Neuroactive ligand-receptor interaction 14/465 423/7206 0.00556282768799 ko04514 Cell adhesion molecules (CAMs) 17/465 130/7206 0.00559051086591 ko00592 alpha-Linolenic acid metabolism 5/465 19/7206 0.00597600248967 ko05166 HTLV-I infection 31/465 292/7206 0.00690853385774 ko04933 AGE-RAGE signaling pathway in diabetic complications 17/465 135/7206 0.00705063462682 ko04916 Melanogenesis 2/465 142/7206 0.008568897331 ko04972 Pancreatic secretion 1/465 111/7206 0.00992322855196 ko04670 Leukocyte transendothelial migration 18/465 151/7206 0.0107934023482 ko04713 Circadian entrainment 2/465 136/7206 0.0121995758784 ko04726 Serotonergic synapse 2/465 137/7206 0.0123666610355 ko04917 Prolactin signaling pathway 12/465 87/7206 0.0124950592813 ko04666 Fc gamma R-mediated phagocytosis 15/465 122/7206 0.0141632008419 ko01200 Carbon metabolism 2/465 128/7206 0.0170078092555 ko05012 Parkinson's disease 3/465 155/7206 0.0188555168523 ko05131 Shigellosis 11/465 82/7206 0.019733344786 ko03050 Proteasome 8/465 54/7206 0.0213936363551 ko05202 Transcriptional misregulation in cancer 20/465 188/7206 0.0235590110871 ko05416 Viral myocarditis 8/465 55/7206 0.0236757122639 ko04360 Axon guidance 7/465 233/7206 0.0288914203543 ko04114 Oocyte meiosis 3/465 139/7206 0.0348201566903 ko05146 Amoebiasis 12/465 99/7206 0.0351836702959 ko04068 FoxO signaling pathway 18/465 167/7206 0.0358882937142 ko04020 Calcium signaling pathway 9/465 265/7206 0.0403936063904 ko05010 Alzheimer's disease 6/465 202/7206 0.0407688067868 ko05169 Epstein-Barr virus infection 21/465 206/7206 0.0419659536992 ko01230 Biosynthesis of amino acids 1/465 85/7206 0.0431817371931 ko04727 GABAergic synapse 2/465 110/7206 0.047661284063 ko05032 Morphine addiction 2/465 110/7206 0.047661284063