ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 20/279 80/7206 1.26986385073e-11 ko04724 Glutamatergic synapse 25/279 152/7206 5.82027574988e-10 ko04728 Dopaminergic synapse 27/279 185/7206 1.82753276496e-09 ko04911 Insulin secretion 19/279 117/7206 9.05462000563e-08 ko04725 Cholinergic synapse 22/279 160/7206 1.84805929191e-07 ko04713 Circadian entrainment 20/279 136/7206 2.23673402316e-07 ko04024 cAMP signaling pathway 30/279 279/7206 2.93250717701e-07 ko04966 Collecting duct acid secretion 9/279 26/7206 3.00909579491e-07 ko05120 Epithelial cell signaling in Helicobacter pylori infection 16/279 92/7206 3.68224219408e-07 ko05110 Vibrio cholerae infection 13/279 63/7206 6.11867220979e-07 ko04727 GABAergic synapse 17/279 110/7206 9.08113306217e-07 ko04261 Adrenergic signaling in cardiomyocytes 24/279 205/7206 1.05368216003e-06 ko05031 Amphetamine addiction 15/279 91/7206 1.74893485701e-06 ko04360 Axon guidance 25/279 233/7206 3.1559480182e-06 ko04726 Serotonergic synapse 18/279 137/7206 4.84105852698e-06 ko04720 Long-term potentiation 15/279 99/7206 5.19408673628e-06 ko00190 Oxidative phosphorylation 17/279 127/7206 6.91854758183e-06 ko04723 Retrograde endocannabinoid signaling 20/279 175/7206 1.24037193965e-05 ko05032 Morphine addiction 15/279 110/7206 1.93193499184e-05 ko04114 Oocyte meiosis 17/279 139/7206 2.33383504914e-05 ko04626 Plant-pathogen interaction 6/279 18/7206 3.99867360348e-05 ko04921 Oxytocin signaling pathway 21/279 209/7206 5.34701469507e-05 ko04750 Inflammatory mediator regulation of TRP channels 15/279 122/7206 6.65798585199e-05 ko04070 Phosphatidylinositol signaling system 14/279 112/7206 9.71672022936e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/279 191/7206 0.000139217075967 ko04371 Apelin signaling pathway 18/279 177/7206 0.000157754056048 ko05010 Alzheimer's disease 19/279 202/7206 0.000289134453749 ko04010 MAPK signaling pathway 26/279 321/7206 0.000300722299146 ko05152 Tuberculosis 18/279 187/7206 0.000314205845281 ko04971 Gastric acid secretion 12/279 98/7206 0.000370645932488 ko04722 Neurotrophin signaling pathway 16/279 160/7206 0.000441012715596 ko04145 Phagosome 16/279 162/7206 0.000506779240799 ko04745 Phototransduction - fly 7/279 38/7206 0.000543606179484 ko05323 Rheumatoid arthritis 11/279 89/7206 0.000597712527291 ko04370 VEGF signaling pathway 10/279 77/7206 0.000711277524423 ko04912 GnRH signaling pathway 13/279 122/7206 0.00082974368035 ko05214 Glioma 10/279 79/7206 0.000872652431125 ko04740 Olfactory transduction 10/279 80/7206 0.000963960875263 ko04973 Carbohydrate digestion and absorption 7/279 42/7206 0.00101801285702 ko05033 Nicotine addiction 8/279 56/7206 0.00128770419998 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/279 59/7206 0.00181854051263 ko04022 cGMP-PKG signaling pathway 18/279 216/7206 0.00189149003048 ko05014 Amyotrophic lateral sclerosis (ALS) 9/279 74/7206 0.00208580669464 ko04062 Chemokine signaling pathway 17/279 201/7206 0.00227684169037 ko04925 Aldosterone synthesis and secretion 11/279 105/7206 0.0023598580261 ko04014 Ras signaling pathway 21/279 279/7206 0.00365310694989 ko04922 Glucagon signaling pathway 12/279 128/7206 0.00386437993062 ko04218 Cellular senescence 15/279 177/7206 0.00433096777324 ko04260 Cardiac muscle contraction 10/279 98/7206 0.00445353120068 ko04960 Aldosterone-regulated sodium reabsorption 6/279 41/7206 0.00458152131202 ko05100 Bacterial invasion of epithelial cells 10/279 99/7206 0.00478928594462 ko04071 Sphingolipid signaling pathway 14/279 162/7206 0.00549889866696 ko04060 Cytokine-cytokine receptor interaction 1/279 191/7206 0.00716647466399 ko04066 HIF-1 signaling pathway 11/279 123/7206 0.00791330389175 ko04142 Lysosome 13/279 151/7206 0.00798978132644 ko00680 Methane metabolism 5/279 34/7206 0.00929393169608 ko04970 Salivary secretion 9/279 95/7206 0.0109689273078 ko04650 Natural killer cell mediated cytotoxicity 9/279 97/7206 0.0124808358137 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/279 14/7206 0.0152185727726 ko04930 Type II diabetes mellitus 6/279 54/7206 0.0173378610977 ko04924 Renin secretion 8/279 86/7206 0.017784239542 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/279 15/7206 0.0184881436841 ko04662 B cell receptor signaling pathway 8/279 88/7206 0.0201728998444 ko03013 RNA transport 1/279 166/7206 0.0223409999439 ko00010 Glycolysis / Gluconeogenesis 7/279 74/7206 0.0238325121659 ko04072 Phospholipase D signaling pathway 14/279 197/7206 0.0238356881299 ko04964 Proximal tubule bicarbonate reclamation 4/279 29/7206 0.0243610596298 ko04664 Fc epsilon RI signaling pathway 7/279 77/7206 0.0289040620409 ko04742 Taste transduction 6/279 61/7206 0.0298309618415 ko04940 Type I diabetes mellitus 4/279 32/7206 0.0337150358069 ko04514 Cell adhesion molecules (CAMs) 10/279 130/7206 0.0345376336596 ko04020 Calcium signaling pathway 17/279 265/7206 0.0347137716238 ko00521 Streptomycin biosynthesis 2/279 8/7206 0.0358394910647 ko05230 Central carbon metabolism in cancer 7/279 81/7206 0.0367366359133 ko04015 Rap1 signaling pathway 18/279 278/7206 0.0368319670595 ko04012 ErbB signaling pathway 9/279 109/7206 0.0380608882313 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/279 1/7206 0.0387177352208 ko04380 Osteoclast differentiation 10/279 134/7206 0.039424846552 ko04972 Pancreatic secretion 9/279 111/7206 0.0397839719198 ko04933 AGE-RAGE signaling pathway in diabetic complications 10/279 135/7206 0.0407822434157 ko05212 Pancreatic cancer 7/279 83/7206 0.0411317058648 ko04910 Insulin signaling pathway 12/279 172/7206 0.0428727045605 ko05210 Colorectal cancer 7/279 86/7206 0.0483431739143