ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	150/823	423/7206	1.17699781943e-41
ko04724	Glutamatergic synapse	75/823	152/7206	7.49779961406e-32
ko05033	Nicotine addiction	44/823	56/7206	1.77260118263e-31
ko04727	GABAergic synapse	56/823	110/7206	7.23999175029e-25
ko05032	Morphine addiction	55/823	110/7206	6.10481112611e-24
ko04713	Circadian entrainment	56/823	136/7206	2.91604963179e-19
ko04728	Dopaminergic synapse	67/823	185/7206	3.14549285445e-19
ko04723	Retrograde endocannabinoid signaling	64/823	175/7206	1.15586025116e-18
ko04024	cAMP signaling pathway	78/823	279/7206	9.78383617117e-15
ko04721	Synaptic vesicle cycle	35/823	80/7206	1.95011329895e-13
ko04742	Taste transduction	30/823	61/7206	2.3397308529e-13
ko04725	Cholinergic synapse	51/823	160/7206	2.16726184048e-12
ko04911	Insulin secretion	40/823	117/7206	4.83845774377e-11
ko05030	Cocaine addiction	29/823	73/7206	3.97926564959e-10
ko04726	Serotonergic synapse	41/823	137/7206	2.78723612118e-09
ko04261	Adrenergic signaling in cardiomyocytes	53/823	205/7206	4.91071672447e-09
ko04740	Olfactory transduction	29/823	80/7206	4.95205862022e-09
ko05031	Amphetamine addiction	31/823	91/7206	8.26871825459e-09
ko04744	Phototransduction	18/823	36/7206	1.12050954882e-08
ko04020	Calcium signaling pathway	62/823	265/7206	1.80067808421e-08
ko04921	Oxytocin signaling pathway	52/823	209/7206	2.90879191089e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	26/823	74/7206	6.50616656179e-08
ko04720	Long-term potentiation	30/823	99/7206	2.82298288817e-07
ko04010	MAPK signaling pathway	67/823	321/7206	5.61099642732e-07
ko03040	Spliceosome	1/823	145/7206	8.88729660643e-07
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/823	79/7206	4.16174072928e-06
ko05203	Viral carcinogenesis	10/823	277/7206	4.36863169978e-06
ko04970	Salivary secretion	27/823	95/7206	4.38022102355e-06
ko04514	Cell adhesion molecules (CAMs)	33/823	130/7206	8.23396183975e-06
ko04925	Aldosterone synthesis and secretion	28/823	105/7206	1.38781006086e-05
ko04072	Phospholipase D signaling pathway	43/823	197/7206	2.02658620128e-05
ko05322	Systemic lupus erythematosus	4/823	151/7206	0.000136468797474
ko03013	RNA transport	5/823	166/7206	0.000164682739685
ko04060	Cytokine-cytokine receptor interaction	7/823	191/7206	0.000188489983407
ko05205	Proteoglycans in cancer	13/823	271/7206	0.000188751985817
ko04260	Cardiac muscle contraction	24/823	98/7206	0.000288158912993
ko04971	Gastric acid secretion	24/823	98/7206	0.000288158912993
ko04360	Axon guidance	45/823	233/7206	0.000328878721586
ko05168	Herpes simplex infection	7/823	182/7206	0.000361323682638
ko04972	Pancreatic secretion	26/823	111/7206	0.00039327867932
ko05414	Dilated cardiomyopathy	26/823	112/7206	0.000417192624462
ko04730	Long-term depression	20/823	78/7206	0.000423981101958
ko04022	cGMP-PKG signaling pathway	42/823	216/7206	0.000451972005137
ko04120	Ubiquitin mediated proteolysis	4/823	138/7206	0.000584019205154
ko03008	Ribosome biogenesis in eukaryotes	1/823	79/7206	0.0011584520718
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/823	182/7206	0.00129568513539
ko00240	Pyrimidine metabolism	3/823	110/7206	0.00138197431954
ko04540	Gap junction	27/823	128/7206	0.00170532397353
ko05164	Influenza A	7/823	167/7206	0.00183870062866
ko04915	Estrogen signaling pathway	27/823	131/7206	0.00201418954899
ko05162	Measles	4/823	120/7206	0.00220700674153
ko04150	mTOR signaling pathway	9/823	184/7206	0.00308447906022
ko04621	NOD-like receptor signaling pathway	7/823	157/7206	0.0032809826135
ko04110	Cell cycle	6/823	145/7206	0.00334746162118
ko04137	Mitophagy - animal	2/823	82/7206	0.00491134675787
ko03018	RNA degradation	2/823	84/7206	0.00497930876852
ko04140	Autophagy - animal	8/823	164/7206	0.00583382394346
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/823	59/7206	0.00634416277573
ko04930	Type II diabetes mellitus	13/823	54/7206	0.00794819706664
ko00330	Arginine and proline metabolism	1/823	61/7206	0.00820932166188
ko04640	Hematopoietic cell lineage	1/823	64/7206	0.00858540662376
ko05016	Huntington's disease	13/823	215/7206	0.00887258465357
ko05140	Leishmaniasis	2/823	75/7206	0.0101498880508
ko04612	Antigen processing and presentation	2/823	77/7206	0.0103500493429
ko05410	Hypertrophic cardiomyopathy (HCM)	20/823	100/7206	0.0106534672513
ko04214	Apoptosis - fly	2/823	72/7206	0.0145553994046
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/823	14/7206	0.015905031289
ko04923	Regulation of lipolysis in adipocytes	16/823	77/7206	0.0171826752627
ko00280	Valine, leucine and isoleucine degradation	1/823	54/7206	0.0177445095334
ko04141	Protein processing in endoplasmic reticulum	11/823	184/7206	0.0181201221048
ko05166	HTLV-I infection	21/823	292/7206	0.0186133474716
ko05169	Epstein-Barr virus infection	13/823	206/7206	0.0189299237553
ko04976	Bile secretion	16/823	80/7206	0.0210351972205
ko04138	Autophagy - yeast	3/823	81/7206	0.0220106355425
ko04064	NF-kappa B signaling pathway	4/823	96/7206	0.0223474022718
ko05034	Alcoholism	38/823	238/7206	0.02930260504
ko04510	Focal adhesion	17/823	240/7206	0.0299362909151
ko00190	Oxidative phosphorylation	7/823	127/7206	0.0338119884722
ko01200	Carbon metabolism	7/823	128/7206	0.0341038916028
ko04745	Phototransduction - fly	9/823	38/7206	0.0342188553284
ko04142	Lysosome	9/823	151/7206	0.0372005217821
ko00270	Cysteine and methionine metabolism	1/823	47/7206	0.0380784174933
ko05204	Chemical carcinogenesis	1/823	48/7206	0.0382543631124
ko00260	Glycine, serine and threonine metabolism	1/823	48/7206	0.0382543631124
ko05161	Hepatitis B	11/823	173/7206	0.0385095838287
ko05231	Choline metabolism in cancer	23/823	134/7206	0.0397307949507
ko04350	TGF-beta signaling pathway	5/823	103/7206	0.0403925773562
ko04924	Renin secretion	16/823	86/7206	0.0408222396775
ko04657	IL-17 signaling pathway	4/823	87/7206	0.0413326264965
ko05133	Pertussis	4/823	87/7206	0.0413326264965
ko04146	Peroxisome	4/823	89/7206	0.0420424144663
ko01212	Fatty acid metabolism	2/823	60/7206	0.04204272984
ko04330	Notch signaling pathway	2/823	62/7206	0.042452470022
ko04014	Ras signaling pathway	43/823	279/7206	0.0430385436141
ko04068	FoxO signaling pathway	11/823	167/7206	0.0482150373281