ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1111	423/7206	1.38734084584e-46
ko04724	Glutamatergic synapse	81/1111	152/7206	6.03966436636e-28
ko05033	Nicotine addiction	45/1111	56/7206	3.54179848969e-27
ko05032	Morphine addiction	65/1111	110/7206	4.70937259892e-26
ko04721	Synaptic vesicle cycle	51/1111	80/7206	7.90606639846e-23
ko04727	GABAergic synapse	59/1111	110/7206	8.18232459073e-21
ko04713	Circadian entrainment	67/1111	136/7206	8.66957833227e-21
ko04728	Dopaminergic synapse	78/1111	185/7206	7.89921712965e-19
ko04725	Cholinergic synapse	70/1111	160/7206	4.65288025762e-18
ko04723	Retrograde endocannabinoid signaling	72/1111	175/7206	9.19436505905e-17
ko04742	Taste transduction	36/1111	61/7206	6.16747455328e-15
ko04024	cAMP signaling pathway	94/1111	279/7206	8.7145157175e-15
ko04911	Insulin secretion	51/1111	117/7206	2.09817166563e-13
ko04020	Calcium signaling pathway	88/1111	265/7206	2.21528313171e-13
ko04726	Serotonergic synapse	55/1111	137/7206	1.45228465354e-12
ko04921	Oxytocin signaling pathway	72/1111	209/7206	4.20818551337e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1111	205/7206	3.83877968117e-10
ko04744	Phototransduction	21/1111	36/7206	4.0455980502e-09
ko05031	Amphetamine addiction	37/1111	91/7206	4.6283528643e-09
ko04970	Salivary secretion	38/1111	95/7206	4.94511216203e-09
ko04740	Olfactory transduction	34/1111	80/7206	5.02389737497e-09
ko04720	Long-term potentiation	39/1111	99/7206	5.20204246689e-09
ko03040	Spliceosome	2/1111	145/7206	1.6474854245e-08
ko05168	Herpes simplex infection	5/1111	182/7206	3.04623520201e-08
ko05322	Systemic lupus erythematosus	4/1111	151/7206	5.06175149844e-07
ko04022	cGMP-PKG signaling pathway	61/1111	216/7206	1.16186176612e-06
ko04060	Cytokine-cytokine receptor interaction	8/1111	191/7206	1.18881872094e-06
ko05203	Viral carcinogenesis	17/1111	277/7206	2.36577009865e-06
ko04925	Aldosterone synthesis and secretion	35/1111	105/7206	3.83972133882e-06
ko04966	Collecting duct acid secretion	14/1111	26/7206	6.16187812677e-06
ko05164	Influenza A	7/1111	167/7206	6.1624848389e-06
ko04971	Gastric acid secretion	33/1111	98/7206	6.33235114594e-06
ko04360	Axon guidance	62/1111	233/7206	7.5798544088e-06
ko04730	Long-term depression	28/1111	78/7206	8.52594463122e-06
ko04514	Cell adhesion molecules (CAMs)	40/1111	130/7206	1.12934531737e-05
ko04120	Ubiquitin mediated proteolysis	5/1111	138/7206	1.31289606682e-05
ko05030	Cocaine addiction	26/1111	73/7206	2.09734995701e-05
ko04621	NOD-like receptor signaling pathway	7/1111	157/7206	2.6087989912e-05
ko03013	RNA transport	8/1111	166/7206	2.75828357335e-05
ko04540	Gap junction	38/1111	128/7206	3.41005023656e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1111	74/7206	6.94580204304e-05
ko04745	Phototransduction - fly	16/1111	38/7206	7.01758949779e-05
ko04110	Cell cycle	7/1111	145/7206	0.000100908428668
ko05110	Vibrio cholerae infection	22/1111	63/7206	0.000126741827224
ko04010	MAPK signaling pathway	75/1111	321/7206	0.000134258537781
ko04064	NF-kappa B signaling pathway	3/1111	96/7206	0.000168047238903
ko04924	Renin secretion	27/1111	86/7206	0.000213480402034
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1111	79/7206	0.000241015381571
ko04260	Cardiac muscle contraction	29/1111	98/7206	0.000333859474428
ko03008	Ribosome biogenesis in eukaryotes	2/1111	79/7206	0.000415539509175
ko04371	Apelin signaling pathway	45/1111	177/7206	0.000453656081501
ko05162	Measles	6/1111	120/7206	0.000516394715848
ko05169	Epstein-Barr virus infection	15/1111	206/7206	0.000556120413178
ko05140	Leishmaniasis	2/1111	75/7206	0.000594365651049
ko04964	Proximal tubule bicarbonate reclamation	12/1111	29/7206	0.000686293367747
ko04014	Ras signaling pathway	64/1111	279/7206	0.000688637008041
ko04972	Pancreatic secretion	31/1111	111/7206	0.000761924958012
ko04141	Protein processing in endoplasmic reticulum	13/1111	184/7206	0.00084802729545
ko04214	Apoptosis - fly	2/1111	72/7206	0.000876724410516
ko05205	Proteoglycans in cancer	24/1111	271/7206	0.00146777880116
ko04915	Estrogen signaling pathway	34/1111	131/7206	0.00201333564451
ko05414	Dilated cardiomyopathy	30/1111	112/7206	0.0021019298986
ko04610	Complement and coagulation cascades	3/1111	79/7206	0.0024116921852
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1111	59/7206	0.00310606406928
ko04626	Plant-pathogen interaction	8/1111	18/7206	0.00320723139899
ko01524	Platinum drug resistance	3/1111	76/7206	0.0034209298585
ko04072	Phospholipase D signaling pathway	46/1111	197/7206	0.00348869677899
ko04070	Phosphatidylinositol signaling system	29/1111	112/7206	0.0034902783983
ko04923	Regulation of lipolysis in adipocytes	22/1111	77/7206	0.00361200272756
ko05166	HTLV-I infection	28/1111	292/7206	0.00370864078533
ko04922	Glucagon signaling pathway	32/1111	128/7206	0.00422251554213
ko00240	Pyrimidine metabolism	7/1111	110/7206	0.00506025697998
ko05161	Hepatitis B	14/1111	173/7206	0.00535211312699
ko03420	Nucleotide excision repair	1/1111	46/7206	0.00691550639626
ko04146	Peroxisome	5/1111	89/7206	0.00725860670009
ko04750	Inflammatory mediator regulation of TRP channels	30/1111	122/7206	0.00748134211259
ko05321	Inflammatory bowel disease (IBD)	2/1111	56/7206	0.00864196182078
ko04630	Jak-STAT signaling pathway	10/1111	132/7206	0.0101255497971
ko04612	Antigen processing and presentation	4/1111	77/7206	0.0101530877176
ko04657	IL-17 signaling pathway	5/1111	87/7206	0.0101967876872
ko03022	Basal transcription factors	1/1111	44/7206	0.0104440020072
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1111	100/7206	0.011459049887
ko04976	Bile secretion	21/1111	80/7206	0.0117384609078
ko04210	Apoptosis	16/1111	180/7206	0.0118977868615
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1111	182/7206	0.0121004510755
ko00480	Glutathione metabolism	2/1111	55/7206	0.0130494673114
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1111	14/7206	0.0130795616338
ko04916	Melanogenesis	33/1111	142/7206	0.0131878112897
ko00310	Lysine degradation	4/1111	73/7206	0.0139561293656
ko04668	TNF signaling pathway	9/1111	120/7206	0.014665899823
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1111	40/7206	0.0154358308271
ko00140	Steroid hormone biosynthesis	1/1111	41/7206	0.0154645288376
ko05145	Toxoplasmosis	10/1111	126/7206	0.017440902936
ko05222	Small cell lung cancer	6/1111	89/7206	0.0180290856636
ko05131	Shigellosis	5/1111	82/7206	0.0195995552352
ko04330	Notch signaling pathway	3/1111	62/7206	0.0198512640033
ko04622	RIG-I-like receptor signaling pathway	3/1111	62/7206	0.0198512640033
ko04658	Th1 and Th2 cell differentiation	7/1111	96/7206	0.0226374422191
ko03410	Base excision repair	1/1111	38/7206	0.022927181126
ko05133	Pertussis	6/1111	87/7206	0.0243645081192
ko00562	Inositol phosphate metabolism	22/1111	89/7206	0.0252254611502
ko04217	Necroptosis	17/1111	178/7206	0.0269972627058
ko05217	Basal cell carcinoma	4/1111	68/7206	0.027044640393
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1111	92/7206	0.0288209162384
ko05215	Prostate cancer	9/1111	111/7206	0.0330343709107
ko04115	p53 signaling pathway	5/1111	74/7206	0.0351554633929
ko00982	Drug metabolism - cytochrome P450	1/1111	37/7206	0.0358111520524
ko04620	Toll-like receptor signaling pathway	8/1111	100/7206	0.0362993346828
ko00071	Fatty acid degradation	2/1111	45/7206	0.0376742315716
ko04930	Type II diabetes mellitus	14/1111	54/7206	0.0378201496205
ko05202	Transcriptional misregulation in cancer	19/1111	188/7206	0.0405110397842
ko04962	Vasopressin-regulated water reabsorption	15/1111	58/7206	0.0417816030371
ko04270	Vascular smooth muscle contraction	33/1111	154/7206	0.0420410275515
ko05212	Pancreatic cancer	6/1111	83/7206	0.0449516919397